Tabla de Contenidos:
  • The extended evolutionary synthesis and addiction: the price we pay for adaptability
  • The Dopamine Theory of Addiction
  • Substance Use in Animals and Humans
  • Psychiatric Comorbidity
  • Dopamine and Impulsivity
  • Human Flexibility, Adaptability, and Innovation
  • Pleiotropy
  • The EES and Addiction
  • Discussion
  • Conclusion
  • Cross-talk between the epigenome and neural circuits in drug addiction
  • Drug Addiction Is a Behavioral Learning Disorder
  • Drug-Induced Plasticity: How Is Drug-Associated Information Stored for Long Periods of Time in the Brain?
  • The Neural Circuits Controlling Motivated Behaviors and Their Dysregulation in Drug Addiction
  • How Are Changes in Neural Morphology and Function Maintained?
  • Epigenetic Regulation Is the Key to a Central Property of Neural Networks: Plasticity
  • The Interface Between Neuronal Activation and Epigenetic Remodeling
  • Bidirectional Cross-Talk Between the Epigenome and Cellular Activity
  • Focusing to the Future
  • Addiction: A dysregulation of satiety and inflammatory processes
  • Brief Summaries of Selected Theories of Addiction
  • Brain Circuitry and Areas Involved in Addiction
  • Drug-Induced Alterations in Dopamine Neurotransmission
  • Changes in Dopamine Signaling May Mediate Addictive Behavior
  • Regulation of Satiety
  • The Hypothalamus: The Intersect Between Addiction and Satiety
  • Inflammation and Addiction
  • Conclusion
  • Corticostriatal plasticity, neuronal ensembles, and regulation of drug-seeking behavior
  • Introduction: Ensembles in Addiction
  • Constitutive Changes Induced by Drugs of Abuse
  • Glutamate Spillover and Transient Synaptic Plasticity, Common to All Drugs of Abuse
  • Could the t-SP Be Embedded in a Neuronal Network Specific to Drug Seeking?
  • Paraventricular thalamus: Gateway to feeding, appetitive motivation, and drug addiction
  • Anatomical Organization of the PVT Within a Motivational Framework
  • PVT and Appetitive Motivation
  • PVT in Drug Taking, Withdrawal, and Relapse
  • Conclusions
  • Functional roles of orexin/hypocretin receptors in reward circuit
  • Reward and Reward Processing
  • Reward Processing and Drug Abuse
  • Reward Promotion
  • Conclusion.