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In vitro toxicology /
In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput s...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press, an imprint of Elsevier,
[2017]
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a In vitro toxicology / |c editor, Alok Dhawan, PhD, Director, CSIR-Indian Institute of Toxicology Research, Lucknow, India, Seok Kwon, PhD, Principal Scientist, Central Product Safety, Global Product Stewardship, Singapore Innovation Center, Procter & Gamble International Operations, Singapore. |
| 264 | 1 | |a London : |b Academic Press, an imprint of Elsevier, |c [2017] | |
| 264 | 4 | |c �2018 | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 588 | 0 | |a Online resource; title from PDF title page (EBSCO, viewed November 15, 2017). | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Front Cover -- In Vitro Toxicology -- In Vitro Toxicology -- Copyright -- Contents -- List of Contributors -- Editors Biographies -- Foreword -- Preface -- Acknowledgments -- 1 -- Development of In Vitro Toxicology: A Historic Story -- INTRODUCTION -- WHAT IN VITRO TOXICOLOGY AND HOW IT CAME INTO BEING? -- WHY IN VITRO NOT IN VIVO? -- THE REGULATORY CONTROL AND POLICY MAKERS -- PROJECTS AND DEVELOPMENTS -- SOME OF THE VALIDATED IN VITRO ALTERNATIVES AND METHODS -- THE AVAILABLE IN VITRO MODELS SYSTEMS -- Explant/Organ Culture -- Cell Culture | |
| 505 | 8 | |a Primary Cell CultureImmortalized Cell Lines -- Organotypic Cultures -- Stem Cells and Induced Pluripotent Stem Cells -- Organoid Culture -- BASAL TO ORGAN-SPECIFIC ENDPOINTS OF IN VITRO TOXICOLOGY -- Basal Toxicity or Cytotoxicity -- Tetrazolium Bromide Salt Assay -- Lactate Dehydrogenase Assay -- Neutral Red Uptake Assay -- Acetoxymethyl Diacetylester of Calcein Cytotoxicity Assay -- Adenosine Triphosphate Quantification and Adenosine Triphosphate/Adenosine Diphosphate Ratio Assay -- Genotoxicity -- CELLS TO 3D ORGANOIDS: IN VITRO ORGAN SYSTEM TOXICOLOGY | |
| 505 | 8 | |a Hepatoxicity In VitroNeurotoxicity In Vitro -- Nephrotoxicity In Vitro -- Cardiotoxicity In Vitro -- Nanotoxicology In Vitro -- SUMMARY -- SUGGESTED WEB PORTALS FOR FURTHER READING -- REFERENCES -- 2 -- Principles for In Vitro Toxicology -- INTRODUCTION -- GUIDELINES GOVERNING THE IN VITRO METHODS FOR TOXICITY TESTING -- OPTIMIZATION OF CELL CULTURE -- MODELS OF IN VITRO TOXICITY -- Explant Culture -- Organotypic Culture -- Cell Cultures -- Three Dimensional Culture Systems -- DEVELOPMENT OF BIOMARKERS FOR IN VITRO TOXICITY EVALUATION | |
| 505 | 8 | |a ASSAYS FOR SCREENING OF TOXICANTSAmes Test -- The Hen�a#x80;#x99;s Egg Test�a#x80;#x93;Chorio Allantoic Membrane Test -- Corrosivity Assays -- 3T3 Neutral Red Uptake Test -- Tetrazolium Salt, 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide Assay -- Alamar Blue -- The Bovine Cornea Opacity/Permeability Test -- DOSE�a#x80;#x93;RESPONSE RELATIONSHIP -- Evaluation of DR Relationship -- DATA INTERPRETATION -- VALIDATION OF IN VITRO TOXICOLOGY TEST METHODS -- THE �a#x80;#x9C;OMICS�a#x80;#x9D; APPROACH -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES | |
| 505 | 8 | |a 3 -- Models and Methods for In Vitro ToxicityINTRODUCTION -- NEED OF IN VITRO MODELS FOR TOXICITY ASSESSMENT -- VALIDATION OF IN VITRO TEST METHODS -- Criteria for Validation -- Criteria for Regulatory Acceptance -- MODELS FOR IN VITRO TOXICITY ASSESSMENT -- In Vitro Models for Cytotoxicity Studies -- In Vitro Models for Specific Toxicity -- In Vitro Models for Liver Toxicity -- In Vitro Models for Lung Toxicity -- In Vitro Models for Neurotoxicity -- In Vitro Models for Immunotoxicity -- METHODS EMPLOYED FOR IN VITRO TOXICITY ASSESSMENT | |
| 520 | |a In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing. Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials. | ||
| 650 | 0 | |a Toxicology. | |
| 650 | 2 | |a Toxicology |0 (DNLM)D014116 | |
| 650 | 6 | |a Toxicologie. |0 (CaQQLa)201-0054329 | |
| 650 | 7 | |a toxicology. |2 aat |0 (CStmoGRI)aat300251568 | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a Toxicology |2 fast |0 (OCoLC)fst01153364 | |
| 700 | 1 | |a Dhawan, Alok, |e editor. | |
| 700 | 1 | |a Kwon, Seok, |e editor. | |
| 776 | 0 | 8 | |i Print version: |z 0128046678 |z 9780128046678 |w (OCoLC)978515635 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128046678 |z Texto completo |
