Dynein mechanics : structure, biology and disease. Volume 2, Dynein mechanics, dysfunction, and disease /

Dyneins: Structure, Biology and Disease, Second Edition, offers a broad view of dyneins mechanics, dysfunction, and disease, providing an overview of dyneins from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein str...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: King, Stephen M. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London ; San Diego, CA : Academic Press, [2018]
Edición:Second edition.
Temas:
Dynein.
Microtubules.
Microtubules
Dyn�eine.
SCIENCE > Life Sciences > Anatomy & Physiology.
Dynein
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Machine generated contents note: Volume 2
  • pt. I Structure and Mechanics of Dynein Motors
  • 1. Electron microscopy of isolated dynein complexes and the power stroke mechanism / Ken'ya Furuta
  • 1.1. Introduction
  • 1.2. Historical background of dyneins
  • 1.3. Electron microscopic techniques used in recent dynein research
  • 1.4. Properties of dynein molecules revealed by advanced electron microscopic techniques
  • 1.5. Force generating mechanism of dynein
  • References
  • 2. Mechanism and regulation of dynein motors / Andrew P. Carter
  • 2.1. Overall architecture of the dynein motor
  • 2.2. mechanochemical cycle of the dynein motor
  • 2.3. Conformational changes in the AAA+ ring drive the mechanochemical cycle
  • 2.4. remodeling of the linker during the mechanochemical cycle
  • 2.5. ATP hydrolysis primes the dynein motor for microtubule rebinding and the linker power stroke
  • 2.6. Variations of the dynein mechanochemical cycle
  • 2.7. How dynein motors walk along the microtubule
  • 2.8. Determinants of dynein directionality
  • 2.9. Dynein motor activation by cargo binding
  • 2.10. Conclusions
  • References
  • 3. Structural analysis of dynein intermediate and light chains / Amrita Dawn
  • 3.1. Introduction
  • 3.2. Abbreviated background of light chains
  • 3.3. Structure of the apo light chains
  • 3.4. Structure of liganded light chains
  • 3.5. LC8 and TcTex-1 promiscuity
  • 3.6. Light chain isoforms
  • 3.7. Mammalian dynein intermediate chains
  • 3.8. Molecular model of the light-intermediate chain structure
  • 3.9. Light chains and cargo
  • 3.10. Posttranslational modifications
  • 3.11. role of LC8 and TcTex-1 on dynein
  • 3.12. Summary
  • References
  • 4. Biochemical purification of axonemal and cytoplasmic dyneins / Kazuo Inaba
  • 4.1. Introduction
  • 4.2. Axonemal dyneins
  • 4.3. Cytoplasmic dynein
  • 4.4. Storage of dynein
  • 4.5. Conclusion and perspective
  • Acknowledgments
  • References
  • 5. Single-molecule dynein motor mechanics in vitro / Ahmet Yildiz
  • 5.1. Introduction
  • 5.2. mechanochemical cycle of dynein
  • 5.3. Processivity of a dynein dimer
  • 5.4. Velocity of dynein motors
  • 5.5. stepping mechanism
  • 5.6. Stepping pattern of the two motor domains
  • 5.7. role of the AAA sites in dynein motility
  • 5.8. Force generation
  • 5.9. mechanism of minus end directionality
  • 5.10. Mammalian dynein/dynactin complex
  • 5.11. Future directions
  • Acknowledgments
  • References
  • 6. Biophysical properties of dynein in vivo / Steven P. Gross
  • 6.1. Motility and regulation of dynein in vitro
  • 6.2. Biophysical function of dynein in vivo
  • 6.3. Regulation of dynein motility in vivo
  • References
  • 7. Mechanics of bidirectional cargo transport / William O. Hancock
  • 7.1. Introduction
  • 7.2. Experimental and computational work to date on bidirectional transport
  • 7.3. Models of bidirectional transport
  • 7.4. Kinesins involved in bidirectional transport
  • 7.5. Dynein properties relevant to bidirectional transport
  • 7.6. Roles of MAPs and tubulin PTMs in bidirectional transport
  • 7.7. Potential effects of membrane fluidity on bidirectional transport
  • 7.8. Concluding thoughts
  • References
  • 8. Chemical probes for dynein / Tarun M. Kapoor
  • 8.1. General approach to inhibiting dynein
  • 8.2. Nucleotide-mimetic inhibitors of dynein
  • 8.3. Ciliobrevins: cell-permeable small molecule dynein inhibitors
  • 8.4. Other approaches that allow fast temporal control over dynein function
  • Acknowledgments
  • References
  • 9. Computational modeling of dynein activity and the generation of flagellar beating waveforms / Jonathan Howard
  • 9.1. Introduction
  • 9.2. Models for beat control in the flagellum
  • 9.3. Theory
  • 9.4. Discussion
  • A.1. Coefficient equations for the boundary value problem
  • A.2. Parameter normalizations
  • References
  • pt. II Dynein Dysfunction and Disease
  • 10. Impacts of virus-mediated manipulation of host Dynein / Andrew J. Mouland
  • 10.1. Dynein and viral replication
  • 10.2. Kinesins
  • 10.3. Innate immunity, the Rabs, Rab7-interacting lysosomal protein, and vesicular transport
  • 10.4. Dynein, viruses, and the innate immune response
