Micro- and nanotechnology in vaccine development /

This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Skwarczynski, Mariusz (Editor ), Toth, Istvan (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Elsevier, [2017]
Colección:Micro & nano technologies.
Temas:
Vaccines > Biotechnology.
Nanomedicine.
Vaccines > pharmacology
Nanomedicine
Vaccins > Biotechnologie.
Nanom�edecine.
MEDICAL > Pharmacology.
Vaccines > Biotechnology
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover; Title page; Copyright page; Contents; List of Contributors; Introduction; Chapter One
  • The Growing Influence of Nanotechnology in Our Lives; 1.1
  • Nanomaterials and Fabrication Techniques; 1.1.1
  • Nanoparticles; 1.1.2
  • Nanowires; 1.1.3
  • Nanofilms; 1.2
  • Nanomaterials in Modern Life; 1.2.1
  • Zero-dimensional nanostructures; 1.2.2
  • One-dimensional nanostructures; 1.2.3
  • Two-dimensional nanostructures; 1.3
  • Conclusions; References; Chapter Two
  • Nanotechnology in Medical Research; 2.1
  • Introduction; 2.2
  • Diagnostic Nanoparticles; 2.2.1
  • Imaging agents.
  • 2.2.1.1
  • Contrast Agents for MRI2.2.1.2
  • Contrast Agents for CT; 2.2.1.3
  • PET and SPECT Tracers; 2.2.1.4
  • Optical Imaging Agents; 2.2.1.5
  • Ultrasound Imaging Agents; 2.2.1.6
  • Photoacoustic Contrast Agents; 2.2.2
  • Nanoparticle biosensors; 2.2.2.1
  • Sensing of Biomarkers; 2.2.2.2
  • Sensing of Infectious Diseases; 2.3
  • Therapeutic Nanoparticles; 2.3.1
  • Delivery systems and therapeutics; 2.3.2
  • Drug loading; 2.3.3
  • Targeted nanoparticles; 2.4
  • Multimodal Nanoparticles; 2.4.1
  • Multimodal imaging agents; 2.4.2
  • Theranostics; 2.4.3
  • Personalized multimodal therapy.
  • 2.5
  • In DevelopmentReferences; Chapter Three
  • Introduction to Vaccines and Vaccination; 3.1
  • Introduction to Vaccines and Vaccination; 3.1.1
  • A brief history of vaccines and vaccination; 3.1.2
  • The rationale behind vaccination; 3.1.3
  • Vaccine subtypes; 3.1.4
  • Immunization sites and devices; 3.1.4.1
  • Intramuscular Immunizations; 3.1.4.2
  • Subcutaneous Immunizations; 3.1.4.3
  • Cutaneous Immunizations; 3.1.4.4
  • Mucosal Immunizations; 3.2
  • Challenges; 3.3
  • Conclusions; References; Chapter Four
  • Overview of the Immune System; 4.1
  • A Short History of Immunology.
  • 4.2
  • Immune Responses to Infection4.3
  • Innate Immunity; 4.4
  • Induced Innate Immune System; 4.4.1
  • Phagocytes; 4.4.2
  • Pattern recognition by innate immune cells; 4.4.3
  • Dendritic cells; 4.4.4
  • Natural killer cells; 4.4.5
  • Mast cells and basophils; 4.5
  • The Adaptive Immune System; 4.6
  • Cells of the Adaptive Immune System; 4.6.1
  • T cells; 4.6.2
  • B cells; 4.6.3
  • Immunological memory; 4.7
  • Immunoglobulin Classes and Function; 4.8
  • Blurring the Lines Between Innate and Adaptive Immunity; 4.8.1
  • Innate-like lymphocytes; 4.8.2
  • Innate immune cells with memory.
  • 4.9
  • Concluding RemarksReferences; Chapter Five
  • The Role of Antigen Presentation and Innate Immunity During Immune Induction by Particulate Antigens; 5.1
  • Introduction to Vaccine Adjuvants; 5.2
  • The Innate Immune System as a Regulator of Adaptive Immunity; 5.2.1
  • The relationship between innate and adaptive immune systems; 5.2.2
  • Pattern recognition receptors and their ligands; 5.3
  • Nanoparticle Vaccine Delivery Systems; 5.3.1
  • Antigens attached to inert nanoparticles; 5.3.2
  • Particulate antigens containing innate immune stimulators.
  • 5.4
  • Targeting APCs at the Site of Vaccination and in the Draining Lymph Node.

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