| 880 | 0 | 0 | |6 505-00/(S |t Naciff -- |t Introduction -- |t Why Do We Have to Assess the Potential Estrogenicity of Chemicals of Interest-- |t Transcriptional Profiling in In Vitro Systems to Determine the Potential Estrogenic Activity of Chemicals of Interest -- |t Connectivity Mapping to Define Mode of Action -- |t In vitro to in Vivo Extrapolation -- |t Conclusion -- |t References -- |g 7. |t Extrapolation of In Vitro Results to Predict Human Toxicity / |r Sonali Das -- |t Need to Understand Toxicity -- |t Organ Level and System Level Toxicity -- |t Hepatotoxicity -- |t Toxicity Assessment In Vitro: Advantages and Disadvantages -- |t In Vitro Systems for Liver Toxicity Assessment -- |t In Vitro System for Nephrotoxicity Assessment -- |t To Overcome In Vitro Assay Limitation -- |t Extrapolation of In Vitro Information to In Vivo for Human: Successful and Unsuccessful Outcomes -- |t Upcoming Potential Methods to Predict Toxicity -- |t References -- |g 8. |t Role of Molecular Chaperone Network in Understanding In Vitro Proteotoxicity / |r Smriti Priya -- |t Introduction -- |t Balance Between Protein Folding and Misfolding: Misfolded Proteins Are Toxic Species -- |t Mechanisms of Cellular Proteotoxicity -- |t Cellular Defense Against Proteotoxicity: Molecular Chaperones -- |t Role in Proteotoxicity: Molecular Chaperones Antagonizes the Accumulation of Proteotoxic Proteins -- |t Cellular Degradation Mechanism in Proteotoxicity -- |t Ubiquitin Proteasome System -- |t Autophagy -- |t Specific Role of Degradation Pathways in Mitigating Proteotoxicity -- |t Toxicity of Amyloid Beta in AD -- |t Toxicity of α-Synuclein in PD -- |t Toxicity of Huntingtin Protein in HD -- |t Prion Proteins in Encephalopathies -- |t Conclusion -- |t References -- |g 9. |t Scientific and Regulatory Considerations in the Development of in Vitro Techniques for Toxicology / |r Rajesh Sundar -- |t Introduction -- |t Why In Vitro Toxicity-- |t In Vitro Assays for Safety and Toxicity Assessment -- |t Cytotoxicity Assessment -- |t Assessment of Carcinogenicity -- |t Reproductive and Developmental Toxicity Assessment -- |t Phototoxicity Assessment -- |t Hepatotoxicity -- |t Safety Pharmacology -- |t Tissue Cross-Reactivity Assay -- |t Application of the Principles of GLP to in Vitro Studies -- |t Validation of in Vitro Methods -- |t Regulatory Acceptance of Alternative Methods to Animal Testing -- |t Translational Aspects of in Vitro Assays -- |t Pitfalls in In Vitro Toxicology -- |t Acknowledgments -- |t References -- |g 10. |t Safety Concerns Using Cell-Based In Vitro Methods for Toxicity Assessment / |r Vyas Shingatgeri -- |t Introduction -- |t Biosafety and Risk Management in In Vitro Laboratories -- |t Risk-Classification Based on Type of Cells -- |t Risk Associated With Cell Culture -- |t Who May Be at Risk-- |t Factors Contributing Toward Risk in the Cell Culture -- |t Tissue/Type, Origin, and Source of Cells -- |t Viral Contaminanation -- |t Problems Associated With Viral Contaminations -- |t Origin of Viral Contaminations -- |t Mycoplasmas -- |t How Does Mycoplasma Enter Cell Cultures-- |t Culture Media -- |t Transmission Involving Use of Needles and Sharp Objects During Manipulations -- |t Fetal Bovine Serum -- |t Handling Cells Outside Biosafety Cabinets -- |t Altering Culture Conditions -- |t Risk Associated With Procedures Involving Cryobanks/Liquid Nitrogen -- |t Risk Associated With Procedures Involving CO2 Cylinders -- |t Risk Associated With Procedures Involving Toxic Compounds -- |t Physical Hazards and Others -- |t Ergonomic Hazards -- |t Ionizing Radiations -- |t Nonionizing Radiations -- |t Noise Hazards -- |t Recommended Practices -- |t Containment Measures for Working With Cell Cultures -- |t State and Federal Regulations -- |t OSHA Standards -- |t Laboratory Standards -- |t Hazard Communication Standards -- |t Blood Borne Pathogens Standard -- |t Personal Protective Equipment Standard (29 CFR 1910.132) -- |t Eye and Face Protection Standard (29 CFR 1910.133) -- |t Respiratory Protection Standard (29 CFR 1910.134) -- |t Hand Protection Standard (29 CFR 1910.138) -- |t Control of Hazardous Energy Standard (29 CFR 1910.47) -- |t Conclusions -- |t References -- |t Further Reading -- |g 11. |t In Vitro Methods for Predicting Ocular Irritation / |r Seok Kwon -- |t Introduction -- |t In Vitro Methods Adopted by OECD -- |t Isolated Chicken Eye Test -- |t Bovine Corneal Opacity and Permeability Test -- |t Fluorescein Leakage Assay -- |t Short Time Exposure Test -- |t Reconstructed Human Cornea-Like Epithelium Test Method -- |t Recent Development and Looking Into Future -- |t Conclusion -- |t References. |