Discovery and development of antidiabetic agents from natural products : natural product drug discovery /

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Brahmachari, Goutam (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam, Netherlands : Elsevier, [2017]
Colección:Natural product drug discovery.
Temas:
Hypoglycemic agents.
Natural products.
Hypoglycemic Agents
Hypoglyc�emiants.
Produits naturels.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Hypoglycemic agents
Natural products
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; Discovery and Development of Antidiabetic Agents From Natural Products: Natural Product Drug Discovery; Discovery and Development of Antidiabetic Agents From Natural Products: Natural Product Drug Discovery; Copyright; Dedication; Contents; List of Contributors; Editor Biography; Foreword; NATURAL PRODUCT DRUG DISCOVERY-THE ROAD AHEAD; Preface; 1
  • Andrographolide: A Molecule of Antidiabetic Promise; 1. INTRODUCTION; 2. THE MOLECULE; 3. EXTRACTION, PURIFICATION, AND CHARACTERIZATION DATA OF ANDROGRAPHOLIDE
  • 3.1 Extraction and Purification of Andrographolide From Andrographis paniculata Nees3.2 Physical and Spectral Data of Andrographolide; 4. TOTAL SYNTHESIS OF ANDROGRAPHOLIDE; 5. ANTIDIABETIC POTENTIAL OF NATURAL ANDROGRAPHOLIDE AND ITS SEMISYNTHETIC DERIVATIVES; 5.1 Antidiabetic Studies With Natural Andrographolide and Deoxyandrographolide; 5.2 Antidiabetic Studies With Semisynthetic Derivatives of Andrographolide; 6. STUDIES ON PHARMACOKINETICS AND METABOLISM; 7. SAFETY ASPECTS OF ANDROGRAPHOLIDE; 8. CONCLUDING REMARKS; LIST OF ABBREVIATIONS; ACKNOWLEDGMENTS; REFERENCES
  • 2
  • Computer-Aided Discovery of Glycogen Phosphorylase Inhibitors Exploiting Natural Products1. INTRODUCTION; 2. COMPUTER-AIDED DRUG DESIGN METHODS; 3. APPLICATIONS OF COMPUTATION TO GLYCOGEN PHOSPHORYLASE INHIBITOR DESIGN; 3.1 Introduction; 3.2 Catalytic Site; 3.3 Allosteric Site; 3.4 New Allosteric Site; 3.5 Inhibitor Site; 4. CONCLUDING REMARKS; LIST OF ABBREVIATIONS; ACKNOWLEDGMENTS; REFERENCES; 3
  • Identification and Extraction of Antidiabetic Antioxidants From Natural Sources; 1. INTRODUCTION; 2. CURCUMIN: EXTRACTION, IDENTIFICATION, AND ANTIDIABETIC-ANTIOXIDANT POTENTIAL
  • 2.1 Extraction and Estimation of Curcumin2.1.1 Extraction of Curcuminoid; 2.1.1.1 Solvent Extraction; 2.1.1.2 Maceration Extraction; 2.1.1.3 Microwave-Assisted Extraction; 2.1.1.4 Sonication Extraction; 2.1.1.5 Slurry Extraction; 2.1.2 Estimation of Curcuminoid; 2.1.2.1 Spectrophotometric Analysis; 2.1.2.2 Separation of Curcuminoids by Thin Layer Chromatography; 2.1.3 Separation of Individual Components of Curcuminoid; 2.2 Curcumin as an Antioxidant; 2.3 Curcumin as an Antidiabetic Agent; 2.4 Curcumin as an Antiinflammatory Agent
  • 2.5 Mechanism of Curcumin-Induced Protective Action in Diabetes2.5.1 Protective Action on Pancreatic Damage; 2.5.2 Protective Action on Liver Damage; 2.5.3 Protective Action on Testicular Damage; 2.6 Clinical Impact of Curcumin on Human; 2.7 Bioavailability of Curcumin; 2.8 Toxicity of Curcumin; 3. MANGIFERIN: EXTRACTION, IDENTIFICATION, AND ANTIDIABETIC-ANTIOXIDANT POTENTIAL; 3.1 Extraction and Identification of Mangiferin; 3.1.1 Extraction and Isolation of Mangiferin; 3.1.1.1 Extraction From the Bark of Mangifera indica; 3.1.1.2 Extraction From the Flowering Buds of Mangifera indica

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