  • 10.5. IFITM3 and VAP-A
  • 10.6. Dyneins and nuclear integration of viral DNA
  • 10.7. Posttranslationally modified microtubules and Dynein
  • 10.8. Emerging viruses and co-opting of Dynein
  • Major outstanding questions
  • Acknowledgments
  • References
  • 11. use of mouse models to probe cytoplasmic dynein function / Mike Fainzilber
  • 11.1. rationale behind using a genetic approach to study the dynein complex
  • 11.2. Different approaches for mouse genetic studies
  • 11.3. allelic series of mutations in the cytoplasmic dynein heavy chain gene, Dync1h1
  • 11.4. DYNC1H1 mutations in humans
  • 11.5. Dynein light chain and intermediate chain mutants
  • 11.6. Dynactin mutant mice
  • 11.7. Conclusions
  • Acknowledgments
  • References
  • 12. Cytoplasmic dynein and its regulators in neocortical development and disease / Richard B. Vallee
  • 12.1. Neocortical development
  • 12.2. role of dynein in radial glia progenitors and interkinetic nuclear migration
  • 12.3. Roles for the dynein pathway in postmitotic neuronal precursors
  • 12.4. Overview of malformations of cortical development associated with dynein mutations
  • 12.5. Lissencephaly associated with LIS1 mutations
  • 12.6. Malformations of cortical development associated with DYNC1H1 mutations
  • 12.7. NDE1 mutations and the pathogenesis of severe microcephaly
  • 12.8. Summary
  • Acknowledgments
  • References
  • 13. Cytoplasmic dynein dysfunction and neurodegenerative disease / Erika L.F. Holzbaur
  • 13.1. Introduction
  • 13.2. Cytoplasmic dynein function in neurons
  • 13.3. Dynein dysfunction in mice
  • 13.4. Mutations in dynein and in dynein effectors result in a spectrum of neurodevelopmental and neurodegenerative disease in humans
  • 13.5. Dynein dysfunction in the pathogenesis of neurodegenerative disease: ALS, HD, and PD
  • 13.6. Conclusions
  • References
  • 14. Dynein dysfunction as a cause of primary ciliary dyskinesia and other ciliopathies / Heymut Omran
  • 14.1. Introduction
  • 14.2. Ultrastructure of motile cilia
  • 14.3. Outer dynein arms
  • 14.4. Inner dynein arms
  • 14.5. Ciliopathies
  • 14.6. Nodal cilia
  • 14.7. Ependymal cilia and hydrocephalus
  • 14.8. Sperm flagella and male infertility
  • 14.9. Fallopian tubes and female infertility
  • 14.10. Primary cilia dyskinesia
  • 14.11. Molecular defects affecting outer dynein arm components and docking
  • 14.12. Molecular defects affecting cytoplasmic preassembly of dynein arms
  • 14.13. Preassembly defects of ODA complex type-2 and DNALI1-associated IDA complexes
  • 14.14. Preassembly defects of ODA type-1 and type-2 and DNALI1-associated IDA complexes
  • 14.15. Molecular defects affecting the 96-nm axonemal ruler
  • 14.16. Molecular defects affecting the nexin-dynein regulatory complex
  • 14.17. Molecular defects affecting ciliary beat regulation
  • References
  • 15. Severe skeletal abnormalities caused by defects in retrograde intraflagellar transport dyneins / Hannah M.
  • Mitchison
  • 15.1. Introduction
  • 15.2. Role of cilia in skeletal development
  • 15.3. Clinical features of skeletal ciliopathies
  • 15.4. Cell biological basis of skeletal ciliopathies due to IFT defects
  • 15.5. Genetic basis of dynein-based skeletal ciliopathies associated with IFT defects
  • 15.6. Human mutations in cytoplasmic IFT dynein-2 genes
  • 15.7. Future perspective on clinical spectrum, new clinical models, and therapy
  • Acknowledgments
  • References
  • 16. Ciliary dynein dysfunction caused by chronic alcohol exposure / Maureen Wirschell
  • 16.1. Overview
  • 16.2. Alcohol and mucociliary function
  • 16.3. Alcohol and Chlamydomonas flagella
  • 16.4. New questions and future directions
  • References
  • 17. Dynein-based motility of pathogenic protozoa / Kent L. Hill
  • 17.1. Introduction: impact of flagellated protozoan parasites on human health and agriculture
  • 17.2. Biology and mechanism of flagellar motility in parasite infections
  • 17.3. Final remarks
  • Supplementary data
  • Acknowledgments
  • References
  • 18. Dynein axonemal light chain 4: involvement in congenital mirror movement disorder / John B. Vincent
  • 18.1. Introduction
  • 18.2. Axonemal dynein components: biology and disease
  • 18.3. Conclusions
  • References
  • 19. Does dynein influence the non-Mendelian inheritance of chromosome 17 homologues in male mice? / Stephen H. Pilder
  • 19.1. Prevailing models of the genetic and functional basis of phenotypes specific to male mice carrying t-haplotypes during the early years of the genomics era
  • 19.2. Properties of t-complex testis expressed-1
  • 19.3. Properties of t-complex testis expressed-2
  • 19.4. Properties of Dnahc8
  • 19.5. Chromosomal deletion analysis modifies Lyon's model
  • 19.6. Identification of t-complex distorters
  • 19.7. What about dyneins?
  • References.

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