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Milestones in immunology : based on collected papers /
'Milestones in Immunology: Based on Collected Papers' contains scientific milestones relating to the history of medicine over the past two centuries. The book highlights the contributions of pioneering scientists whose discoveries have paved the way for researchers working in the field of...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Oxford :
Academic Press, an imprint of Elsevier,
[2017]
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Milestones in Immunology; Copyright Page; Contents; About the Author; Foreword; References; Further Reading; 1 The Contribution of Bruce Glick to the Definition of the Role Played by the Bursa of Fabricius in the Development of the ... ; 1.1 Fabricius ab Aquapendente and the Discovery of the Bursa; 1.2 The Bursa of Fabricius Plays a Major Role in the Development of Antibody-Mediated Immunity; 1.3 Bursectomy do not Abrogate the Antibody Response to Cellular Antigens; 1.4 Immunoglobulin Synthesis Regulation; 1.5 Delineation of the Thymic and Bursal Lymphoid Systems in the Chicken.
- 1.6 Bursa of Fabricius Equivalent in Mammals and Other VertebratesReferences; 2 The Contribution of Robert A. Good and Francis A.P. Miller to the Discovery of the Role of Thymus in Immunity; 2.1 Biographic Notes; 2.2 The Thymus and Its Function; 2.3 The Functional Anatomy of the Human Thymus; 2.4 Studies of the Thymus in the Chick; 2.5 Idiopathic Acquired Agammaglobulinemia Associated With Thymoma; 2.6 The Effects of Neonatally Thymectomy; 2.7 The Restorative Effect of Thymomas or Thymus Grafts on Thymic Function; 2.8 Removal of Either the Thymus or Bursa of Fabricius.
- 2.9 The Importance of a Functional Thymus in HumanReferences; Further Reading; 3 The Discovery of the Blood-Thymus Barrier; 3.1 The Concept of Barrier Between Blood and Tissues; 3.2 Horseradish Peroxidase as a Marker of Vascular Permeability; 3.3 The Blood-Thymus Barrier; 3.4 The Description of the Blood-Thymus Barrier; 3.5 Further Evidence of the Existence of the Barrier, Controversies and Clinical Relevance; References; Further Reading; 4 Max D. Cooper and the Delineation of Two Lymphoid Lineages in the Adaptive Immune System; 4.1 Biographic Notes.
- 4.2 The Role of the Bursa of Fabricius and of the Thymus in the Definition of Two Patterns of Lymphocyte Lineages4.3 The Immunoglobulin Isotype Switching; 4.4 Mammalian "Bursa-Equivalent" Organs and the Role of Liver and Bone Marrow in Lymphopoiesis; 4.5 Clinical Correlates; 4.6 Concluding Remarks; References; 5 Edelman's View on the Discovery of Antibodies; 5.1 Biographic Note; 5.2 The Discovery of the Structure of Immune Globulins; 5.3 The Discovery of L-chain Polypeptide in the Urine of Multiple Myeloma Patients; References.
- 6 From the Discovery of Monoclonal Antibodies to Their Therapeutic Application: An Historical Reappraisal6.1 The Discovery; 6.2 Therapeutic Applications; 6.3 Concluding Remarks; References; 7 Sir Frank Macfarlane Burnet and the Clonal Selection Theory of Antibody Formation; 7.1 Introduction; 7.2 Biographical Note; 7.3 The Instructive Theories of Antibody Production; 7.4 The Selective Theories of Antibody Production; 7.5 The Clonal Selection Theory; 7.6 Evidence Supporting the Theory; 7.7 Concluding Remarks; References; Further Reading.