Gnotobiotics /

Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals. In response to the development of new tools for microbiota and microbiome analysis, the increasing recognit...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Schoeb, Trenton R. (Editor ), Eaton, Kathryn A. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, an imprint of Elsevier, [2017]
Colección:American College of Laboratory Animal Medicine series.
Temas:
Germfree life.
Germ-Free Life
Animals
Gnotobiologie.
TECHNOLOGY & ENGINEERING > Agriculture > Animal Husbandry.
Germfree life
Internet Resources.
Acceso en línea:Texto completo

MARC

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245 0 0 |a Gnotobiotics /  |c edited by Trenton R. Schoeb, Kathryn A. Eaton. 
264 1 |a London :  |b Academic Press, an imprint of Elsevier,  |c [2017] 
264 4 |c �2017 
300 |a 1 online resource (xiii, 414 pages) :  |b illustrations (chiefly color 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a American College of Laboratory Animal Medicine series 
504 |a Includes bibliographical references and index. 
588 0 |a Print version record. 
505 0 |6 880-01  |a Front Cover; Gnotobiotics; Dedication; Gnotobiotics; Copyright; Contents; List of Contributors; Foreword; 1 -- Historical Overview; REFERENCES; 2 -- PRINCIPLES OF ESTABLISHING AND OPERATING A GNOTOBIOTIC FACILITY*; 1. INTRODUCTION; 2. INSTITUTIONAL FACTORS; 2.1 Financial Support; 2.2 Space Requirements; 2.3 Autoclave; 2.4 Personnel; 2.5 Microbiology Laboratory; 2.6 Facility Productivity and Experimental Utilization; 2.7 Facility Operation and Compliance; 3. ISOLATOR SELECTION; 3.1 Isolator Types and Construction; Chamber; Air Supply; Transfer Port; Gloves 
505 8 |a 3.2 Individual Positive Pressure Cage Systems4. STERILIZATION; 4.1 Steam; 4.2 Ionizing Radiation; 4.3 Liquid Chemical; Peracetic (Peroxyacetic, Ethaneperoxoic) Acid; Chlorine Dioxide; Other Liquid Products; Application of Liquid Sterilants; Monitoring Liquid Sterilization; 4.4 Gas and Vapor Chemical; 4.5 Dry Heat; 4.6 Filtration; 4.7 Further Information; 5. OPERATION; 5.1 Standard Operating Procedures; 5.2 Isolator Setup; Cleaning and Inspection; Leak Testing; Sterilization; 5.3 Sterilization and Entry of Supplies; Sterilizing Cylinders and Packs; Food; Water; Other Materials and Supplies 
505 8 |a Port Sterilization5.4 Introduction and Transfer of Animals; 5.5 Working in Isolators; 5.6 Monitoring for Contamination; Sources of Contamination; Inspection and Observation; Microbiological Monitoring; Sampling; Fecal Wet Mounts and Gram Staining; Culture; Molecular Methods; Serologic Testing; Frequency of Monitoring; Summary; 5.7 Derivation of Germfree Mice; Hysterotomy and Hysterectomy; Embryo Transfer; 5.8 Establishing Defined Microbiota; Altered Schaedler Flora; Other Microbiota; 6. RESOURCES; 6.1 Recommended Reading; Gnotobiotics; Sterilization; 6.2 Online; 6.3 Manufacturers 
505 8 |a 6.4 LaboratoriesGLOSSARY; REFERENCES; 3 -- PROCEDURES FOR RODENTS*; 1. INTRODUCTION; 2. BACKGROUND AND ACKNOWLEDGMENTS; 2.1 University of Texas Southwestern Medical Center (UT Southwestern); 2.2 University of Michigan (Michigan); 2.3 University of Alabama at Birmingham (UAB); 2.4 Baylor College of Medicine (BCM); 3. GENERAL INFORMATION; 3.1 UT Southwestern; Equipment; Access; Compliance; 3.2 UAB; Equipment; Staff; General Work Practices; Access; Compliance; 3.3 BCM; Equipment; Staff; Access; Compliance; 4. STERILIZATION AND STERILIZATION MONITORING; 4.1 UT Southwestern; Autoclaving 
