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Glyceraldehyde-3-phosphate Dehydrogenase Gapdh : the quintessential moonlighting protein in normal cell function and in human disease /
Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press, an imprint of Elsevier,
2017.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Section I. The Role of Moonlighting GAPDH in Normal Cell Function. The role of moonlighting GAPDH in cell proliferation : the dynamic nature of GAPDH expression and subcellular localization
- Moonlighting GAPDH and the transcriptional regulation of gene expression : multiprotein complex formation and mechanisms of nuclear translocation
- The diversity of moonlighting GAPDH function in posttranscriptional RNA regulation : mRNA stability, tRNA processing, and viral pathogenesis
- The role of moonlighting GAPDH in membrane structure and function : membrane fusion and iron metabolism
- The role of moonlighting GAPDH in intracellular membrane trafficking : tubulin regulation and modulation of cytoskeletal structure
- Moonlighting GAPDH and the maintenance of DNA integrity : preservation of genetic information and cancer facilitation
- Moonlighting GAPDH in neuronal structure and function : regulation of ion channels and signal transduction
- Section II. Physiological Stress and GAPDH Functional Diversity. The significance of nitric oxide-modified GAPDH : regulation of apoptosis, cell signaling, and heme metabolism
- GAPDH and hypoxia : mechanisms of cell survival during oxygen deprivation
- Moonlighting GAPDH and ischemia : cellular and molecular effects of oxygen deprivation and reperfusion
- Section II. The Pathology of GAPDH Functional Diversity. GAPDH and tumorigenesis : molecular mechanisms of cancer development and survival
- Moonlighting GAPDH and age-related neurodegenerative disease : diversity of protein interactions and complexity of function
- Functional diversity of GAPDH in infection and immunity : the complexity of "simple" organisms
- Moonlighting GAPDH and diabetes : pleiotropic effects of perturbations in GAPDH structure and function
- Section IV. The Pharmacology of Moonlighting GAPDH
- Section V. The Unique Role of Sperm-Specific GAPDH
- Section VI. Discussion.