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Validamycin and its derivatives : discovery, chemical synthesis, and biological activity /

Validamycin and its derivatives: discovery, chemical synthesis and biological activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds. Beginning with an introduction to validamycin, the book then outlines the key el...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Chen, Xiaolong (Autor), Lu, Yuele (Autor), Fan, Yongxian (Autor), Shen, Yinchu (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam, Netherlands ; Oxford, United Kingdom : Elsevier, 2017.
Temas:
Acceso en línea:Texto completo

MARC

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245 1 0 |a Validamycin and its derivatives :  |b discovery, chemical synthesis, and biological activity /  |c Xiaolong Chen, Yuele Lu, Yongxian Fan and Yinchu Shen, Institute of Fermentation Engineering, Zhejiang University of Technology, Hangzhou, PR China. 
264 1 |a Amsterdam, Netherlands ;  |a Oxford, United Kingdom :  |b Elsevier,  |c 2017. 
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520 |a Validamycin and its derivatives: discovery, chemical synthesis and biological activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds. Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production. Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored. Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications. Offers complete coverage of validamycin chemistry from a highly experienced team of authors. 
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