Natural variation and clocks /

Natural Variances and Clocks provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs and advances. This updated release includes chapters on a variety of new research, including the Natural variation of the circadian clock in Neurospora, Natura...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Goodwin, Stephen F. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2017.
Edición:First edition.
Colección:Advances in genetics ; v. 99.
Temas:
Genetics > Research.
Circadian rhythms.
Variation (Biology)
Biological rhythms.
Medical genetics.
Neurosciences.
Circadian Rhythm
Neurosciences
Genetics, Medical
Rythmes circadiens.
Variation (Biologie)
G�en�etique m�edicale.
SCIENCE > Life Sciences > Evolution.
Biological rhythms
Circadian rhythms
Genetics > Research
Medical genetics
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Natural Variation and Clocks
  • Copyright
  • Contents
  • Contributors
  • Preface
  • Chapter One: Natural Variation of the Circadian Clock in Neurospora
  • 1. Introduction
  • 2. Neurospora in Nature
  • 2.1. The Genus of Neurospora
  • 2.2. Natural Habitats
  • 2.3. Collection of Neurospora Ecotypes
  • 2.4. Neurospora as a Model for Clock Variation Studies
  • 3. The Circadian Clock of Neurospora
  • 3.1. FRQ-Dependent Oscillators
  • 3.1.1. Simple and Coupled Loops
  • 3.1.1.1. Positive Regulation of WC-1
  • 3.1.1.2. Coupled Loops in WCC
  • 3.1.1.3. Negative Regulation of FRQ3.1.2. Interlocked Loops in WCC/FRQ
  • 3.1.2.1. Negative Feedback Loop
  • 3.1.2.2. Positive Feedback Loop
  • 3.1.3. Posttranslational Modification of WCC and FFC
  • 3.1.4. Negative Feedback Loop in WCC/FRQ/VVD
  • 3.2. FRQ-Independent Oscillators
  • 4. Natural Variation and the Circadian Clock
  • 4.1. Natural Variation in Neurospora Ecotypes
  • 4.2. Natural Variation of Core Clock Genes
  • 4.3. Technical Challenges for Studying Clock Variation in Neurospora Natural Populations
  • 4.4. Methods for Clock Variation Studies
  • 4.4.1. QTL Analysis on Clock Phenotypes4.4.2. Circadian Clocks in Natural Substrates and Natural Environment
  • 5. Future Challenges
  • 6. Concluding Remarks
  • Acknowledgments
  • References
  • Chapter Two: Natural Variation and Genetics of Photoperiodism in Wyeomyia smithii
  • 1. Introduction
  • 1.1. Raison d�a#x80;#x99;�A�tre of Photoperiodism
  • 1.2. Geographic Clines
  • 1.3. Photoperiodism in Wyeomyia smithii
  • 1.3.1. Photoperiodism and Phylogeography
  • 1.3.2. Geography of Photoperiodic Response
  • 2. Genetics of Photoperiodic Response
  • 2.1. Genetic Potential to Respond to Selection2.2. Hidden Genetic Variation
  • 2.2.1. Genotype by Environment Interaction
  • 2.2.2. Dominance and Epistasis
  • 2.3. Mapping Genotype to Phenotype
  • 2.4. Lessons From Quantitative Genetic Approaches in Wyeomyia smithii
  • 3. Photoperiodism and Climate Change
  • 4. Photoperiodism and Circadian Rhythmicity
  • 4.1. Functionality, Definitions, and the Evolutionary Perspective
  • 4.2. Daily vs Seasonal Timing
  • 4.2.1. B�A�nning�a#x80;#x99;s Proposition Then and Subsequently
  • 4.2.2. How W. smithii Assesses Day Length
  • 4.2.3. Resonance4.3. Molecular Connections and Pleiotropy
  • 5. Conclusions
  • Acknowledgments
  • References
  • Chapter Three: Natural Variation in Human Clocks
  • 1. Introduction
  • 2. Direct Measurement of Human Period
  • 3. Proxies of Human Period
  • 4. Extremes of Human Circadian Period
  • 5. Genetic Control of Circadian Rhythms in Mammals
  • 6. Genetic Studies of Circadian Rhythm Sleep Disorders
  • 7. Genetic Associations With Measured Behavioral Rhythms
  • 8. Single-Gene Association Studies of Questionnaire-Determined Human Chronotype

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