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Molecular approach to cancer management /
Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London ; San Diego, CA :
Academic Press,
2017.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 003 | OCoLC | ||
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| 020 | |z 9780128128961 | ||
| 020 | |z 0128128968 | ||
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| 072 | 7 | |a HEA |x 039000 |2 bisacsh | |
| 072 | 7 | |a MED |x 014000 |2 bisacsh | |
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| 100 | 1 | |a Sherbet, G. V. |q (Gajanan V.), |e author. | |
| 245 | 1 | 0 | |a Molecular approach to cancer management / |c Gajanan V. Sherbet, Newcastle University, Newcastle upon Tyne, United Kingdom, the Institute for Molecular Medicine, Huntington Beach, CA, United States. |
| 264 | 1 | |a London ; |a San Diego, CA : |b Academic Press, |c 2017. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 500 | |a Includes index. | ||
| 588 | 0 | |a Vendor-supplied metadata. | |
| 520 | |a Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials. This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy. | ||
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Modulation of growth factor signalling in targeted therapy -- The TGF-ss family accessory type III receptor function in cancer progression -- Insulin-like growth factor signalling as a target to control tumour progression -- Angiogenisis in neoplasia and anti-angiogenesis strategy in the control of tumour growth and metastasis -- On the trail of TRAIL (TNF-related apoptosis inducing ligand) in tumour growth and angiogenesis -- Hedgehog (Hh) signalling in EMT (Epithelial Mesenchyme Transition), CSCs (Cancer Stem Cells) and angiogenesis -- Hippo signalling in cell proliferation, migration and angiogenesis -- Notch signalling in carcinogenesis -- Canonical and non-canonical activation of NF-kB in tumorigenesis -- Tumour suppression and inhibition of angiogenesis by TXNIP (Thioredoxin Interacting protein) -- Cyclooxygenase-2 inhibitors suppress EMT, CSCs and angiogenesis -- Endogenous inhibitors of angiogenesis -- Stem cells in cancer therapy -- Inhibitor of DNA-binding proteins in angiogenesis -- Small molecule inhibitors of angiogenesis and cell proliferation -- Suramin and polysulphonated napthylureas as angiogenesis inhibitors -- The anti-cancer potential of flavonoids -- Selenoproteins in cancer control -- Control of tumour growth and angiogenesis by thalidomide and its analogues -- Metaformin and its anti-tumour attributes -- Statins in cancer biology -- Are there gains to be made in exploring anthrax lethal toxin (LeTx) as a tumour and an angiogenesis inhibitor? -- The HMG (High Mobility Group) proteins in cancer progression -- MTAs in EMT activation and tumour and metastasis promotion -- S100A4 has potential benefits as a therapeutic target -- Notable approaches to cancer immunotherapy. | |
| 650 | 0 | |a Cancer |x Molecular aspects. | |
| 650 | 0 | |a Cancer |x Management. | |
| 650 | 0 | |a Cancer |x Treatment. | |
| 650 | 1 | 2 | |a Neoplasms |x therapy |0 (DNLM)D009369Q000628 |
| 650 | 2 | 2 | |a Molecular Medicine |0 (DNLM)D062346 |
| 650 | 6 | |a Cancer |x Aspect mol�eculaire. |0 (CaQQLa)201-0212614 | |
| 650 | 6 | |a Cancer |0 (CaQQLa)201-0004683 |x Gestion. |0 (CaQQLa)201-0380063 | |
| 650 | 6 | |a Cancer |x Traitement. |0 (CaQQLa)201-0004693 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Clinical Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Diseases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Evidence-Based Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Oncology. |2 bisacsh | |
| 650 | 7 | |a Cancer |x Molecular aspects |2 fast |0 (OCoLC)fst00845397 | |
| 650 | 7 | |a Cancer |x Treatment |2 fast |0 (OCoLC)fst00845538 | |
| 655 | 0 | |a Electronic books. | |
| 655 | 4 | |a Internet Resources. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128128961 |z Texto completo |