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|a Biometals in neurodegenerative diseases :
|b mechanisms and therapeutics /
|c edited by Anthony R. White, Michael Aschner, Lucio G. Costa, Ashley I. Bush.
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| 260 |
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|a London, United Kingdom :
|b Academic Press is an imprint of Elsevier,
|c 2017.
|
| 300 |
|
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|a 1 online resource
|
| 336 |
|
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|a text
|b txt
|2 rdacontent
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| 337 |
|
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|a computer
|b c
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|a online resource
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0 |
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|a Cover; Title page; Copyright page; Contents; Contributors; Preface; Chapter 1 -- Biometals and Alzheimer's Disease; Introduction; The Role of Copper in AD; The Role of Zinc in AD; The Role of Iron in AD; Therapeutic Targeting of Biometals in AD; Conclusions; References; Chapter 2 -- Copper in Alzheimer's Disease; Introduction; The Physiology of Copper; Copper Absorption and Distribution; Copper in the Liver; Copper's Path From General Circulation to the Brain; The Key Role of Ceruloplasmin; Copper Toxicity; The Role of Copper in Alzheimer's Disease; Genetics of Copper and AD.
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| 505 |
8 |
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|a The AD Copper SubtypeConclusions; References; Chapter 3 -- The Role of Selenium in Neurodegenerative Diseases; Introduction; Selenoproteins and the Selenoproteome; Selenium and Alzheimer's Disease; Parkinson's Disease; Other Neurodegenerative Diseases; Conclusions; References; Chapter 4 -- Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response?; Iron; Hemochromatosis; Discovery; Types; HFE; Structure; Function; Polymorphisms; Macrophages; Macrophage and Iron Metabolism; Macrophage Polarization; Macrophages and HFE; HFE and Neurodegenerative Diseases.
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| 505 |
8 |
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|a Alzheimer's DiseaseAmyotrophic Lateral Sclerosis; Parkinson's Disease; HFE and Cancer; HFE Animal Models; Conclusions; References; Chapter 5 -- Chemical Elements and Oxidative Status in Neuroinflammation; Introduction; Metal-Induced Neurotoxicity and Multiple Sclerosis; Metals and Oxidative Status in Multiple Sclerosis; Metals and Oxidative Status in Clinically Isolated Syndromes; Conclusions; References; Chapter 6 -- Metals and Neuroinflammation; Introduction; Mechanisms by Which Metal Elements Can Incite Immune Activity; Metals as Haptens; Metal Elements with Valence Instability; Copper (Cu).
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| 505 |
8 |
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|a Iron (Fe)Manganese; Metals Attaching to Sulfhydryl Residues; Lead (Pb); Mercury (Hg); Metals Associated with Particulate and Colloidal Materials; Aluminum (Al); Titanium, Silver and Gold (Ti, Ag, Au); Metals Which Lead to Oxidative Stress and Inflammation by Means that are not yet Understood; The Relation Between Reactive Oxygen and Nitrogen Species and Inflammation; Conclusions; References; Chapter 7 -- Metals and Prions: Twenty Years of Mining the Awe; Prion Diseases; Prion Protein; Prion Protein Function; Copper and PrP; Zinc and PrP; Iron and PrP; Manganese and PrP; Metals in Prion Disease.
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| 505 |
8 |
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|a Chelation Therapy and Prion DiseaseConclusions; References; Chapter 8 -- Manganese and Neurodegeneration; Background; Mn Essentiality and Metabolic Functions; Mn Biokinetics and Homeostatic Control; Routes and Sources of Mn Exposure; Absorption of Airborne Mn; Parenteral Exposure to Mn; Oral Absorption of Mn From Food and Water; Mn Biodistribution and Elimination; Biokinetics of Mn in Brain; Mn Transport Into Brain; Regional Delivery of Mn in the Brain; Mn Elimination From Brain Compartment; Subcellular Distribution of Mn in Brain; Homeostatic Control of Mn.
|
| 500 |
|
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|a Includes index.
|
| 588 |
0 |
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|a Print version record.
|
| 504 |
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|a Includes bibliographical references and index.
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| 650 |
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0 |
|a Metals in the body.
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| 650 |
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0 |
|a Nervous system
|x Degeneration.
|
| 650 |
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0 |
|a Metals
|x Physiological effect.
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| 650 |
1 |
2 |
|a Neurodegenerative Diseases
|x physiopathology
|0 (DNLM)D019636Q000503
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| 650 |
2 |
2 |
|a Nervous System
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|0 (DNLM)D009420Q000737
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| 650 |
2 |
2 |
|a Trace Elements
|x pharmacology
|0 (DNLM)D014131Q000494
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| 650 |
|
6 |
|a M�etaux dans l'organisme.
|0 (CaQQLa)201-0033639
|
| 650 |
|
6 |
|a M�etaux
|x Effets physiologiques.
|0 (CaQQLa)201-0047733
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| 650 |
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|a MEDICAL
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|2 bisacsh
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| 650 |
|
7 |
|a SCIENCE
|x Life Sciences
|x Human Anatomy & Physiology.
|2 bisacsh
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| 650 |
|
7 |
|a Metals in the body
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| 650 |
|
7 |
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|
| 650 |
|
7 |
|a Nervous system
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|0 (OCoLC)fst01036090
|
| 655 |
|
0 |
|a Electronic books.
|
| 655 |
|
4 |
|a Internet Resources.
|
| 776 |
0 |
8 |
|i Print version:
|t Biometals in neurodegenerative diseases.
|d London, United Kingdom : Academic Press is an imprint of Elsevier, 2017
|z 0128045620
|z 9780128045626
|w (OCoLC)964294016
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128045626
|z Texto completo
|