505 8 |a Quality AssuranceCycles; Liquid Sterilization; 4.2 UAB; Autoclaving; General; Quality Assurance; Cycles; Liquid Sterilization; General; Sterilants; Quality Assurance; Sprayer (Atomizer); Air Hose Connection; Maintenance; 4.3 BCM; Autoclaving; Liquid Sterilization; 5. STERILIZING CYLINDERS; 5.1 UT Southwestern; Filter Medium Installation and Replacement; Equipment and Supplies; Procedure; Cylinder Maintenance; Supply Cylinders; Equipment and Supplies; Procedure; Packing Drawstring Bags; Equipment and Supplies; Procedure for Food; Procedure for Bedding 
520 8 |a Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals. In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource. Reviews and defines gnotobiotic animal speciesAnalyzes microbiota in numerous contextsPresents detailed coverage of the protocols and operation of a gnotobiotic facility. 
650 0 |a Germfree life. 
650 1 2 |a Germ-Free Life  |0 (DNLM)D005856 
650 0 2 |a Animals  |0 (DNLM)D000818 
650 6 |a Gnotobiologie.  |0 (CaQQLa)201-0026635 
650 7 |a TECHNOLOGY & ENGINEERING  |x Agriculture  |x Animal Husbandry.  |2 bisacsh 
650 7 |a Germfree life  |2 fast  |0 (OCoLC)fst00942161 
655 4 |a Internet Resources. 
700 1 |a Schoeb, Trenton R.,  |e editor  |4 edt 
700 1 |a Eaton, Kathryn A.,  |e editor  |4 edt 
776 0 8 |i Print version:  |t Gnotobiotics.  |d London : Academic Press, an imprint of Elsevier, [2017]  |z 9780128045619  |z 0128045612  |w (OCoLC)974698900 
830 0 |a American College of Laboratory Animal Medicine series. 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780128045619  |z Texto completo 
880 0 |6 505-00/(S  |a Contents note continued: 8.7. Algae -- 9. Other Considerations for Gnotobiotic Fish Husbandry -- 10. Derivation of Germfree Stickleback Embryos -- 10.1. Solutions -- References -- 7. Use of Gnotobiotic Mice in the Study of Metabolic Syndrome / Andrew T. Gewirtz -- 1. Introduction -- 1.1. To What Extent Is a Microbiota Required for Metabolic Syndrome-- 1.2. Is an Altered Microbiota Sufficient to Drive Metabolic Syndrome-- 2. Conclusion and Future Directions -- Acknowledgments -- References -- 8. Gnotobiotics and Inflammatory Bowel Disease / Trenton R. Schoeb -- 1. Introduction -- 2. Cytokines and Cytokine Signaling -- 2.1. Interleukin-10 -- 2.2. Interleukin-2 -- 2.3. TGF-β1 -- 2.4. TNF-α -- 2.5. Other Cytokines -- 3.T-Cell Receptors and MHC -- 3.1.T-Cell Receptor and MHC II Deficient Mice -- 3.2. HLA B27 β2m Transgenic Rats -- 4. Other Mutants -- 4.1. Core 1-Derived O-Glycan Deficiency -- 4.2. Fas-Associated via Death Domain Protein -- 4.3. Glutathione Peroxidase Deficiency 
880 0 |6 505-01/(S  |a Contents note continued: 4.4. Nfil3 Deficiency -- 4.5. PI3 Kinase p110δ Deficiency -- 4.6. Telomerase Deficiency -- 4.7.T-Bet Deficiency -- 4.8. TLR5 Deficiency -- 5.T-Cell Transfer -- 6. Inbred Strains -- 6.1. SAMP1/Yit -- 6.2.C3H/HeJBir -- 7. Conclusion. 

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