Peptidomics of cancer-derived enzyme products /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Hu, Xiaohua, 1960- (Editor ), Tamanoi, Fuyuhiko (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2017.
Edición:First edition.
Colección:Enzymes ; v. 42.
Temas:
Peptides > Analysis.
Peptides > analysis
Peptides > Analyse.
SCIENCE > Life Sciences > Biology.
Peptides > Analysis
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Peptidomics of Cancer-Derived Enzyme Products
  • Copyright
  • Contents
  • Contributors
  • Preface
  • Overview
  • 1. Molecular Changes in Cancer
  • 2. Peptidomes and Advance in Mass Spectrometry
  • 3. Nanotechnology and Nanodevices
  • 4. Future Perspective
  • Chapter One: Circulating Peptidome and Tumor-Resident Proteolysis
  • 1. Introduction
  • 1.1. Intracellular Proteases
  • 1.1.1. Caspases (Cysteine Protease)
  • 1.1.2. Deubiquitinases (Cysteine and Zinc Proteases)
  • 1.1.3. Autophagins (Cysteine Proteases)
  • 1.2. Extracellular Proteases
  • 1.2.1. Matrix Metalloproteinases1.2.2. Cysteine Cathepsins
  • 1.2.3. Kallikreins
  • 2. Organism and Cancer Degradomes
  • 3. Tumor-Associated Peptidomics
  • 4. Tumor Proteases Relative Peptide in Cancer Detection
  • 5. Conclusion
  • References
  • Chapter Two: The Peptidome Comes of Age: Mass Spectrometry-Based Characterization of the Circulating Cancer Peptidome
  • 1. Introduction
  • 2. Biological Role of Peptides
  • 3. Peptidomics: The Study of Physiological Peptides
  • 4. Mass Spectrometry and Top/Middle-Down Proteomics
  • 4.1. Mass Spectrometry Technology Developments for Peptidomics4.2. Top-Top-Down or Native Mass Spectrometry
  • 4.3. Top-Down-Based Mass Spectrometric Imaging
  • 5. Strategies to Enrich the Peptidome
  • 5.1. Selective Precipitation
  • 5.2. Centrifugal Ultrafiltration
  • 5.3. Capillary Ultrafiltration
  • 5.4. Surface-Derivatised Magnetic Beads
  • 5.5. Nanoporous Substrates
  • 6. Application of Peptidomics in Cancer Biomarker Discovery
  • 6.1. Role of Peptidomics as in Cancer Biomarker Discovery
  • 6.2. Peptidomics and Cancer Diagnosis
  • 6.3. Plasma Protein/Peptide Profiling6.4. The Plasma Interactome
  • 6.5. Endoproteolytic Cleavage
  • 6.6. Exoproteolytic Cleavage
  • 7. Data Processing and Informatics for Peptidome Analyses
  • 7.1. Sequence Databases
  • 7.2. Data Analyses
  • 7.3. Data Repository
  • 8. Emerging Technologies
  • 9. Future Perspectives
  • Acknowledgments
  • References
  • Chapter Three: Peptide Hormones as Tumor Markers in Clinical Practice
  • 1. Introduction
  • 2. Selected Peptide Hormones as Tumor Markers
  • 2.1. Calcitonin
  • 2.1.1. Biosynthesis From Prohormone
  • 2.1.2. Clinical Significance as Tumor Marker2.2. Alpha- and Beta-hCG
  • 2.2.1. Processing of hCG
  • 2.2.2. Clinical Applications as Tumor Markers
  • 2.3. Insulin and C-Peptide
  • 2.3.1. Biosynthesis From Prohormone
  • 2.3.2. Clinical Significance as Tumor Marker
  • 2.4. PTHrp
  • 2.4.1. Biosynthesis From Prohormone
  • 2.4.2. Clinical Significance as Tumor Marker
  • 2.5. Gastrin
  • 2.5.1. Biosynthesis From Prohormone
  • 2.5.2. Clinical Significance as Tumor Marker
  • 2.6. VIP
  • 2.6.1. Biosynthesis From Prohormone

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