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Nuclear receptors in development and disease /
"Nuclear Receptors in Development and Disease, Volume 125, the latest volume in the Current Topics in Developmental Biology series, covers nuclear receptors in development and disease, and includes contributions from an international board of authors. New chapters in this release cover the Evol...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press is an imprint of Elsevier,
2017.
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| Colección: | Current topics in developmental biology ;
v. 125. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- AcknowledgmentsReferences; Chapter Three: Nuclear Receptors in Skeletal Homeostasis; 1. Introduction; 1.1. Bone and Bone Cells; 1.2. Nuclear Receptors; 2. NRs and Bone Homeostasis; 2.1. Estrogen Receptor; 2.1.1. Estrogens and Bone Health; 2.1.2. ER Knockout Models; 2.1.3. Mechanisms; 2.2. Androgen Receptor; 2.3. Glucocorticoid Receptor; 2.4. Peroxisome Proliferator-Activated Receptor; 2.4.1. Peroxisome Proliferator-Activated Receptor [alpha]; 2.4.2. Peroxisome Proliferator-Activated Receptor [delta]/[beta]; 2.4.3. Peroxisome Proliferator-Activated Receptor [gamma]; 2.5. Vitamin D Receptor
- 2.6. Retinoid Acid Receptor and RXR2.7. Estrogen Receptor-Related Receptor; 2.8. NR4A Orphan NRs; 3. Conclusions; Acknowledgments; References; Chapter Four: Estrogen Hormone Biology; 1. Introduction; 2. Cell Mechanisms; 3. Uterine Estrogen Response; 3.1. Genetic Control of Estrogen Responses; 3.2. ER[alpha] Mutations Demonstrate Uterine Mechanisms; 3.3. Tethered Pathway Analysis Using DNA-Binding Deficient ER[alpha] Mutants; 3.4. Analysis of AF-1- and AF-2-Mediated Responses; 3.5. Analysis of Biological Impact of Membrane-Initiated Signaling; 3.6. ER[beta] Does Not Impact Uterine Responses
- 3.7. Importance of ER[alpha] to Uterine Function Informs Mechanisms of Disease4. ER in the Ovary; 4.1. Ovarian Phenotypes of ER[alpha] Mutant Mice; 4.2. Ovary-Specific ER[alpha] Knockouts; 4.3. Ovarian Phenotypes of ER[beta] Mutant Mice; 4.4. Role of ER[beta] Signaling in Granulosa Cells; 4.5. Ovarian Phenotypes of ER[alpha] and ER[beta] Compound Mutant Mice; 4.6. Ovarian Phenotypes in Mice Lacking Estradiol Synthesis; 5. ER in Metabolism; 5.1. Metabolic Phenotype of ER[alpha] Knockout Mice; 5.2. Physiological Role of ER[alpha] Transactivation Domains in Metabolism; 5.3. Phenotype of ER[alpha] DNA-Binding Domain Mutant Mice in Metabolism
- Front cover; Nuclear Receptors in Development and Disease; Copyright; Contents; Contributors; Preface; Chapter One: Evolution of Nuclear Receptors and Ligand Signaling: Toward a Soft Key-Lock Model?; 1. Introduction; 2. The Ligand-Receptor Couple for NRs; 3. NR Diversification During Animal Evolution; 4. Evolution of Ligand Binding; 5. Alternative Ligands; 6. Generalization; References; Chapter Two: The Function and Evolution of Nuclear Receptors in Insect Embryonic Development; 1. Introduction: Nuclear Receptor Structure and Function; 2. Roles of NRs in Drosophila Embryonic Development
- 2.1. Nuclear Receptors and Early Patterning Mechanisms2.2. Functions of NRs During Neurogenesis; 2.3. A Cascade of NR Activity in Response to Ecdysone Mediates Mid-Embryogenesis Morphogenetic Movements and Recalibrates ... ; 2.4. Functions of NRs in Morphogenesis and Maturation of Metabolic Organs; 2.5. Other NR Functions During Organogenesis; 2.6. Future Directions; 3. Functional Analysis of NRs in Nonmodel Insects; 3.1. Insects Are the Most Diverse Group on the Planet; 3.2. Genomic Inventory of NRs Across Insect Species; 3.3. Functional Studies of NRs in Emerging Insect Model Systems