Tabla de Contenidos:
  • Cover; Title page; Copyright page; Contents; List of Contributors; Foreword; Preface; Chapter 1
  • Anatomy and Physiology of Normal Sleep; Introduction; Initial Discoveries of Sleep Circuitry; Neuroanatomy and Neurotransmitters; Wake-Promoting Neurotransmitter Systems; Acetylcholine (ACh); Norepinephrine (NE); Dopamine (DA); Histamine (His); Serotonin (5-HT); Hypocretin/Orexin (HCRT); Sleep-Promoting Neurotransmitter and Signaling Systems; Gamma-Aminobutyric Acid (GABA); Acetylcholine (ACh); Melanin-Concentrating Hormone (MCH); Somnogens; Adenosine/Adenosine triphosphate (ATP); Cytokines
  • Prostaglandin D2 (PGD2)Sleep-wake Circuitry; Sustaining Wakefulness; Turning Off the Arousal System; Transitioning to REM; Circadian and Homeostatic Regulation of Sleep; Conclusions; References; Chapter 2
  • Anatomy and Physiology of the Circadian System; Biological Rhythms at the Origin of the Circadian Timing System; Endogenous Circadian Rhythms; The Circadian Timing System; The Central Oscillator; Genetics of the Clockwork in Mammals; Peripheral Oscillators; The Photic Input of the Circadian Timing System in Mammals; Circadian and Nonimage Forming Photoreception
  • Photoreceptors' Contribution to Nonimage Forming Responses to LightOutputs of the Central Clock; Anatomical Projections of the SCN; Some of the Functions Under the Control of the SCN; Locomotor Activity; Heart Rate; Temperature; Sleep; The Corticosteroid System; Cognitive Performance and Alertness; Melatonin Secretion; Circadian Characteristics of Melatonin; Entrainment of the Circadian Timing System; Photo-entrainment; Phase Sensitivity of the Circadian Timing System; Irradiance Sensitivity of the Circadian Timing System; Duration and Pattern Sensitivity of the Circadian Timing System
  • Spectral Sensitivity of the Circadian Timing SystemNonphotic Zeitgebers; Exogenous Melatonin as a Zeitgeber; ConclusionS; References; Chapter 3
  • The Functions of Sleep and the Effects of Sleep Deprivation; Introduction; Sleep and Stress; Regulation of Appetite; GH, PRL, TSH, GnRH, and Testosterone; Mood, Emotional Stability and Reward Circuits; Emotional Maturation; Dreaming; Regulation of Pain; Cognitive Performance and the Effects of Sleep Deprivation; Accidents and Safety in Acute and Chronic Sleep Deprivation; Memory; Insight and Creativity, Gist Memory; Immune Function; Conclusions