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Neuroprotection in Alzheimer's disease /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom :
Academic Press,
2017.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover; Title page; Copyright Page; Dedication; Contents; List of Contributors; Acknowledgments; Chapter 1
- Introduction; Chapter 2
- Neural Regeneration as a Disease-Modifying Therapeutic Strategy for Alzheimer's Disease; Introduction; Global health care burden of Alzheimer's disease: epidemiological data; Etiopathogenesis of Alzheimer's disease: what do we know?; Therapeutic approaches to Alzheimer's disease: the promises, the failures, and the future; Neural regeneration-based therapeutic approach for AD: the rationale, the promise, and the progress.
- Neurotrophic factor small-molecule mimetics for Alzheimer's diseaseEnhancement of neurogenesis and memory by CNTF small-molecule mimetics; CNTF-derived neurogenic/neurotrophic compound, P021, can exert a disease-modifying effect in a transgenic mouse model of AD; Summary and conclusions; References; Chapter 3
- Animal Models of Alzheimer's Disease; Introduction; The genetics of Alzheimer's disease; Transgenic models of amyloidogenesis; Amyloid precursor protein transgenic mice; PDAPP transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Tg2576 transgenic mice; Histopathology.
- BehaviorSynaptic Plasticity; APP23 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; J20 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; APP knock-in transgenic mice; Histopathology; Behavior; Synaptic Plasticity; APP/PS1 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; 5xFAD transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Tau transgenic mice; Tau tg mice under tau promoter; Histopathology; Behavior; Synaptic Plasticity; 3xTg transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Animal models for late onset of AD.
- ApoE Transgenic MiceApoE Knock-Out Transgenic Mice; ApoE2/ApoE3/ApoE4 Knock-In Transgenic Mice; GFAP-ApoE4/ApoE Knock-Out Transgenic Mice; ApoE/APP Transgenic Mice; Nonmouse models; Studies in nematodes; Studies in fruit flies; Nontransgenic models for the study of AD; How to choose the right model?; Summary; Acknowledgment; References; Chapter 4
- Mechanisms of Neuronal Microtubule Loss in Alzheimer's Disease; Introduction; Studies on Alzheimer's brain and animal models; Are microtubules destabilized in the Alzheimer's brain?; Mechanisms of microtubule loss in the Alzheimer's brain.
- Strategies for treatmentAcknowledgments; References; Chapter 5
- Tau-Centric Therapies for Treating Alzheimer's Disease; Introduction; Six Tau Isoforms-Many Tau Functions; Mechanisms of Tau Toxicity: Phosphorylation, Microtubule Destabilization, and Aggregation; Tau-centric therapeutic strategy 1: targeting tau phosphorylation; Tau Phosphorylation in Physiological and Pathological States; Mechanisms for Stimulating Tau Phosphorylation; Consequences of Phosphorylation; Therapeutic Strategies to Inhibit Tau Phosphorylation; Current State of Affairs.