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Endocrine biomarkers : clinicians and clinical chemists in partnership /
Endocrine Biomarkers: Clinical Aspects and Laboratory Determination covers all the pre-analytical variables that can affect test results, both in the clinic and laboratory. Biomarkers of endocrine and bone diseases are discussed from both clinical and laboratory perspectives, and the authors elabora...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam, Netherlands :
Elsevier,
2017.
|
| Colección: | Clinical aspects and laboratory determination of biomarkers series ;
v. 3. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Endocrine Biomarkers; Copyright Page; Dedication; Contents; List of Contributors; Preface; Who Needs This Book and Why; 1 Variables affecting endocrine tests results, errors prevention and mitigation; 1.1 Introduction; 1.2 Preanalytical Variables; 1.3 Analytical Variables; 1.4 Postanalytical Variables; 1.5 Complete Test Process; 1.6 Preanalytical; 1.6.1 Physician Visits and Test Ordering; 1.6.1.1 Patient physiology; 1.6.1.2 Patient specimen; 1.6.1.3 Specimen collection area; 1.6.1.4 Patient test entry; 1.6.2 Sites of Blood Collection; 1.6.2.1 Venous blood collection
- 1.6.2.2 Skin puncture blood collection1.6.2.3 Arterial blood collection; 1.6.2.4 Blood collection from intravenous lines and catheters; 1.6.3 Blood Specimen Classifications; 1.6.3.1 Whole blood; 1.6.3.2 Dried blood spots; 1.6.3.3 Serum; 1.6.3.4 Plasma; 1.6.4 Blood Collection Tubes; 1.6.4.1 Order of draw; 1.6.4.2 Anticoagulants; 1.6.4.3 Serum separator gel; 1.6.4.4 Tube materials; 1.6.4.5 Hemolysis; 1.6.5 Specimen Processing, Transfer, and Storage; 1.7 Analytical; 1.7.1 Important Issues in Immunoassays; 1.7.1.1 Immunoassay techniques; 1.7.1.2 Immunoassay interferences
- 1.7.1.3 Biotin interferences in the clinical laboratory1.7.1.4 Alternative testing methods; 1.8 Clinical Applications of Valid Laboratory Results; 1.8.1 Consideration of Clinical Application of Results Should Precede Ordering the Test; 1.8.2 Clinicians Should Seek Advice From Specialists Prior to Ordering Tests With Which They Are Unfamiliar; 1.8.3 Test Sensitivity; 1.8.4 Test Specificity and Sensitivity; 1.8.5 Positive and Negative Predictive Values; 1.8.5.1 Spectrum bias; 1.8.6 Screening and Confirmatory Tests
- 1.8.7 Accuracy and Precision Applied to Clinical Decision Making Around Fixed Biochemical Targets or Thresholds1.9 The Endocrinologist-Chemist Relationship; References; 2 Thyroid disorders; 2.1 Overview; 2.1.1 Clinical Epidemiology of Thyroid Functional Disorders; 2.1.2 Basic Thyroid Physiology; 2.1.3 Overview Perspective: Thyroid Disorders-Disease State or Statistical Outlier?; 2.2 Hypothyroidism: Clinical Picture; 2.2.1 Causes; 2.2.2 Special Situations: Pediatrics, Pregnancy, and Critical Illness; 2.2.2.1 Congenital hypothyroidism; 2.2.2.2 Gestational thyroid changes
- 2.2.2.3 Critical illness2.2.3 Rare Situations: Pituitary Disease, Medications, and Tumors; 2.2.3.1 Pituitary disease; 2.2.3.2 Medications; 2.2.3.3 "Consumptive" hypothyroidism; 2.2.4 Diagnostic Approach; 2.2.4.1 Thyroid-stimulating hormone is always the first step; 2.2.4.2 Sometimes freeT4 is needed; 2.2.4.3 Thyroid auto-antibodies; 2.2.4.4 Pediatric considerations/newborn screening; 2.2.4.5 Pregnancy; 2.2.5 Diagnostic Definitions; 2.2.5.1 Secondary hypothyroidism (pituitary disease); 2.2.5.2 Diagnosis in pregnancy