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245 0 0 |a Nanotechnology and the brain /  |c edited by Khuloud T. Al-Jamal. 
264 1 |a Cambridge, MA :  |b Academic Press is an imprint of Elsevier,  |c 2016. 
300 |a 1 online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a International review of neurobiology ;  |v volume 130 
500 |a Includes index. 
588 0 |a Online resource; title from PDF title page (ScienceDirect, viewed September 28, 2016). 
505 0 |a Front Cover; Nanotechnology and the Brain; Copyright; Contents; Contributors; Preface; Chapter One: Recent Trends in Nanotechnology Toward CNS Diseases: Lipid-Based Nanoparticles and Exosomes for Targeted The ...; 1. Introduction; 2. Lipid-Based Nanoparticles for Nucleic Acid and Drug Delivery to the CNS; 2.1. Ischemic Stroke; 2.2. Neuropathic Pain; 2.3. Alzheimer�s Disease; 2.4. Parkinson�s Disease; 2.5. Machado-Joseph Disease; 2.6. Multiple Sclerosis; 2.7. CNS Tumors; 2.8. Other Neurological Disorders; 3. Exosomes as Delivery Systems for CNS Diseases; 4. Conclusions; Acknowledgments 
505 8 |a 1. Introduction2. NPs for Brain Cancer; 2.1. Physiopathology; 2.1.1. Brain Tumors and Glioblastoma; 2.1.1.1. Brain Tumors; 2.1.1.2. Glioblastoma; 2.2. Standard Treatments; 2.2.1. Current GB Therapies; 2.2.1.1. Surgery; 2.2.1.2. Chemotherapy; 2.2.1.3. Radiotherapy; 2.2.2. Therapeutic Limitations; 2.3. NP-Based GB Therapy; 2.3.1. Advantages; 2.3.1.1. Suitable Drugs; 2.3.1.2. Pharmacokinetic Modulation; 2.3.1.3. Targeting; 2.3.1.4. Crossing Barrier Facilitation; 2.3.1.5. Theranostic Medicine; 2.3.1.6. Gene Therapy; 2.3.2. Preclinical Phase and Clinical Trials; 2.3.2.1. Preclinical Phase 
505 8 |a 2.3.2.2. Clinical Trials2.3.3. Limits of NP-Based GB Therapies; 2.4. Novel NP-Based Approaches for GB Treatment; 2.5. Conclusion on the Application of Nanomedicine to GB Therapy; 3. NPs for Alzheimer�s Disease Therapy; 3.1. Physiopathology; 3.1.1. Neurodegenerative Diseases and Alzheimer�s Disease; 3.1.1.1. Neurodegenerative Diseases; 3.1.1.2. Alzheimer�s Disease; 3.2. Conventional Treatments; 3.2.1. Current Therapy and Research Strategies; 3.2.1.1. Therapeutics Based on ``Cholinergic Hypothesis��; 3.2.1.2. Therapeutics Based on ``Tau Cascade Hypothesi��s 
505 8 |a 3.2.1.3. Therapeutics Based on ``Amyloid Cascade Hypothesis��3.2.2. Limitations of ADs Therapies; 3.3. NP-Based AD Therapies; 3.3.1. Nanotechnological Improvement and Innovation; 3.3.1.1. Nanotechnological Improvement; 3.3.1.2. Nanotechnological Innovation; 3.3.2. Preclinical Phase and Clinical Trials; 3.4. Conclusions on the Application of Nanomedicine to Alzheimer Disease Therapy; 4. Nanotechnology for the Treatment of Stroke; 4.1. Physiopathology of Stroke; 4.2. Current Stroke Therapies; 4.2.1. Thrombolysis; 4.2.2. Neuroprotective Therapy; 4.3. NP-Based Stroke Therapy; 4.3.1. Advantages 
650 0 |a Nanomedicine. 
650 0 |a Nanobiotechnology. 
650 0 |a Nanotechnology. 
650 2 |a Nanomedicine  |0 (DNLM)D050997 
650 2 |a Nanotechnology  |0 (DNLM)D036103 
650 6 |a Nanobiotechnologie.  |0 (CaQQLa)000286131 
650 6 |a Nanom�edecine.  |0 (CaQQLa)201-0448752 
650 6 |a Nanotechnologie.  |0 (CaQQLa)201-0225435 
650 7 |a HEALTH & FITNESS / Holism  |2 bisacsh 
650 7 |a HEALTH & FITNESS / Reference  |2 bisacsh 
650 7 |a MEDICAL / Alternative Medicine  |2 bisacsh 
650 7 |a MEDICAL / Atlases  |2 bisacsh 
650 7 |a MEDICAL / Essays  |2 bisacsh 
650 7 |a MEDICAL / Family & General Practice  |2 bisacsh 
650 7 |a MEDICAL / Holistic Medicine  |2 bisacsh 
650 7 |a MEDICAL / Osteopathy  |2 bisacsh 
650 7 |a Nanotechnology  |2 fast  |0 (OCoLC)fst01032639 
650 7 |a Nanobiotechnology  |2 fast  |0 (OCoLC)fst01894713 
650 7 |a Nanomedicine  |2 fast  |0 (OCoLC)fst01744350 
700 1 |a Al-Jamal, Khuloud,  |e editor. 
776 0 8 |i Print version:  |z 9780128046364  |z 0128046368  |w (OCoLC)950450178 
830 0 |a International review of neurobiology ;  |v v. 130. 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/bookseries/00747742/130  |z Texto completo