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20231120112227.0 |
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170503s2017 enk ob 001 0 eng d |
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|a 2017302008
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|2 23
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| 100 |
1 |
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|a Blanco, Ignacio,
|e author.
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| 245 |
1 |
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|a Blanco's overview of alpha-1 antitrypsin deficiency :
|b history, biology, pathophysiology, related diseases, diagnosis and treatment /
|c Ignacio Blanco.
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| 246 |
3 |
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|a Overview of alpha-1 antitrypsin deficiency
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| 264 |
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1 |
|a London, United Kingdom :
|b Academic Press is an imprint of Elsevier,
|c 2017.
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| 300 |
|
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|a 1 online resource
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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0 |
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|a Cover; Title page; Copyright page; Dedication; Contents; Preface; Acknowledgments; Chapter 1 -- Alpha-1 Antitrypsin Deficiency: Introduction and History; 1.1 -- Introduction; 1.2 -- History of the alpha-1 antitrypsin deficiency; References; Chapter 2 -- Serpins and Serpinopathies; 2.1 -- Introduction; 2.2 -- The serpin superfamily; 2.2.1 -- Classification and Nomenclature; 2.2.2 -- Structure and Inhibitory Mechanisms; 2.2.3 -- Polymerization; 2.2.4 -- Serpinopathies; 2.2.4.1 -- Alpha-1 Antitrypsin Deficiency; 2.2.4.2 -- Alpha-1 Antichymotrypsin Deficiency; 2.2.4.3 -- Antithrombin Deficiency
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|a 2.2.4.4 -- C1 Inhibitor Deficiency2.2.4.5 -- Neuroserpin Deficiency; 2.2.4.6 -- Transcortin Deficiency; 2.2.4.7 -- Thyroxine-Binding Globulin Deficiency; References; Chapter 3 -- Alpha-1 Antitrypsin Biology; 3.1 -- Structure; 3.2 -- Synthesis and secretion; 3.3 -- Substrate; 3.4 -- Properties; 3.4.1 -- Inhibition of Extracellular Serine Proteases; 3.4.2 -- Inhibition of Transmembrane and Intracellular Proteases; 3.4.3 -- Nonprotease-Inhibitory Antiinflammatory and Immunomodulatory Properties; 3.4.4 -- Antimicrobial Properties; 3.4.5 -- Protection and Repair of Damaged Tissues by Inflammation; References
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|a Chapter 4 -- Alpha-1 Antitrypsin Gene, Genetic Heritage, Phenotypes, and Genotypes4.1 -- The alpha-1 antitrypsin gene; 4.1.1 -- Locus; 4.1.2 -- Expression Regulation; 4.1.3 -- Transcription Stimuli; 4.1.4 -- AAT Transcription; 4.1.5 -- Intracellular Mechanisms of Protein Folding and Secretion; 4.2 -- The "protease inhibitor" system; 4.3 -- Genetic inheritance; 4.4 -- Nomenclature; References; Chapter 5 -- Alpha-1 Antitrypsin Deficiency: Liver Pathophysiology; 5.1 -- Introduction; 5.2 -- The Z and S mutations; 5.3 -- Pathophysiology; 5.4 -- Clinical expression; References
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|a Chapter 6 -- Alpha-1 Antitrypsin Deficiency: Lung Pathophysiology6.1 -- Introduction; 6.2 -- Physiopathological mechanisms of alpha-1 antitrypsin deficiency-related COPD; 6.2.1 -- Alpha-1 Antitrypsin Genotypes Related to COPD Development; 6.2.2 -- Mechanisms; 6.2.2.1 -- Protease-Mediated Lung Disease; 6.2.2.2 -- Oxidant-to-Antioxidant Imbalance; 6.2.2.3 -- Tumor Necrosis Factor-Related Impaired Neutrophil Activity; 6.2.2.4 -- Autoimmunity-Mediated COPD; 6.2.2.5 -- Accumulation of Z Protein Polymers in the Airways; 6.3 -- Clinical expression; References; Chapter 7 -- Genetic Epidemiology
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|a 7.1 -- Introduction7.2 -- Pi*Z frequency and prevalence in EuropE; 7.2.1 -- Origin and Spread of the Z Mutation; 7.3 -- Pi*Z frequency in the world; 7.4 -- Number and distribution of Pi*ZZ genotypes in Europe; 7.5 -- Number and distribution of Pi*ZZ genotypes in America; 7.6 -- Number and distribution of Pi*ZZ genotypes in Africa, Asia, Australia, and New Zealand; 7.7 -- Pi*S frequency distribution in the world; 7.8 -- Number and distribution of Pi*SZ genotypes in the world; References; Chapter 8 -- Laboratory Diagnosis; 8.1 -- Introduction
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|a 8.2 -- Clinical situations in which alpha-1 antitrypsin deficiency should be suspected
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|a Online resource; title from PDF title page (ScienceDirect, viewed May 16, 2017).
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|a Includes bibliographical references and index.
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| 650 |
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|a Alpha 1-antitrypsin deficiency.
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| 650 |
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|a Alpha 1-antitrypsin deficiency
|x Diagnosis.
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| 650 |
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|a Alpha 1-antitrypsin deficiency
|x Treatment.
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| 650 |
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2 |
|a alpha 1-Antitrypsin Deficiency
|0 (DNLM)D019896
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| 650 |
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|a alpha 1-Antitrypsin Deficiency
|x diagnosis
|0 (DNLM)D019896Q000175
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| 650 |
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|a alpha 1-Antitrypsin Deficiency
|x therapy
|0 (DNLM)D019896Q000628
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| 650 |
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|a Carence en alpha-1-antitrypsine.
|0 (CaQQLa)201-0277949
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| 650 |
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|a Carence en alpha-1-antitrypsine
|0 (CaQQLa)201-0277949
|x Traitement.
|0 (CaQQLa)201-0377521
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| 650 |
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7 |
|a HEALTH & FITNESS
|x Diseases
|x General.
|2 bisacsh
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| 650 |
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|a MEDICAL
|x Clinical Medicine.
|2 bisacsh
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| 650 |
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7 |
|a MEDICAL
|x Diseases.
|2 bisacsh
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| 650 |
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|a MEDICAL
|x Evidence-Based Medicine.
|2 bisacsh
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| 650 |
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|a MEDICAL
|x Internal Medicine.
|2 bisacsh
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| 650 |
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|a Alpha 1-antitrypsin deficiency
|2 fast
|0 (OCoLC)fst00805916
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| 655 |
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|a Electronic books.
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| 655 |
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4 |
|a Internet Resources.
|
| 776 |
0 |
8 |
|i Print version:
|a Blanco, Ignacio.
|t Blanco's overview of alpha-1 antitrypsin deficiency.
|d London, United Kingdom : Academic Press is an imprint of Elsevier, 2017
|z 012809530X
|z 9780128095300
|w (OCoLC)962896276
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128095300
|z Texto completo
|
