Selenium and Selenoproteins in Cancer /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Tew, Kenneth D. (Editor ), Galli, Francesco (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2017.
Edición:First edition.
Colección:Advances in cancer research ; v. 136.
Temas:
Cancer > Treatment.
Selenium > Physiological effect.
Selenoproteins > Physiological effect.
Selenium.
Selenoproteins.
Neoplasms > therapy
Neoplasms
Selenium
Selenoproteins
Cancer > Traitement.
S�el�enium > Effets physiologiques.
S�el�enoprot�eines > Effets physiologiques.
S�el�enium.
S�el�enoprot�eines.
selenium.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Cancer > Treatment
Selenium > Physiological effect
Internet Resources.
Charts.
Index not Present.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Selenium and Selenoproteins in Cancer
  • Copyright
  • Contents
  • Contributors
  • Preface
  • Chapter One: The Epidemiology of Selenium and Human Cancer
  • 1. Introduction
  • 2. Selenium and Cancer: Scope of Research
  • 3. Observational Studies
  • 4. Randomized Controlled Trials
  • 5. The Nutritional Prevention of Cancer Trial
  • 6. The Selenium and Vitamin E Cancer Prevention Trial
  • 7. The Other Trials
  • 8. A Natural Experiment on Selenium and Cancer
  • 9. Selenium in Cancer Therapy
  • 10. Conclusion
  • Acknowledgments
  • References
  • Chapter Two: Selenoproteins in Tumorigenesis and Cancer Progression1. Introduction
  • 2. Selenoprotein Production
  • 3. Investigating Selenoproteins Through Sec tRNA Mutations
  • 4. Role of Specific Selenoproteins in Tumorigenesis
  • 4.1. Selenoprotein P
  • 4.2. Glutathione Peroxidases
  • 4.3. Thioredoxin Reductases
  • 4.4. Selenoprotein F
  • 5. Considerations and Conclusions
  • Acknowledgments
  • References
  • Chapter Three: Selenoproteins and Metastasis
  • 1. Introduction
  • 2. Metastasis
  • 2.1. Local Invasion
  • 2.2. Intravasation
  • 2.3. Survival in Vasculature, Extravasation, and Formation of Micrometastases3. Dietary Selenium and Selenium Supplementation
  • 4. Thioredoxin Reductases and Redox Tone
  • 5. GPX and ROS Regulation
  • 6. Selenoproteins Involved in ER Stress and Calcium Flux
  • 7. Other Potential Roles for Selenoproteins in Metastasis
  • 8. Conclusions
  • Acknowledgments
  • References
  • Chapter Four: Selenium-Dependent Glutathione Peroxidases During Tumor Development
  • 1. Introduction
  • 2. Expression Profile of Se-Dependent GPxes in Different Types of Tumors
  • 3. Hydroperoxides and Redox Signaling During Cancer Development4. Impact of Individual GPxes on Tumor Development
  • 4.1. GPx1
  • 4.1.1. Cell Death
  • 4.1.2. Redox Signaling
  • 4.1.3. Metabolism
  • 4.2. GPx2
  • 4.2.1. Cell Death
  • 4.2.2. Redox Signaling
  • 4.3. GPx3
  • 4.3.1. Cell Death
  • 4.3.2. Redox Signaling
  • 4.4. GPx4
  • 4.4.1. Cell Death
  • 4.4.2. Redox Signaling
  • 5. Conclusions
  • Acknowledgment
  • References
  • Chapter Five: Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy
  • 1. Introduction
  • 1.1. The Thioredoxin System1.2. Thioredoxin Reductase 1
  • 2. TrxR1 as an Important Enzyme in Cancer
  • 3. Conclusions
  • Acknowledgments
  • References
  • Chapter Six: The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium
  • 1. Tumor Microenvironment: Interplay With Immune Cells and Pathways of Inflammation
  • 2. Selenium-Dependent Effects on Cancer Stem Cells in Leukemia
  • 3. Interaction of LSCs With Immune Cells Mediated by CyPGs
  • 4. Targeting LSC Metabolism With Selenium
  • 5. Summary
  • Acknowledgments

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