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Role of nutraceuticals in cancer chemosensitization /
Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on nutraceuticals, the compounds derived from natural sources, which are usually multi-targeted as a means to overcome chemoresistance. This book discusses the role of several compounds related to nutraceuticals and chemoresist...
| Clasificación: | Libro Electrónico |
|---|---|
| Autores principales: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom :
Academic Press,
[2018]
|
| Edición: | First edition. |
| Colección: | Cancer sensitizing agents for chemotherapy ;
v. 2. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover
- Cancer Sensitizing Agents for Chemotherapy: Role of Nutraceuticals in Cancer Chemosensitization
- Copyright
- Contents
- Contributors
- About the Editors
- About the Series Editor
- Aims and Scope for Series �a#x80;Cancer Sensitizing Agents for Chemotherapy�a#x80;#x9D;
- Preface
- Chapter 1: Pathways Linked to Cancer Chemoresistance and Their Targeting by Nutraceuticals
- Introduction
- Chemotherapy
- Alkylating Agents
- Cell Cycle Inhibitors/Antimicrotubule Agents
- Antimetabolites
- Antibiotics
- Topoisomerase Inhibitors
- Targeted TherapyTarget-Specific Antibodies
- Small Molecule Inhibitors
- Chemoresistance: Problem in Curing Cancer
- Mechanism of Chemoresistance
- Drug Transporters
- Enhanced DNA Repair System
- Drug Inactivation
- Altered Drug Targets
- Epithelial-Mesenchymal Transition
- Inhibition of Apoptosis
- Autophagy
- Aberrant Expression and Constitutive Activation of Transcription Factors
- Nuclear Factor-Kappa B (NF-�I�B)
- Signal Transducers and Activators of Transcription 3 (STAT-3)
- Activating Protein-1 (AP-1)
- Activation of Self-Renewal PathwaysChemosensitization: An Approach to Target Cancer
- Nutraceuticals as Chemosensitizers: Opportunities and Challenges
- Conclusion
- Conflict of Interest
- Acknowledgments
- References
- Chapter 2: The Potential of Curcumin: A Multitargeting Agent in Cancer Cell Chemosensitization
- Introduction
- Molecular Targets of Curcumin
- Chemosensitization Studies of Curcumin in Different Cancers
- Curcumin Mediated Chemosensitization in Bladder Cancer
- Curcumin Mediated Chemosensitization in Brain Cancer
- Curcumin Mediated Chemosensitization in Breast CancerCurcumin Mediated Chemosensitization in Cervical Cancer
- Curcumin Mediated Chemosensitization in Colon Cancer
- Curcumin Mediated Chemosensitization in Esophageal Cancer
- Curcumin Mediated Chemosensitization in Leukemia
- Curcumin Mediated Chemosensitization in Lung Cancer
- Curcumin Mediated Chemosensitization in Multiple Myeloma
- Curcumin Mediated Chemosensitization in Ovarian Cancer
- Curcumin Mediated Chemosensitization in Pancreatic Cancer
- Curcumin Mediated Chemosensitization in Prostate Cancer
- Curcumin Mediated Chemosensitization in Other CancersHybrid Curcumin
- Conclusion
- Conflict of Interest
- Acknowledgment
- References
- Further Reading
- Chapter 3: Role of Resveratrol in Chemosensitization of Cancer
- Introduction
- Source and Chemistry of Resveratrol
- Possible Molecular Mechanisms of Chemoresistance in Cancer
- ATP-Dependent Drug Efflux
- Drug Detoxification
- Alterations in Drug Target Molecules
- Alterations in DNA Damage Repair Pathways
- Regulation of Cell Cycle Arrest
- Regulation of Apoptosis