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A roadmap for curing cancer, Alzheimer's, and cardiovascular disease /
Cancer, dementia, and cardiovascular disease are responsible for almost two million deaths each year in the United States alone and represent the largest immediate threat to humanity. Over the last century, we have made spectacular advances that have transformed our society - splitting the atom, spa...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
[2017]
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Part A. The reasons for failure
- The medical R & D fiasco
- Academia is marching to the wrong drummer
- Mavericks versus the establishment
- The strangled unincentivized drug industry
- The FDA roadblock to cures
- The liability barrier
- Part B. Towards solutions
- Cleaning up the academic research quagmire
- Reforming the FDA
- Enabling the drug industry
- Patent and liability reform
- The public will make it happen.
- Front Cover; A Roadmap for Curing Cancer, Alzheimer's, and Cardiovascular Disease; A Roadmap for CuringCancer, Alzheimer's, and CardiovascularDisease; Copyright; Dedication ; Contents; Preface; Acknowledgments; A
- The Reasons for Failure; 1
- The Medical R & D Fiasco; THE MOST SERIOUS HUMANITARIAN CRISIS; THE MAGNITUDE OF THE PROBLEM; MY JOURNEY THROUGH THE QUAGMIRE; WHERE TO BEGIN; CANCER: FIFTY YEARS OF THE SAME TOXIC DRUGS; NEURODEGENERATIVE DISEASE: CRIMINAL NEGLIGENCE; CARDIOVASCULAR DISEASE: TREATING THE SYMPTOMS; TIME TO GET SERIOUS; REFERENCES
- 2
- Academia Is Marching to the Wrong DrummerSCIENCE FOR ITS OWN SAKE; CHAOTIC POOR-QUALITY SCIENCE; UNIVERSITIES: WHERE IS THE ACCOUNTABILITY?; TECHNOLOGY TRANSFER, WHY BOTHER?; THE COLLABORATION MYTH; THOUGHT LEADERS: BLESSING OR CURSE?; THE NATIONAL INSTITUTES OF HEALTH: WHERE IS THE BEEF?; STRATEGY, ACCOUNTABILITY, AND URGENCY: THE MISSING LINKS; REFERENCES; 3
- Mavericks Versus the Establishment; MEDICAL RESEARCH 101; ESTABLISHED SCIENCE IS BEING WASTED; MAVERICK SCIENCE, OUR BEST HOPE?; OLD DRUGS FOR NEW USES AND MAVERICKS; GETTING PHYSICIANS BACK IN THE GAME
- NATURAL AGENTS ARE BEING OVERLOOKEDCHARITIES: AN INSULT TO THE CURE QUEST; THE BOTTOM LINE ON THE RESEARCH ENTERPRISE; REFERENCES; 4
- The Strangled Unincentivized Drug Industry; BIOTECHNOLOGY VERSUS PHARMACEUTICALS, MACRO VERSUS MICRO; BIOLOGICS: GREAT TARGETS BUT TERRIBLE DRUGS; BIOLOGICALS: SUPER EXPENSE FOR MARGINAL BENEFIT; GENE THERAPY AND STEM CELL THERAPY: HYPE VERSUS SUBSTANCE?; THE BIOTECHNOLOGY REPORT CARD; START-UP COMPANIES AND WHY THEY FAIL; VENTURE CAPITAL: SELLING SCIENCE FOR PROFIT; PHARMACEUTICALS: WHERE IS THE BEEF?; CORPORATE PARTNERING, OIL, AND WATER; REFERENCES
- 5
- The FDA Roadblock to CuresEVOLUTION OF A MONSTER; THE ROCKY ROAD TO DRUG APPROVAL; CLINICAL TRIALS: A VERY INEXACT SCIENCE; PHASE III: THE MOTHER OF ALL CLINICAL TRIALS; MUST WE BE SO TIMID FOR ALL DRUGS?; TERMINAL DISEASE PATIENTS CONDEMNED TO DEATH; THE MISTAKE THAT CREATED THE MONSTER; SURGERY, AN EXAMPLE OF WHAT FEWER REGULATIONS CAN PRODUCE; REGULATION AND THE PATIENT-PHYSICIAN RELATIONSHIP; REFERENCES; 6
- The Liability Barrier; EVERYONE RESPONDS TO DRUGS DIFFERENTLY; WHERE DOES LIABILITY BEGIN?; MEDICAL CLASS ACTION LAWSUITS: A LITIGATOR'S DREAM; SHOULD WE TRUST THE DRUG COMPANIES?
- MALPRACTICE MADNESS WHO WINS?; THE RISK-BENEFIT CONUNDRUM; LIABILITY FOR FAILED CLINICAL TRIALS; REFERENCES; B
- Towards Solutions; 7
- Cleaning Up the Academic Research Quagmire; REBUILDING THE NATIONAL INSTITUTES OF HEALTH: NASA FOR CURES; WHAT TO DO WITH ACADEMIA AND INDIRECT COSTS?; CHARITIES: YOU HAVE TO BE KIDDING!; QUALITY CONTROL IN RESEARCH; INJECTING STRATEGY AND MANAGEMENT INTO MEDICAL RESEARCH; FEWER THOUGHT LEADERS AND MORE MAVERICKS; THE PUBLIC RIP OFF; REFERENCES; 8
- Reforming the FDA; THE EVOLUTION OF DRUG REGULATION; RETHINKING THE FDA; SOME COMMON FDA HORROR STORIES