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|a Current topics in membranes :
|b sterol regulation of ion channels /
|c edited by Irena Levitan.
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| 264 |
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1 |
|a Cambridge, Massachusetts ;
|a London, England :
|b Academic Press,
|c 2017.
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| 264 |
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4 |
|c �2017
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| 300 |
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|a 1 online resource (308 pages)
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Current topics in membranes ;
|v v. 80
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0 |
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|a Front Cover; Sterol Regulation of Ion Channels; Copyright; Contents; Contributors; Preface; Acknowledgments; Section 1: Membrane Structure and General Mechanisms of Sterol Regulation of Ion Channels; Chapter One: Relevance of CARC and CRAC Cholesterol-Recognition Motifs in the Nicotinic Acetylcholine Receptor and Other ... ; 1. Introduction; 2. Experimental Validation of the CARC Motif; 3. Coexistence of CARC and CRAC Sequences Within the Same TM Domain; 4. Reliability of the CARC and CRAC Algorithms; 5. Cholesterol and Its Key Role in Liquid-Ordered Lipid Domains
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| 505 |
8 |
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|a 6. Evolutionary Conservation of Sterol-Recognition MotifsAcknowledgments; References; Chapter Two: Differential Effects of Sterols on Ion Channels: Stereospecific Binding vs Stereospecific Response; 1. Introduction; 2. Physical Properties of Membrane Bilayer: Sterol Analysis; 2.1. 3D Sterol Structure of Cholesterol Chiral Analogues; 2.2. Position Within the Bilayer; 2.3. Lipid Order and Packing; 3. Differential Effects of Sterols on the Ion Channel Function: Prevalence of Stereospecific Effects; 3.1. Stereospecific Effects of Cholesterol on Ion Channels
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| 505 |
8 |
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|a 3.1.1. Inwardly Rectifying K+ (Kir) Channels3.1.2. Large-Conductance Ca2+-Sensitive Voltage-Gated K+ Channels (BK); 3.1.3. Transient Receptor Potential Vanilloid 1 (TRPV1) Channels; 3.1.4. GABAA Receptors; 3.2. Nonstereospecific Effects of Cholesterol on Ion Channels; 3.2.1. Nicotinic Acetylcholine Receptor (nAChR); 3.2.2. Volume-Regulated Anion Channels (VRACs); 4. Evidence for Direct Binding and Sterol Competition for the Binding Sites: Kir Channels; 4.1. Challenges of the Approach; 4.2. Cholesterol Binding to KirBac1.1 Channels Is Not Stereospecific
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| 505 |
8 |
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|a 5. Computational Analysis of the Stereospecificity of Cholesterol Binding to Ion Channels6. Conclusions and Future Directions; Acknowledgments; References; Section 2: Structural Determinants of Cholesterol-Ion Channels Interactions; Chapter Three: Regulation of Ca2+-Sensitive K+ Channels by Cholesterol and Bile Acids via Distinct Channel Subunits and Sites; 1. Biology and Chemistry of Cholesterol and Bile Acids; 1.1. Cholesterol in Physiology and Disease; 1.2. Bile Acids in Physiology and Disease; 1.3. Connections in the Chemistry and Metabolism of Cholesterol and Bile Acids
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| 505 |
8 |
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|a 1.4. Evidence for Direct Interactions Between Cholesterol and Ion Channel Proteins1.5. Evidence for Direct Interactions Between Bile Acids and Ion Channel Proteins; 2. Modulation of BK Channels by Cholesterol or Bile Acids; 2.1. Voltage- and Ca2+-Gated, Large Conductance K+ (BK) Channels; 2.2. Cholesterol and BK Channel-Mediated Currents; 2.3. Mechanisms Underlying Cholesterol Modulation of BK Channel Activity; 2.3.1. Mechanisms Driven by Changes in the Physicochemical Properties of the Lipid Bilayer; 2.3.2. Direct Cholesterol-BK Protein Interactions
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| 650 |
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|a Ion channels.
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| 650 |
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0 |
|a Sterols.
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| 650 |
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2 |
|a Ion Channels
|0 (DNLM)D007473
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| 650 |
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2 |
|a Sterols
|0 (DNLM)D013261
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| 650 |
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6 |
|a Canaux ioniques.
|0 (CaQQLa)201-0145111
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| 650 |
|
6 |
|a St�erols.
|0 (CaQQLa)201-0086157
|
| 650 |
|
7 |
|a SCIENCE
|x Life Sciences
|x Anatomy & Physiology.
|2 bisacsh
|
| 650 |
|
7 |
|a Ion channels
|2 fast
|0 (OCoLC)fst00978573
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| 650 |
|
7 |
|a Sterols
|2 fast
|0 (OCoLC)fst01133283
|
| 700 |
1 |
|
|a Levitan, Irena,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|t Current topics in membranes.
|d Cambridge, Massachusetts ; London, England : Academic Press, 2017
|z 9780128093887
|z 0128093889
|w (OCoLC)985078868
|
| 830 |
|
0 |
|a Current topics in membranes ;
|v v. 80.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/10635823/80
|z Texto completo
|
