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003 OCoLC
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008 171020s2017 mauad ob 000 0 eng d
040 |a IDEBK  |b eng  |e rda  |e pn  |c IDEBK  |d N$T  |d EBLCP  |d YDX  |d OPELS  |d OHS  |d OCLCO  |d MEU  |d UAB  |d OCLCO  |d UPM  |d D6H  |d OCLCF  |d OCLCO  |d OCLCQ  |d DKU  |d OCLCO  |d AU@  |d OCLCO  |d OCLCA  |d OCLCQ  |d OCLCO  |d OCLCQ  |d CASUM  |d OCL  |d OCLCO 
019 |a 1007310184 
020 |a 0128120177  |q (electronic bk.) 
020 |a 9780128120170  |q (electronic bk.) 
020 |a 9780128120163 
020 |a 0128120169 
035 |a (OCoLC)1007224849  |z (OCoLC)1007310184 
050 4 |a RC270.8  |b .S454 2017eb 
072 7 |a HEA  |x 039000  |2 bisacsh 
072 7 |a MED  |x 014000  |2 bisacsh 
072 7 |a MED  |x 022000  |2 bisacsh 
072 7 |a MED  |x 112000  |2 bisacsh 
072 7 |a MED  |x 045000  |2 bisacsh 
082 0 4 |a 616.99406  |2 23 
245 0 0 |a Selenium and Selenoproteins in Cancer /  |c edited by Kenneth D. Tew, Francesco Galli. 
250 |a First edition. 
264 1 |a Cambridge, MA :  |b Academic Press,  |c 2017. 
300 |a 1 online resource (xiv, 302 pages) :  |b illustrations (some color), charts 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a Advances in cancer research ;  |v v. 136 
546 |a Text in English. 
504 |a Includes bibliographical references. 
505 0 |a Front Cover -- Selenium and Selenoproteins in Cancer -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: The Epidemiology of Selenium and Human Cancer -- 1. Introduction -- 2. Selenium and Cancer: Scope of Research -- 3. Observational Studies -- 4. Randomized Controlled Trials -- 5. The Nutritional Prevention of Cancer Trial -- 6. The Selenium and Vitamin E Cancer Prevention Trial -- 7. The Other Trials -- 8. A Natural Experiment on Selenium and Cancer -- 9. Selenium in Cancer Therapy -- 10. Conclusion -- Acknowledgments -- References 
505 8 |a Chapter Two: Selenoproteins in Tumorigenesis and Cancer Progression1. Introduction -- 2. Selenoprotein Production -- 3. Investigating Selenoproteins Through Sec tRNA Mutations -- 4. Role of Specific Selenoproteins in Tumorigenesis -- 4.1. Selenoprotein P -- 4.2. Glutathione Peroxidases -- 4.3. Thioredoxin Reductases -- 4.4. Selenoprotein F -- 5. Considerations and Conclusions -- Acknowledgments -- References -- Chapter Three: Selenoproteins and Metastasis -- 1. Introduction -- 2. Metastasis -- 2.1. Local Invasion -- 2.2. Intravasation 
505 8 |a 2.3. Survival in Vasculature, Extravasation, and Formation of Micrometastases3. Dietary Selenium and Selenium Supplementation -- 4. Thioredoxin Reductases and Redox Tone -- 5. GPX and ROS Regulation -- 6. Selenoproteins Involved in ER Stress and Calcium Flux -- 7. Other Potential Roles for Selenoproteins in Metastasis -- 8. Conclusions -- Acknowledgments -- References -- Chapter Four: Selenium-Dependent Glutathione Peroxidases During Tumor Development -- 1. Introduction -- 2. Expression Profile of Se-Dependent GPxes in Different Types of Tumors 
505 8 |a 3. Hydroperoxides and Redox Signaling During Cancer Development4. Impact of Individual GPxes on Tumor Development -- 4.1. GPx1 -- 4.1.1. Cell Death -- 4.1.2. Redox Signaling -- 4.1.3. Metabolism -- 4.2. GPx2 -- 4.2.1. Cell Death -- 4.2.2. Redox Signaling -- 4.3. GPx3 -- 4.3.1. Cell Death -- 4.3.2. Redox Signaling -- 4.4. GPx4 -- 4.4.1. Cell Death -- 4.4.2. Redox Signaling -- 5. Conclusions -- Acknowledgment -- References -- Chapter Five: Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy -- 1. Introduction 
505 8 |a 1.1. The Thioredoxin System1.2. Thioredoxin Reductase 1 -- 2. TrxR1 as an Important Enzyme in Cancer -- 3. Conclusions -- Acknowledgments -- References -- Chapter Six: The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium -- 1. Tumor Microenvironment: Interplay With Immune Cells and Pathways of Inflammation -- 2. Selenium-Dependent Effects on Cancer Stem Cells in Leukemia -- 3. Interaction of LSCs With Immune Cells Mediated by CyPGs -- 4. Targeting LSC Metabolism With Selenium -- 5. Summary -- Acknowledgments 
650 0 |a Cancer  |x Treatment. 
650 0 |a Selenium  |x Physiological effect. 
650 0 |a Selenoproteins  |x Physiological effect. 
650 0 |a Selenium. 
650 0 |a Selenoproteins. 
650 2 |a Neoplasms  |x therapy  |0 (DNLM)D009369Q000628 
650 2 |a Neoplasms  |0 (DNLM)D009369 
650 2 |a Selenium  |0 (DNLM)D012643 
650 2 |a Selenoproteins  |0 (DNLM)D051140 
650 6 |a Cancer  |x Traitement.  |0 (CaQQLa)201-0004693 
650 6 |a S�el�enium  |x Effets physiologiques.  |0 (CaQQLa)201-0028158 
650 6 |a S�el�enoprot�eines  |0 (CaQQLa)000286271  |x Effets physiologiques.  |0 (CaQQLa)201-0374337 
650 6 |a S�el�enium.  |0 (CaQQLa)201-0005075 
650 6 |a S�el�enoprot�eines.  |0 (CaQQLa)000286271 
650 7 |a selenium.  |2 aat  |0 (CStmoGRI)aat300156319 
650 7 |a HEALTH & FITNESS  |x Diseases  |x General.  |2 bisacsh 
650 7 |a MEDICAL  |x Clinical Medicine.  |2 bisacsh 
650 7 |a MEDICAL  |x Diseases.  |2 bisacsh 
650 7 |a MEDICAL  |x Evidence-Based Medicine.  |2 bisacsh 
650 7 |a MEDICAL  |x Internal Medicine.  |2 bisacsh 
650 7 |a Selenoproteins  |2 fast  |0 (OCoLC)fst01736533 
650 7 |a Selenium  |2 fast  |0 (OCoLC)fst01111403 
650 7 |a Cancer  |x Treatment  |2 fast  |0 (OCoLC)fst00845538 
650 7 |a Selenium  |x Physiological effect  |2 fast  |0 (OCoLC)fst01111412 
655 4 |a Internet Resources. 
655 4 |a Charts. 
655 4 |a Index not Present. 
700 1 |a Tew, Kenneth D.,  |e editor. 
700 1 |a Galli, Francesco,  |e editor. 
776 0 8 |i Print version:  |t Selenium and Selenoproteins in Cancer.  |b First edition.  |d Cambridge, MA : Academic Press, 2017  |z 9780128120163  |z 0128120169  |w (OCoLC)982089162 
830 0 |a Advances in cancer research ;  |v v. 136. 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/bookseries/0065230X/136  |z Texto completo