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Anticandidal Agents.
Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules. Candida albicans is an opportunistic path...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
[Place of publication not identified] :
Elsevier Science,
2016.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Anticandidal Agents; Copyright Page; Contents; List of Figures; List of Tables; 1 Introduction; Pathogenesis and Virulence; Genome and Proteome; Genetics; Metabolome; 2 Host-Pathogen Interaction; Morphogenesis; Immune Responses; Delayed-Type Hypersensitivity; Pattern Recognition Receptors; TH Cell Response; 3 Antifungals Used Against Candidiasis; Azoles; Activity and Mechanism of Action; Azole Variants and Their Structure; Ketoconazole; Itraconazole; Fluconazole; Voriconazole; Posoconazole; Ravuconazole; Terconazole; Other Notable Triazoles Include; Polyenes.
- Activity and Mechanism of ActionStructure and Variants; Amphotericin B; Nystatin; Natamycin; Echinocandins; Activity and Mechanism of Action; Echinocandins Variants; Caspofungin; Micafungin; Anidulafungin; Pneumocandins; Echinocandin B; Cilofungin; Allylamines; Activity and Mechanism of Action; Variants of Allylamines; Terbinafine; Naftifine; Pyrimidines; Activity and Mechanism of Action; Pyrimidine Variants; 5-FC or Flucytosine; Thiocarbamates and Morpholines; Tolnaftate; Morpholines; Other Inhibitors; Cell Wall Synthesis Inhibitors; Chitin Biosynthesis Inhibitors.
- Ergosterol Biosynthesis InhibitorGlucan Synthesis Inhibitors; Novel Inhibitors; Expected Drugs (Compounds in Pipeline); SCY078; Ara-sertaconazole Nitrate; VT-1161; MGCD290; E1210; T-2307; ASP9726; Biafungin (CD101); Isavuconazole; Albaconazole; BQM-Bis [1, 6]quinolizinium 8-Methyl-Salt; Quinazolines; Indole and its Derivatives; Inhibitor Molecules; Sordarins; Tacrolimus; Ascomycin; Milbemycin; Unnarmicin A and Unnarmicin C; Verapamil; Disulfiram; Enniatin B; Trichostatin A; Levofloxacin and Derivatives; Differential Expression of Genes in Response to Drugs; 4 Drug Resistance in Candida.
- Emergence of Drug ResistanceSpread of Drug Resistance; Persistence of Drug Resistance; International Data; National Data; Multidrug Resistance; 5 Multidrug Resistance and Transporters; Overview of Efflux Pumps; ABC Transporters; MFS Transporters; Fungal Efflux-Mediated Drug Resistance; Overcoming Efflux-Mediated Drug Resistance; 6 Potential Anticandidal Targets; Surface Targets; ABC Transporters; Key Factors; MFS Transporters; QDR; Cellular Targets; Cross Talk; 7 Drug Development Strategies; In Vitro Based; Biochemical Estimation; Toxicity Assay; Drug Susceptibility; Effects on Biofilm.
- In Vivo BasedBioavailability; Toxicity; ADME; Absorption and Distribution; Metabolism and Excretion; Pharmacokinetics and Pharmacodynamics; In Silico Based; Computer-Aided Drug Discovery and Development; Molecular Docking; Molecular Modeling; Virtual Screening; Quantitative Structured Activity Relationship; 8 Conclusion; Abbreviations; Bibliography; Back Cover.