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Molecular diagnostics /

"Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Patrinos, George P. (Editor ), Ansorge, Wilhelm, 1944- (Editor ), Danielson, Phillip B. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam ; Boston : Academic Press is an imprint of Elsevier, [2016]
Edición:Third edition.
Temas:
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; Molecular Diagnostics; Molecular Diagnostics; Copyright; Contents; List of Contributors; Preface, Third Edition; 1
  • Molecular Diagnostics: Past, Present, and Future; 1.1 INTRODUCTION; 1.2 HISTORY OF MOLECULAR DIAGNOSTICS: INVENTING THE WHEEL; 1.3 THE POST-POLYMERASE CHAIN REACTION REVOLUTION; 1.4 MOLECULAR DIAGNOSTICS IN THE POST-GENOMIC ERA; 1.5 FUTURE PERSPECTIVES: WHAT LIES BEYOND; 1.5.1 Commercializing Molecular Diagnostics; 1.5.2 Personalized Medicine; 1.5.3 Personal Genomics; 1.6 CONCLUSIONS; REFERENCES; 2
  • Describing DNA Variants (Mutation Nomenclature); 2.1 INTRODUCTION.
  • 2.2 HISTORY2.3 AUTHORIZATION; 2.4 DEFINITIONS; 2.4.1 Principles; 2.4.2 Reference Sequences; 2.4.3 Locus Reference Genomic Sequence; 2.4.4 Numbering Residues; 2.4.5 Coding Residues; 2.5 VARIANT DESCRIPTIONS; 2.5.1 Substitutions; 2.5.2 Deletions; 2.5.3 Duplications; 2.5.4 Insertions; 2.5.5 Indels (Deletion/Insertions); 2.5.6 Inversions; 2.5.7 Conversions; 2.5.8 Translocations; 2.5.9 Variability in Repeated Sequences; 2.5.10 Alleles; 2.5.11 RNA; 2.5.12 Protein; 2.5.12.1 Nonsense Variants; 2.5.12.2 Frame Shifts; 2.5.12.3 Extensions; 2.6 MUTALYZER; 2.7 CONCLUDING REMARKS; ACKNOWLEDGMENTS.
  • 4.1 HISTORY OF THE POLYMERASE CHAIN REACTION4.2 PRINCIPLE OF REAL-TIME POLYMERASE CHAIN REACTION; 4.2.1 Quantitative Polymerase Chain Reaction Using Hydrolysis Probes; 4.2.2 Quantitative Polymerase Chain Reaction Using DNA Intercalating Dyes; 4.2.3 Quantitative Polymerase Chain Reaction Using Hybridization Probes; 4.2.4 Quantitative Polymerase Chain Reaction Using Primer Probes; 4.2.5 Real-Time Polymerase Chain Reaction Using Modified Nucleic Acids; 4.3 REAL-TIME THERMAL CYCLERS; 4.4 HOW DATA ARE OBTAINED; 4.5 HOW DATA ARE QUANTIFIED; 4.5.1 Standard Curve Method.
  • 4.5.2 Comparative Threshold Cycle Method4.5.3 Pfaffl Method; 4.6 MULTIPLEX QUANTITATIVE POLYMERASE CHAIN REACTION; 4.7 APPLICATIONS OF QUANTITATIVE POLYMERASE CHAIN REACTION AND REVERSE TRANSCRIPTASE-QUANTITATIVE POLYMERASE CHAIN REACTION; 4.7.1 Clinical Microbiology; 4.7.2 Food and Industrial Microbiology; 4.7.3 Clinical Oncology; 4.7.3.1 Minimal Residual Disease; 4.7.3.2 Single Nucleotide Polymorphisms; 4.7.3.3 Chromosomal Translocations; 4.7.4 Gene Therapy; 4.7.5 Validation of ��-Omics'' Related Technologies; 4.7.6 Forensic Genetics.