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Piperidine-based drug discovery /
Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including mult...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam, Netherlands :
Elsevier,
[2017]
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| Colección: | Heterocyclic drug discovery series.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Synthesis of Piperidin-4-Ones by Dieckmann CondensationSynthesis of Piperidin-4-Ones by Miscellaneous Methods; Nucleophilic Addition Reactions to the Carbonyl Group of Piperidin-4-Ones; Nucleophilic Substitution Reactions Involving [alpha]-Carbon of Piperidin-4-Ones; Piperidin-3-Ones; Piperidin-2-Ones; 4-Cyano-4-Phenylpiperidines; References; 2. 1-Substituted Piperidines; 2.1 Derivatives of 1-Phenyl-3-(Piperidin-1-yl)Propan-1-ol; Trihexyphenidyl (2226); Biperiden (1329); Pridinol (157); Cycrimine (82); 2.2 Derivatives of 1-Phenyl-4-(Piperidin-1-yl)Butan-1-ol; Diphenidol (323); Pirmenol (234).
- Front Cover; Piperidine-Based Drug Discovery; Copyright Page; Contents; 1. Introduction; 1.1 The Scope of the Material Under Consideration; 1.2 General Methods of the Synthesis of Piperidine Compounds; Nucleophilic Substitution Reactions; Intermolecular Michael Reactions; Catalyzed Hydroamination Reactions; Aza-Diels-Alder Reactions; Intramolecular Ene Reactions; Ring-Closing Metathesis Reactions; Synthesis of Piperidin-4-Ones; The Synthesis of 2,2,6,6-Tetramethyl-4-Oxopiperidine; Petrenko-Kritschenko Reaction for the Synthesis of 2,6-Disubstituted Piperidin-4-Ones.
- 2.3 Derivatives of 2-(Piperidin-1-yl)Ethan-1-ol and 3-(Piperidin-1-yl)Propan-1-olCloperastine (199); Benproperine (140); Pipazethate (98); Raloxifene (7685); Flavoxate (452); Piperocaine (266); 2.4 Derivatives of 3-(Piperidin-1-yl)Propane-1,2-Diol and 3-(Piperidin-1-yl)Propane-1,1-Diol; Diperodon (147); Pipoxolan (25); 2.5 Derivatives of 1-Phenyl-3-(Piperidin-1-yl)Propan-1-One; Dyclonine (584); 2.6 Derivatives of 2,2-Diphenyl-4-(Piperidin-1-yl)Butanamide; Fenpiverinium Bromide (83); References; 3. 2-Substituted and 1,2-Disubstituted Piperidines; 3.1 Methylphenidate (11968).
- 3.2 Perhexiline (1216)3.3 Pipradrol (259); 3.4 Mefloquine (5370); 3.5 Mepivacaine (4176); 3.6 Ropivacaine (6847); 3.7 Bupivacaine (21293) and Levobupivacaine (1976); 3.8 Flecainide (3638); 3.9 Encainide (682); 3.10 Thioridazine (6558); 3.11 Rimiterol (219); 3.12 Lobeline (1914); 3.13 Argatroban (2627); 3.14 Ascomycin (752), Pimecrolimus (1645), Tacrolimus (32436), Sirolimus (22468), Everolimus (8972), and Temsirolimus (2859); References; 4. 3-Substituted and 1,3-Disubstituted Piperidines; 4.1 Methixene (92); 4.2 Tipepidine (132); 4.3 Timepidium (83); 4.4 Tiagabine (2008).
- 4.5 Piperidolate (72)4.6 Mepenzolate (137); 4.7 Pipenzolate (109); 4.8 Benidipine (927); 4.9 Paroxetine (12203) and Femoxetine (270); 4.10 Troxipide (110); 4.11 Linagliptin (1133); 4.12 Tofacitinib (1130); References; 5. 4-Substituted and 1,4-Disubstituted Piperidines; 5.1 4-Piperidinols and Their Derivatives; Periciazine (112); Diphenylpyraline (453); Ebastine (990); Bepotastine (236); Lamifiban (257); Eucatropine (90); Propiverine (664); Pentapiperide (22); 5.2 4-Phenylpiperidin-4-ols and Their Derivatives; Haloperidol (41140); Bromperidol (515); Moperone (218); Trifluperidol (613).