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SCIDIR_ocn978351002 |
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170324s2017 enk o 001 0 eng d |
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|a Biology and engineering of stem cell niches /
|c edited by Ajaykumar Vishwakarma, Jeffrey M. Karp.
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1 |
|a London, United Kingdom :
|b Academic Press is an imprint of Elsevier,
|c 2017.
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|a 1 online resource
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|a Vendor-supplied metadata.
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0 |
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|6 880-01
|a Front Cover; BIOLOGY AND ENGINEERING OF STEM CELL NICHES; BIOLOGY AND ENGINEERING OF STEM CELL NICHES; Copyright; Contents; List of Contributors; Foreword; 1 -- Biology of Stem Cell Niches and Molecular Mechanisms; 1 -- The Need to Study, Mimic, and Target Stem Cell Niches; 1. INTRODUCTION; 1.1 The Stem Cell Niche in Health and Disease; 1.2 Components of Stem Cell Niche; 2. BIOLOGY OF THE STEM CELL NICHE; 2.1 Behavior of Stem Cells: Hierarchical Versus Stochastic Model; 2.2 Embryonic and Adult Stem Cell Niches; 3. BIOCHEMICAL AND BIOPHYSICAL REGULATION OF STEM CELL BEHAVIOR.
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|a 3.1 Extracellular Matrix and Biochemical Cues3.2 Soluble Growth Factors and Ligands; 3.3 Physical Cues and Matrix Mechanics; 3.4 Oxygen and Metabolism; 3.5 Immune Cells, Inflammation, and Immunomodulation; 4. MIMICKING THE STEM CELL NICHE: BIOENGINEERING TOOLS AND TECHNIQUES; 5. BIOENGINEERING SPECIALIZED ARTIFICIAL STEM CELL NICHES FOR CLINICAL THERAPIES; References; 2 -- Harnessing the Biology of Stem Cells' Niche; 1. INTRODUCTION; 2. COMPONENTS OF THE STEM CELL NICHE; 2.1 Cellular Components; 2.2 Noncellular Components; 3. INTEGRATIVE NETWORKS REGULATING THE NICHE.
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| 505 |
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|a 4. DISTINCT NICHES FOR DIFFERENT STAGES OF DIFFERENTIATION5. NEOPLASTIC TRANSFORMATION AND DISTURBANCE OF THE TISSUE ECOSYSTEM; 6. CONCLUSION; ABBREVIATIONS AND ACRONYMS; Glossary; References; 3 -- Pluripotent Stem Cell Microenvironment; 1. INTRODUCTION; 2. PLURIPOTENT CELL MICROENVIRONMENT IN THE EARLY MAMMALIAN EMBRYO; 2.1 Lineage Specification in the Preimplantation Embryo; 2.2 Role of Extraembryonic Cells in Development of the Pluripotent Cells; 2.2.1 Interactions Between Inner and Outer Blastomeres During the ICM Versus TE Specification and Associated Signals.
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| 505 |
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|a 2.2.2 Cellular Interplay Between the PrE and the Epiblast3. MICROENVIRONMENT OF PLURIPOTENT STEM CELLS IN VITRO; 3.1 Derivation of Embryonic Stem Cells; 3.2 Cellular Heterogeneity in Mouse ESC Cultures; 3.3 Epigenetic Mechanisms Underlying Metastable States of Mouse ESCs; 3.4 Heterogeneity of Human ESC Culture; 3.5 Functional and Epigenetic Distinctions Between Human ESC Subfractions; 3.6 Regulatory Niche in Human ESC Culture; 4. CONCLUSION; ABBREVIATIONS AND ACRONYMS; Glossary; Acknowledgment; References; 4 -- Regulation of Hematopoietic Stem Cell Dynamics by Molecular Niche Signaling.
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| 500 |
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|a Includes index.
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| 504 |
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|a Includes bibliographical references and index.
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| 650 |
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0 |
|a Stem cells.
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| 650 |
1 |
2 |
|a Stem Cell Niche
|0 (DNLM)D055153
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| 650 |
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2 |
|a Stem Cells
|0 (DNLM)D013234
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| 650 |
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6 |
|a Cellules souches.
|0 (CaQQLa)201-0058821
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| 650 |
|
7 |
|a SCIENCE
|x Life Sciences
|x Cell Biology.
|2 bisacsh
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| 650 |
|
7 |
|a Stem cells
|2 fast
|0 (OCoLC)fst01132975
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| 655 |
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0 |
|a Electronic books.
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| 655 |
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4 |
|a Internet Resources.
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| 700 |
1 |
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|a Vishwakarma, Ajaykumar,
|e editor.
|
| 700 |
1 |
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|a Karp, Jeffrey,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|t Biology and engineering of stem cell niches.
|d London, United Kingdom : Academic Press is an imprint of Elsevier, 2017
|z 0128027347
|z 9780128027349
|w (OCoLC)960895662
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128027349
|z Texto completo
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| 880 |
8 |
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|6 505-01/(S
|a 1. INTRODUCTION2. ORGANIZATION OF HEMATOPOIETIC STEM CELL NICHE IN THE BONE MARROW; 3. NICHE SIGNALING; 3.1 Transformation Growth Factor Beta and Bone Morphogenic Pathway Signaling; 3.1.1 Transforming Growth Factor-β Signaling; 3.1.2 BMP Signaling; 3.2 Wnt Signaling; 3.2.1 Canonical Wnt Signaling; 3.2.2 Noncanonical Wnt Signaling; 3.3 Growth Factors, Cytokines, and Chemokines; 3.3.1 c-Kit-Stem Cell Factor Signaling; 3.3.2 CXCL12-Cxcr4/Stromal Cell-Derived Factor 1 Signaling; 3.3.3 Angiopoietin1; 3.3.4 Osteopontin and Thrombopoietin; 3.4 Notch Signaling and Hedgehog Signaling.
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