MiRNAs in Differentiation and Development /

'MiRNAs in Differentiation and Development', the latest in the 'International Review of Cell and Molecular Biology' series, reviews and details current advances in cell and molecular biology.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Galluzzi, Lorenzo (Editor ), Vitale, Ilio (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, 2017.
Colección:International review of cell and molecular biology ; v. 333.
Temas:
MicroRNA.
MicroARN.
SCIENCE > Life Sciences > Biochemistry.
Acceso en línea:Texto completo

MARC

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245 0 0 |a MiRNAs in Differentiation and Development /  |c edited by Lorenzo Galluzzi and Ilio Vitale. 
264 1 |a London :  |b Academic Press,  |c 2017. 
300 |a 1 online resource (x, 323 pages :  |b illustrations (some color)) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
546 |a Text in English. 
504 |a Includes bibliographical references. 
588 0 |a Print version record. 
505 0 |a Front Cover; MiRNAs in Differentiation and Development; Copyright; Contents; Contributors; Chapter One: MicroRNAs in DNA Damage Response, Carcinogenesis, and Chemoresistance; 1. Introduction; 2. MiRNA Regulation in Response to DNA Damage; 2.1. Transcriptional Regulation of MiRNAs; 2.2. Posttranscriptional Regulation of MiRNAs; 3. DNA Damage Response Regulation by MiRNAs; 3.1. Sensors of DNA Damage and Mediators of the DNA Damage Response; 3.2. Transducers of the DNA Damage Response; 3.3. Effectors of the DNA Damage Response; 3.3.1. Effectors of Apoptosis; 3.3.2. Effectors of the Cell Cycle 
505 8 |a 3.3.3. Effectors of DNA Repair4. MiRNAs in Cancer; 4.1. MiRNAs as Oncogenes; 4.2. MiRNAs as Tumor Suppressors; 4.3. MiRNAs as Both Oncogenes and Tumor Suppressor Genes; 5. The Role of MiRNAs in Drug Resistance; 5.1. MiRNAs Regulate Drug Resistance Through Survival and/or Apoptosis Pathways; 5.2. MiRNAs Regulate Drug Resistance Through the Drug-Targeting and DNA-Repair Pathways; 5.3. MiRNAs Regulate Drug Resistance Through Regulating Drug Delivery and Drug Metabolism; 5.4. MiRNAs Regulate Drug Resistance in Pharmacogenomics; 6. Conclusion; References 
505 8 |a Chapter Two: MicroRNAs as Key Effectors in the p53 Network1. Introduction; 2. MicroRNAs, Small Helpers With Big Effects in the p53 Pathway; 2.1. p53 Transcriptionally Upregulates MicroRNAs; 2.2. p53 Transcriptionally Downregulates a Subset of MicroRNAs; 2.3. p53 Modulates MicroRNA Maturation and mRNA Accessibility; 2.4. p53 Is a Direct Target of MicroRNAs; 2.5. p53 Is an Indirect Target of MicroRNAs; 3. MicroRNAs Engaged in Fulfilling GOF Activities of Mutant p53; 3.1. MicroRNAs Transcriptionally Regulated by Mutant p53 
505 8 |a 3.2. Mutant p53 Regulates MicroRNA Biogenesis at Posttranscriptional Level4. Conclusions; Acknowledgments; References; Chapter Three: Impact of MicroRNAs in the Cellular Response to Hypoxia; 1. Introduction; 2. Regulation of MiRNA Expression by Hypoxia; 2.1. Control of hypoxamiRs Expression Through HIFs-Dependent Mechanisms; 2.1.1. MiR-210; 2.1.2. Other hypoxamiRs; 2.2. HIF-Independent Transcriptional Regulation of hypoxamiRs; 2.3. Epigenetic Mechanisms; 2.4. Regulation of MiRNA Biogenesis by Hypoxia; 2.5. MiRNA Export and Hypoxia 
505 8 |a 3. The Diverse Roles of MiRNAs in Cellular Adaptation to Hypoxia3.1. The hypoxamiR Targetome: Present and Future; 3.2. Feedback Regulatory Loops Between MiRNAs and Hypoxia; 3.2.1. MiR-210; 3.2.2. Other hypoxamiRs; 3.3. Metabolic Adaptation; 3.3.1. MiR-210; 3.3.2. Other hypoxamiRs; 3.4. Cell Cycle; 3.4.1. MiR-210; 3.4.2. Other hypoxamiRs; 3.5. DNA Repair; 3.5.1. MiR-210; 3.5.2. Other hypoxamiRs; 3.6. Apoptosis; 3.6.1. MiR-210; 3.6.2. Other hypoxamiRs; 3.7. Angiogenesis; 3.7.1. MiR-210; 3.7.2. Other hypoxamiRs; 3.8. Inflammation and Immunity; 3.8.1. MiR-210; 3.8.2. Other hypoxamiRs 
520 8 |a 'MiRNAs in Differentiation and Development', the latest in the 'International Review of Cell and Molecular Biology' series, reviews and details current advances in cell and molecular biology.  |b MiRNAs in Differentiation and Development, Volume 333, the latest in the International Review of Cell and Molecular Biology series, reviews and details current advances in cell and molecular biology. Topics in this updated volume include chapters on the Regulation of the DNA damage response by miRNAs, miRNAs and the p53 network, the Impact of miRNAs in the cellular response to hypoxia, miRNAs in oncogenesis and tumor suppression, and the Role of miRNAs in metastatic dissemination. The IRCMB series has a worldwide readership, maintaining a high standard by publishing articles on timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. This great resource ranks high amongst scientific journals dealing with cell biology. 
650 0 |a MicroRNA. 
650 6 |a MicroARN.  |0 (CaQQLa)000265128 
650 7 |a SCIENCE  |x Life Sciences  |x Biochemistry.  |2 bisacsh 
650 7 |a MicroRNA.  |2 fast  |0 (OCoLC)fst01940234 
700 1 |a Galluzzi, Lorenzo,  |e editor. 
700 1 |a Vitale, Ilio,  |e editor. 
830 0 |a International review of cell and molecular biology ;  |v v. 333. 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/bookseries/19376448/333  |z Texto completo 

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