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Molecular and cellular basis of metastasis /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Saint Louis :
Elsevier Science,
2016.
|
| Colección: | Advances in Cancer Research ;
v. 132. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Molecular and Cellular Basis of Metastasis: Road to Therapy; Copyright; Contents; Contributors; Preface; Chapter One: Detecting Tumor Metastases: The Road to Therapy Starts Here; 1. Introduction; 2. Preclinical In Vitro and In Vivo Models of Metastasis; 2.1. In Vitro Models; 2.2. In Vivo Models; 3. Approaches Currently Used to Detect Metastatic Lesions (on a Preclinical Level); 3.1. Lab Tests/Histopathology; 3.2. Noninvasive Blood Tests; 3.3. Small Animal Imaging; 3.4. Molecular-Genetic Imaging (Promoter-Based Protocols); 3.5. Circulating Tumor Cells.
- 4. Approaches Used to Detect Metastatic Lesions (on a Clinical Level)4.1. Biomarkers for Metastasis; 4.2. Imaging Procedures; 4.3. Circulating Tumor Cells; 5. Metastasis Detection/Therapy: Combining Imaging with Therapy (Theranostics); 6. Challenges Faced in Detecting Metastatic Cells; 7. Conclusions and Future Directions; Acknowledgments; References; Chapter Two: The Relationship Between Dormant Cancer Cells and Their Microenvironment; 1. Introduction; 2. Models to Study Tumor Cell Dormancy; 3. Intrinsic and Extrinsic Signals Converge to Induce Tumor Cell Dormancy.
- 4. Cooperative Extrinsic Signals Induce Dormancy Within the Bone Microenvironment5. Endosteal and Perivascular Niches Support Cancer Cell Dormancy; 6. Reactivation from Dormancy; 7. The Immune System and Dormancy; 8. Summary and Outlook; References; Chapter Three: Defining the Influence of Germline Variation on Metastasis Using Systems Genetics Approaches; 1. Introduction; 2. Hereditary Factors Associated with Cancer Aggressiveness and Metastasis in Human Populations; 2.1. Epidemiological Analysis; 2.2. Genetic Analysis Human Cohorts.
- 3. Systems Genetics Approaches to Identify Hereditary Modifiers of Metastasis3.1. Breast Cancer; 3.2. Prostate Cancer; 3.3. Melanoma; 4. Conclusions; Acknowledgments; References; Chapter Four: Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic ... ; Concluding Thoughts; Acknowledgments; References; Chapter Five: Immune Regulation of the Metastatic Process: Implications for Therapy; 1. Introduction; 2. Key Players; 2.1. Monocytes; 2.2. Macrophages; 2.3. Neutrophils; 2.4. T Lymphocytes; 2.5. Natural Killer Cells.
- 3. Invasion and Intravasation3.1. Macrophages; 3.2. Neutrophils; 3.3. T Lymphocytes; 4. Survival and Extravasation; 4.1. Monocytes; 4.2. Neutrophils; 4.3. T Lymphocytes; 4.4. NK Cells; 5. Ectopic Growth; 5.1. Macrophages; 5.2. Neutrophils; 5.3. T Lymphocytes; 5.4. NK Cells; 6. Therapeutic Implications; Acknowledgments; References; Chapter Six: MicroRNA and Metastasis; 1. MicroRNAs; 1.1. Noncoding RNAs and the Discovery of MicroRNAs; 1.2. miRNA Biogenesis and Mechanisms of Action; 1.3. miRNA Functions; 2. miRNAs in Cancer; 2.1. Deregulated Expression of miRNAs in Cancer.