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|a (OCoLC)973396830
|z (OCoLC)973509502
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|z (OCoLC)973907572
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|a 612.6/7
|2 23
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| 245 |
0 |
0 |
|a Molecular biology of aging /
|c edited by P. Hemachandra Reddy.
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| 264 |
|
1 |
|a Cambridge, MA :
|b Academic Press,
|c 2017.
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| 300 |
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|a 1 online resource
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| 336 |
|
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Progress in molecular biology and translational science ;
|v volume 146
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| 504 |
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|a Includes bibliographical references and index.
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0 |
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|a Online resource, title from PDF title page (EBSCO, viewed March 1, 2017).
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0 |
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|a Front Cover; Molecular Biology of Aging; Copyright; Contents; In Memoriam; Contributors; Preface; Chapter One: Clinical Aspects of Glucose Metabolism and Chronic Disease; 1. Introduction; 2. Diabetes Mellitus; 3. Cardiovascular Disease; 4. Chronic Kidney Disease; 5. Sarcopenia; 6. The Frailty Syndrome; 7. Dementia; 8. Exercise and Brain Metabolism; 9. Pharmacological Treatments for Dementia; 10. Reducing Chronic Disease Burden; References; Chapter Two: Therapeutic Strategies for Mitochondrial Dysfunction and Oxidative Stress in Age-Related Metabolic Disorders; 1. Introduction
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| 505 |
8 |
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|a 2. Global Prevalence of Metabolic Disorders3. Structure and Functions of Mitochondria; 3.1. Mitochondrial Dynamics; 3.2. Mitochondrial Biogenesis; 4. Mitochondrial Dysfunction in Age-Related Metabolic Disorders; 4.1. Type 2 Diabetes Mellitus; 4.2. Obesity; 4.3. Cardiovascular Diseases; 4.4. Stroke; 5. Strategies Directed to Target Mitochondrial Dysfunction; 5.1. Lifestyle Interventions; 5.1.1. Exercise; 5.1.2. Dietary Modifications; 5.2. Pharmacological Interventions; 5.2.1. Mitochondria-Targeted Antioxidants; 5.2.2. Sirtuins; 6. Concluding Remarks; Acknowledgments; References
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| 505 |
8 |
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|a Chapter Three: MicroRNAs as Peripheral Biomarkers in Aging and Age-Related Diseases1. Introduction; 2. Circulatory miRNAs; 3. miRNAs Secretion in Circulatory Biofluids; 4. Circulatory miRNAs as Biomarkers in Aging and Age-Associated Diseases; 4.1. Aging; 4.2. Cardiovascular Disease; 4.3. Cancer; 4.3.1. Aging and Cancer; 4.3.2. Prostate Cancer; 4.3.3. Lung Cancer; 4.3.4. Breast Cancer; 4.3.5. Colorectal Cancer; 4.4. Arthritis; 4.5. Cataract; 4.6. Osteoporosis; 4.7. Diabetes/Obesity; 4.8. Hypertension; 4.9. Neurodegenerative Diseases; 4.9.1. Dementia; 4.9.2. Alzheimer�s Disease
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| 505 |
8 |
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|a 4.9.2.1. Circulatory miRNAs in Whole Blood4.9.2.2. Blood Mononuclear Cells as a Source of miRNAs; 4.9.2.3. Serum as Sources of Circulatory miRNAs; 4.9.2.4. Serum Exosomal miRNAs; 4.9.2.5. Plasma as Sources of Circulatory miRNAs; 4.9.2.6. Plasma Exosomal miRNAs; 4.9.2.7. CSF and Extracellular Fluid Circulatory miRNAs; 4.9.3. Huntington�s Disease; 4.9.4. Parkinson�s Disease; 4.9.5. Amyotrophic Lateral Sclerosis; 5. Concluding Remarks; Acknowledgments; References; Chapter Four: Molecular Links and Biomarkers of Stroke, Vascular Dementia, and Alzheimer�s Disease; 1. Introduction; 1.1. Stroke
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| 505 |
8 |
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|a 1.2. Dementia1.2.1. Vascular Dementia; 1.2.2. Alzheimer�s Disease; 2. Risk Factors for IS, VaD, and AD; 3. Molecular Links and Pathways; 4. Molecular Biomarkers; 4.1. Protein Biomarkers in Stroke, VaD, and AD; 4.2. miRNAs as Peripheral Biomarkers in Stroke, VaD, and AD; 4.2.1. miRNA Profile and Function in Human Samples; 4.2.2. MiRNA Profile and Function in Animal and Postmortem Brain; 5. Concluding Remarks; Acknowledgments; References; Chapter Five: MicroRNAs, Aging, Cellular Senescence, and Alzheimer�s Disease; 1. Introduction; 2. Biogenesis and Regulation of miRNAs
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| 650 |
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0 |
|a Aging
|x Molecular aspects.
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| 650 |
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0 |
|a Aging.
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| 650 |
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2 |
|a Aging
|0 (DNLM)D000375
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| 650 |
|
6 |
|a Vieillissement
|x Aspect mol�eculaire.
|0 (CaQQLa)201-0203052
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| 650 |
|
6 |
|a Vieillissement.
|0 (CaQQLa)201-0020292
|
| 650 |
|
7 |
|a MEDICAL
|x Physiology.
|2 bisacsh
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| 650 |
|
7 |
|a SCIENCE
|x Life Sciences
|x Human Anatomy & Physiology.
|2 bisacsh
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| 650 |
|
7 |
|a Aging
|2 fast
|0 (OCoLC)fst00800293
|
| 650 |
|
7 |
|a Aging
|x Molecular aspects
|2 fast
|0 (OCoLC)fst00800318
|
| 700 |
1 |
|
|a Reddy, P. Hemachandra,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|t Molecular biology of aging.
|d Cambridge, MA : Academic Press, 2017
|z 0128115327
|z 9780128115329
|w (OCoLC)959875085
|
| 830 |
|
0 |
|a Progress in molecular biology and translational science ;
|v v. 146.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/18771173/146
|z Texto completo
|
