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The chemistry and biology of nitroxyl (HNO) /
Annotation
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam, Netherlands :
Elsevier,
2016, �2017.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; The Chemistry and Biology of Nitroxyl (HNO); Copyright Page; Contents; List of Contributors; Introduction: A Bit of History and General Facts About Nitroxyl: From Interstellar Molecule to Biological Gasotransmitter; References; 1 HNO: Redox Chemistry and Interactions With Small Inorganic Molecules; 1.1 Introduction; 1.2 Dimerization; 1.3 Reaction with molecular oxygen; 1.4 Reaction with NO; 1.5 Reaction with H2S; 1.6 Redox-related reactions; References; 2 HNO Donors: Angeli's Salt and Related Diazeniumdiolates; 2.1 Introduction; 2.2 Angeli's salt.
- 2.2.1 Synthesis and use of Angeli's salt2.2.2 Structural analysis; 2.2.3 Mechanism of decomposition; 2.2.4 Advantages and disadvantages; 2.3 Diazeniumdiolates; 2.3.1 Synthesis of primary amine diazeniumdiolates; 2.3.2 Structural analysis; 2.3.3 Mechanism of decomposition; 2.3.4 Advantages/disadvantages; 2.4 Diazeniumdiolate-based HNO-releasing prodrugs; 2.4.1 Synthesis of primary amine diazeniumdiolate ester derivatives; 2.4.2 Structural analysis; 2.4.3 Mechanism of decomposition; 2.4.4 Advantages/disadvantages; 2.5 Acyl nitroso compounds as HNO donors; 2.6 Conclusions; Acknowledgments.
- AbbreviationsReferences; 3 Hydroxylamines With Organic-Based Leaving Groups as HNO Donors; 3.1 Introduction; 3.2 Synthesis; 3.3 Piloty's acid and its derivatives; 3.4 Cyanamide; 3.5 Hydroxylamines with carbon-bound leaving groups; 3.6 Summary; Acknowledgment; References; 4 Mechanistic Aspects of HNO Production from Hydroxylamine and Derivatives; 4.1 Hydroxylamine in chemical reactions; 4.2 Hydroxylamine derivatives and related compounds; 4.2.1 Hydroxylamine in biological systems; References; 5 HNO Generation From NO, Nitrite, Inorganic or Organic Nitrosyls, and Crosstalk With H2S.
- 5.1 HNO generation from NO and MNOn5.1.1 Basic considerations; 5.1.2 Metal-mediated processes; 5.1.2.1 Outer-sphere electron transfer; 5.1.2.2 Coordination and inner(outer)-sphere electron transfer; 5.1.2.2.1 MNO8 complexes; 5.1.2.2.2 MNO7 complexes and their reduction; 5.1.2.2.2.1 Heme/porphyrin MNO7 systems; 5.1.2.2.2.2 Low-spin nonheme MNO7 systems; 5.1.2.2.2.3 High-spin nonheme MNO7 systems; 5.1.2.2.3 MNO6 complexes; 5.1.2.3 Reduction by hydride; 5.1.2.4 Hydrogen atom transfer; 5.1.3 Metal-free processes; 5.1.3.1 Reduction of NO to HNO by vitamin C; 5.1.3.2 Reduction of NO to HNO by H2S.
- 5.2 HNO generation from nitrite and nitroso, NO+, species through the interplay with H2S and HSNO formation5.2.1 HNO generation through HSNO in the reaction of S-nitrosothiols or nitrite with H2S; 5.2.2 Metal-mediated HNO generation through HSNO in the reaction of nitrite or nitrosonium complexes with H2S; 5.2.2.1 Heme-catalyzed reaction between nitrite and H2S generates HSNO, HNO and NO; 5.2.2.2 Sodium nitroprusside with H2S generates HNO accompanied by conversion of toxic cyanide into thiocyanate; 5.3 Conclusion; References; 6 HNO-Thiol Relationship.