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Cell polarity in development and disease /
Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, UK :
Academic Press, an imprint of Elsevier,
[2018]
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| Colección: | Perspectives on translational cell biology series.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Machine generated contents note:
- 1. Cell Polarity in Oocyte Development / Douglas W. Houston
- Introduction
- Oogenesis and the Establishment of Animal
- Vegetal Polarity
- Origin of Animal
- Vegetal Polarity During Oogenesis
- Xenopus
- Zebrafish
- Mouse
- Polarity and the Ovarian Stem Cell
- Structural Basis for Mitochondrial Cloud/Balbiani Formation
- Macf1
- Buckyball
- Generation of Cortical Polarity in the Oocyte and Egg
- Cortical Polarity and Sperm Entry
- Apical
- Basal Polarization of the Xenopus Egg
- Cortical Polarity and Superficial Cell Fate
- Concluding Remarks
- Acknowledgments
- References
- 2. Pluripotency
- What Does Cell Polarity Have to Do With It / Amy Ralston
- Mammalian Pluripotency
- Cell Polarity in the Mammalian Embryo
- Emergence of Pluripotency in the Mouse Embryo
- Cell Polarity in the Mammalian Early Embryo
- How Cell Polarity Regulates Establishment of Pluripotency in the Mouse Embryo
- Cell Polarity and Embryo-Derived Pluripotent Stem Cell Lines
- Multiple States of Pluripotency
- Polarization of Pluripotent Stem Cell Lines
- Cell Polarization During Somatic Cell Reprogramming
- Conclusions
- Acknowledgments
- References
- 3. Cell Polarity and Asymmetric Cell Division by the Wnt Morphogen / Bryan T. Phillips
- Introduction
- Binary Cell Fate Specification via Asymmetric Cell Division
- PAR Proteins Polarize Caenorhabditis elegans Zygotes
- Delta/Notch Signaling Drives Asymmetric Cell Division in Fly Neuroblasts
- Morphogens as Cell Polarizers
- Wnt/�I²-Catenin Signal Transduction
- Wnt/�I²-Catenin Asymmetry and Asymmetric Cell Division in Caenorhabditis elegans
- Caenorhabditis elegans Epidermal Seam Stem Cell Lineage Undergoes Reiterative Asymmetric Cell Divisions
- Asymmetric Cell Divisions in the Caenorhabditis elegans Seam Require Wnt Signaling
- SYS-1/�I²-Catenin Inheritance Is Limited by Centrosomal Degradation
- Caenorhabditis elegans/Asymmetric Cell Division-Specific Phenomena
- PRY-1/Axin Is Upstream of the Destruction Complex
- KIN-19 Versus GSK-3 Function in �I²-Catenin Regulation
- Future of Wnt/�I²-Catenin and Asymmetric Cell Division
- APR-1 as the Key Regulator of Differential W�I²A Outputs
- Dishevelled Balances Wnt/�I²-Catenin Asymmetry Outputs
- Wnt Ligands and Receptors
- Concluding Remarks
- Acknowledgments
- References
- 4. Cell Polarity in Morphogenesis
- Planar Cell Polarity / Raymond Habas
- Introduction
- Planar Cell Polarity Pathway
- Wnts
- Asymmetric Protein Localization: From Flies to Vertebrates
- Role of Cytoskeletal Components During Gastrulation
- Actin
- Microtubules
- Planar Cell Polarity Regulation: Cross Talk Between Cytoskeletal Components
- Planar Cell Polarity in Vertebrates
- Conclusions
- References
- 5. Polarized Membrane Trafficking in Development and Disease: From Epithelia Polarization to Cancer Cell Invasion / Rytis Prekeris
- Introduction
- Epithelial Polarity and Lumen Formation
- Membrane Transport and Polarization of Individual Epithelial Cells
- Polarized Membrane Transport and Apical Lumen Formation During Epithelial Tissue Morphogenesis
- Regulation of De Novo Lumen Formation In Vivo
- Polarized Membrane Transport During Cancer Metastasis and Development
- Podosomes and Cell Migration
- Invadopodia and Cancer Cell Metastasis
- Membrane Transport and MMP Targeting During Invadopodia Formation
- Concluding Remarks
- Acknowledgments
- References
- 6. Planar Cell Polarity and the Cell Biology of Nervous System Development and Disease / J. Robert Manak
- Introduction
- Breaking the Rules
- Effectors of Planar Cell Polarity Genes
- Axonal Determination/Polarization: Connections to Polarity Genes
- Planar Cell Polarity Mutants Exhibit Axonal Extension Defects
- Axonal Extension and the Dynamics of the Cytoskeleton
- Lamellipodia and Filopodia Use Different Actin Nucleators
- Neuronal Cell Migration Uses the Same Players as During Axonal Polarization
- Adherens Junction: A Convergence of Interdependent Signaling Complexes
- Focal Adhesions: Reinventing the Adherens Junction for Cellular Movement and Migration
- Convergence Extension Defects Leading to Open Neural Tube
- Conclusions
- Acknowledgments
- References
- 7. Planar Cell Polarity in Ciliated Epithelia / Laurent Kodjabachian
- Introduction
- Initiation and Coordination of Tissue-Level Planar Polarity in Ciliated Epithelia
- Xenopus Embryonic Epidermis
- Mouse Trachea
- Mouse Ependyma
- Transmission of Planar Cell Polarity to Basal Bodies in Multiciliated Cells
- Xenopus Mucociliary Epidermis
- Mouse Trachea
- Mouse Ependyma
- Future Challenges
- General Conclusion
- Acknowledgments
- References.