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Discovery and development of antidiabetic agents from natural products : natural product drug discovery /
Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam, Netherlands :
Elsevier,
[2017]
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| Colección: | Natural product drug discovery.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Discovery and development of antidiabetic agents from natural products : |b natural product drug discovery / |c edited by Goutam Brahmachari. |
| 264 | 1 | |a Amsterdam, Netherlands : |b Elsevier, |c [2017] | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Natural Product Drug Discovery | |
| 588 | 0 | |a Print version record. | |
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. | ||
| 505 | 0 | |a Front Cover; Discovery and Development of Antidiabetic Agents From Natural Products: Natural Product Drug Discovery; Discovery and Development of Antidiabetic Agents From Natural Products: Natural Product Drug Discovery; Copyright; Dedication; Contents; List of Contributors; Editor Biography; Foreword; NATURAL PRODUCT DRUG DISCOVERY-THE ROAD AHEAD; Preface; 1 -- Andrographolide: A Molecule of Antidiabetic Promise; 1. INTRODUCTION; 2. THE MOLECULE; 3. EXTRACTION, PURIFICATION, AND CHARACTERIZATION DATA OF ANDROGRAPHOLIDE | |
| 505 | 8 | |a 3.1 Extraction and Purification of Andrographolide From Andrographis paniculata Nees3.2 Physical and Spectral Data of Andrographolide; 4. TOTAL SYNTHESIS OF ANDROGRAPHOLIDE; 5. ANTIDIABETIC POTENTIAL OF NATURAL ANDROGRAPHOLIDE AND ITS SEMISYNTHETIC DERIVATIVES; 5.1 Antidiabetic Studies With Natural Andrographolide and Deoxyandrographolide; 5.2 Antidiabetic Studies With Semisynthetic Derivatives of Andrographolide; 6. STUDIES ON PHARMACOKINETICS AND METABOLISM; 7. SAFETY ASPECTS OF ANDROGRAPHOLIDE; 8. CONCLUDING REMARKS; LIST OF ABBREVIATIONS; ACKNOWLEDGMENTS; REFERENCES | |
| 505 | 8 | |a 2 -- Computer-Aided Discovery of Glycogen Phosphorylase Inhibitors Exploiting Natural Products1. INTRODUCTION; 2. COMPUTER-AIDED DRUG DESIGN METHODS; 3. APPLICATIONS OF COMPUTATION TO GLYCOGEN PHOSPHORYLASE INHIBITOR DESIGN; 3.1 Introduction; 3.2 Catalytic Site; 3.3 Allosteric Site; 3.4 New Allosteric Site; 3.5 Inhibitor Site; 4. CONCLUDING REMARKS; LIST OF ABBREVIATIONS; ACKNOWLEDGMENTS; REFERENCES; 3 -- Identification and Extraction of Antidiabetic Antioxidants From Natural Sources; 1. INTRODUCTION; 2. CURCUMIN: EXTRACTION, IDENTIFICATION, AND ANTIDIABETIC-ANTIOXIDANT POTENTIAL | |
| 505 | 8 | |a 2.1 Extraction and Estimation of Curcumin2.1.1 Extraction of Curcuminoid; 2.1.1.1 Solvent Extraction; 2.1.1.2 Maceration Extraction; 2.1.1.3 Microwave-Assisted Extraction; 2.1.1.4 Sonication Extraction; 2.1.1.5 Slurry Extraction; 2.1.2 Estimation of Curcuminoid; 2.1.2.1 Spectrophotometric Analysis; 2.1.2.2 Separation of Curcuminoids by Thin Layer Chromatography; 2.1.3 Separation of Individual Components of Curcuminoid; 2.2 Curcumin as an Antioxidant; 2.3 Curcumin as an Antidiabetic Agent; 2.4 Curcumin as an Antiinflammatory Agent | |
| 505 | 8 | |a 2.5 Mechanism of Curcumin-Induced Protective Action in Diabetes2.5.1 Protective Action on Pancreatic Damage; 2.5.2 Protective Action on Liver Damage; 2.5.3 Protective Action on Testicular Damage; 2.6 Clinical Impact of Curcumin on Human; 2.7 Bioavailability of Curcumin; 2.8 Toxicity of Curcumin; 3. MANGIFERIN: EXTRACTION, IDENTIFICATION, AND ANTIDIABETIC-ANTIOXIDANT POTENTIAL; 3.1 Extraction and Identification of Mangiferin; 3.1.1 Extraction and Isolation of Mangiferin; 3.1.1.1 Extraction From the Bark of Mangifera indica; 3.1.1.2 Extraction From the Flowering Buds of Mangifera indica | |
| 650 | 0 | |a Hypoglycemic agents. | |
| 650 | 0 | |a Natural products. | |
| 650 | 2 | |a Hypoglycemic Agents |0 (DNLM)D007004 | |
| 650 | 6 | |a Hypoglyc�emiants. |0 (CaQQLa)201-0022942 | |
| 650 | 6 | |a Produits naturels. |0 (CaQQLa)201-0030192 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Clinical Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Diseases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Evidence-Based Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a Hypoglycemic agents |2 fast |0 (OCoLC)fst00966014 | |
| 650 | 7 | |a Natural products |2 fast |0 (OCoLC)fst01034390 | |
| 700 | 1 | |a Brahmachari, Goutam, |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Discovery and Development of Antidiabetic Agents from Natural Products. |d [Place of publication not identified] : Elsevier Science Ltd 2016 |z 9780128094501 |w (OCoLC)958795927 |
| 830 | 0 | |a Natural product drug discovery. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128094501 |z Texto completo |