Nanomedicine in Central Nervous System Injury and Repair /

Nanomedicine in Central Nervous System Injury and Repair (IRN), Volume 137, the latest release in the International Review of Neurobiology series presents comprehensive chapters that cover a broad range of topics, including, but not limited to, how Diabetes exacerbates methamphetamine induced blood-...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Sharma, H. S. (Hari Shanker) (Editor ), Sharma, Aruna (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2017.
Colección:International review of neurobiology ; v. 137.
Temas:
Nanomedicine.
Central nervous system > Wounds and injuries.
Nanotechnology.
Nanomedicine
Central Nervous System > injuries
Nanotechnology
Nanom�edecine.
Nanotechnologie.
HEALTH & FITNESS > Holism.
HEALTH & FITNESS > Reference.
MEDICAL > Alternative Medicine.
MEDICAL > Atlases.
MEDICAL > Essays.
MEDICAL > Family & General Practice.
MEDICAL > Holistic Medicine.
MEDICAL > Osteopathy.
Central nervous system > Wounds and injuries
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Nanomedicine in Central Nervous System Injury and Repair
  • Copyright
  • Contents
  • Contributors
  • Preface
  • References
  • Acknowledgments
  • Chapter One: Current Strategies for the Delivery of Therapeutic Proteins and Enzymes to Treat Brain Disorders
  • 1. Introduction
  • 2. Physical Delivery
  • 3. Nonphysical Methods
  • 3.1. Systemic Delivery
  • 3.2. In Vitro Targeting
  • 3.3. In Vivo Proteins, Fusion Proteins, and Modified Enzymes
  • 3.4. Nanoparticle-Based Delivery
  • 4. Conclusion
  • References
  • Chapter Two: Impact of Inflammation on the Blood-Neural Barrier and Blood-Nerve Interface: From Review to Therapeutic Preview1. Introduction
  • 2. Blood-Nerve Interface
  • 3. Mast Cells and the BBB
  • 4. Immune Cell Interactions Amplify Neuroinflammation
  • 5. Neuroinflammation and Aging
  • 6. Mast Cells and Glia as Therapeutic Targets
  • 7. Conclusion and Perspectives
  • Acknowledgments
  • Conflict of Interest
  • References
  • Chapter Three: Intravenous Administration of Functionalized Magnetic Iron Oxide Nanoparticles Does Not Induce CNS Injury ...
  • 1. Introduction1.1. Magnetic Iron Oxide Nanoparticles
  • 1.2. Polymer-Coated Iron Oxide Nanoparticles
  • 1.3. Superparamagnetic Iron Oxide Nanoparticles
  • 2. Experimental Procedures
  • 3. SCI Model
  • 4. Nanoparticle Administration
  • 5. Treatment With Cerebrolysin
  • 5.1. Blood-Spinal Cord Barrier/BBB Permeability
  • 5.2. Edema Formation
  • 5.3. Morphological Changes in the Cord
  • 5.4. Experimental Observations
  • 5.4.1. Iron Oxide Nanoparticles Effect on BSCB/BBB Permeability
  • 5.4.2. Morphological Changes Inside the Cord
  • 6. Effects of Cerebrolysin on BBB/BSCB Permeability6.1. Effects of Cerebrolysin on Neuronal and Glial Cell Damage
  • 6.2. Probable Mechanisms of IOMNP-Induced Neurotoxicity
  • 6.3. Cerebrolysin-Induced Neuroprotection
  • 7. Conclusion and Future Perspectives
  • Acknowledgments
  • References
  • Chapter Four: Histaminergic Receptors Modulate Spinal Cord Injury-Induced Neuronal Nitric Oxide Synthase Upregulation and ...
  • 1. Introduction
  • 2. Histamine in the Spinal Cord
  • 3. Histamine and Nitric Oxide Interaction
  • 4. Histamine and the Spinal Cord Microcirculation5. Histamine and the BSCB Permeability
  • 6. Histamine and Spinal Cord Edema
  • 7. Nanowired Drug Delivery Enhances Neuroprotection
  • 8. Our Investigations on Histamine-Receptor Modulation and nNOS Expression in SCI
  • 8.1. Animals
  • 8.2. Spinal Cord Injury
  • 8.3. Drug Treatments
  • 8.4. TiO2-Nanowired Delivery of Cimetidine and Ranitidine
  • 8.5. Parameters Measured
  • 8.6. BSCB Permeability
  • 8.7. Spinal Cord Edema
  • 8.8. Spinal Cord Blood Flow
  • 8.9. Morphological Analyses

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