GERD : a new understanding of pathology, pathophysiology, and treatment /

GERD: A New Understanding of Pathology, Pathophysiology, and Treatment transforms the assessment of gastroesophageal reflux disease (GERD) from its present state, which is largely dependent on clinical definition and management, to a more objective scientific basis that depends on pathologic assessm...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Chansoma, Parakrama T. (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, [2018]
Temas:
Gastroesophageal reflux.
Gastroesophageal Reflux
Reflux gastro-�sophagien.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Gastroesophageal reflux
Internet Resources.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • GERD
  • Dedication
  • GERDA: New Understanding of Pathology, Pathophysiology, and Treatment
  • Copyright
  • Contents
  • Acknowledgments
  • Introduction: Discovery: A Path to a New Solution for Gastroesophageal Reflux Disease
  • 1. STATEMENT OF CONFLICT OF INTERESTS
  • 2. PERIOD UP TO 1990: NO INTEREST IN DISCOVERY
  • 3. THE DISCOVERY: 1990 TO THE PRESENT
  • 3.1 The Material on Which Expertise Was Developed
  • 3.2 Cardiac Epithelium Does Not Exist Normally
  • 3.3 Autopsy Studies of the Region
  • 3.4 The Normal Histologic State of the Esophagus and Stomach: The Zero Squamooxyntic Gap93.5 A Cellular Definition of Gastroesophageal Reflux Disease
  • 3.6 Location of Cardiac Mucosa: Definition of the True Gastroesophageal Junction and the Definition of the Dilated Distal Esophagus
  • 3.7 Correlation Between the Dilated Distal Esophagus and Damage to the Lower Esophageal Sphincter
  • 4. ACCEPTANCE OF THE NEW CONCEPTS
  • 4.1 The Value of Clinical Research
  • 4.2 Impossible Contradictions
  • 4.3 My Responsibility for the Failure of Acceptance
  • 4.4 The Reason for This Book5. THE FUTURE THAT I HOPE FOR
  • REFERENCES
  • 1
  • Definition of Gastroesophageal Reflux Disease: Past, Present, and Future
  • 1. POTENTIAL CRITERIA TO DEFINE GASTROESOPHAGEAL REFLUX DISEASE
  • 1.1 Symptoms of Gastroesophageal Reflux Disease
  • 1.2 The Empiric Proton Pump Inhibitor Test
  • 1.3 Tests Based on Quantitating Gastroesophageal Reflux
  • 1.4 Gross, Radiologic, and Endoscopic Mucosal Abnormalities Caused by Reflux
  • 1.5 Cellular (Histopathologic) Changes Caused by Reflux
  • 1.6 Criteria Based on Molecular (Genetic) Changes
  • 1.7 Criteria Based on Detecting Lower Esophageal Sphincter Damage, the Cause of Gastroesophageal Reflux Disease (Fig. 1.7)2. PAST DEFINITIONS OF GASTROESOPHAGEAL REFLUX DISEASE BASED ON ULCERS AND EROSIONS
  • 3. PRESENT (SYMPTOM-BASED) DEFINITIONS OF GASTROESOPHAGEAL REFLUX DISEASE
  • 3.1 Common Unstandardized Definition of Gastroesophageal Reflux Disease in Practice
  • 3.2 The Genval Working Group Definition, 1999
  • 3.3 The Montreal Definition and Classification of Gastroesophageal Reflux Disease, 200624
  • 4. PROBLEMS WITH PRESENT SYMPTOM-BASED DEFINITION
  • 4.1 An Illusion of �a#x80;#x9C;Cure�a#x80;#x9D; of Gastroesophageal Reflux Disease4.2 Unnecessary Use of Proton Pump Inhibitors
  • 4.3 Lack of Effort to Prevent Progression to Failure of Symptom Control in Gastroesophageal Reflux Disease
  • 4.4 Failure to Prevent Esophageal Adenocarcinoma (Fig. 1.8)
  • 4.5 Absence of Alternatives to Treating Gastroesophageal Reflux Disease
  • 5. A NEW CELLULAR DEFINITION OF GASTROESOPHAGEAL REFLUX DISEASE
  • 5.1 Pathogenesis of Gastroesophageal Reflux Disease
  • 5.2 Reflux Esophagitis and Reflux Carditis

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