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International review of cell and molecular biology. Volume 326 /
International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. The series has a worldwide readership, maintaining its high standard by publishing invited articles on important and timely topics that are authored by prominent cell...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom :
Academic Press is an imprint of Elsevier,
2016.
|
| Colección: | International Review of Cell and Molecular Biology ;
Volume 326 |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a International review of cell and molecular biology. |n Volume 326 / |c edited by Kwang W. Jeon and Lorenzo Galluzzi. |
| 264 | 1 | |a London, United Kingdom : |b Academic Press is an imprint of Elsevier, |c 2016. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 0 | |a International Review of Cell and Molecular Biology ; |v Volume 326 | |
| 500 | |a Includes index. | ||
| 520 | |a International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. The series has a worldwide readership, maintaining its high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. | ||
| 588 | 0 | |a Online resource; title from PDF title page (ScienceDirect, viewed September 1, 2016). | |
| 505 | 0 | |a Cover ; Title Page; Copyright Page; Contents; Contributors; Dedication; Chapter One -- Sensing the Environment Through Sestrins: Implications for Cellular Metabolism ; Abstract; 1 Introduction; 2 Regulation and Function of Sestrins; 2.1 Regulation of Transcription of the Sestrin Family Members; 2.1.1 DNA Damage; 2.1.2 Oxidative Stress; 2.1.3 Nutrients and Oxygen Deprivation; 2.2 Sestrins as Antioxidant Proteins: Old Friends or New Foes?; 2.3 Sestrins are Regulators of mTOR; 2.3.1 The mTOR Complexes; 2.3.2 Regulation of mTORC1; 2.3.3 Sestrins Potentiate AMPK Activity | |
| 505 | 8 | |a 2.3.4 mTORC1 Regulation by the Sestrin-GATOR-Rags Axis2.3.5 Regulation of the mTORC2-Akt Pathway by Sestrins; 2.4 Sestrins and Autophagy; 2.4.1 Regulation of Autophagy; 2.4.2 Sestrins Promote Autophagy; 3 Sestrins are Sensors of Nutrient Availability and are Involved in Regulation of Metabolism; 3.1 Hypernutrition and Growth Factors; 3.2 Glucose; 3.3 Oxygen; 3.4 Amino Acids; 3.5 Lipids; 4 Conclusions and Perspectives; Acknowledgments; References; Chapter Two -- Metabolic Regulation of Apoptosis in Cancer ; Abstract; 1 Introduction; 2 Overview of Apoptosis Pathways; 2.1 Caspases | |
| 505 | 8 | |a 2.2 Intrinsic and Extrinsic Pathways2.3 Activation of Initiator Caspases; 2.4 Mitochondria Outer Membrane Permeabilization (MOMP); 3 Regulation of Apoptosis Through Glycolytic Pathway; 3.1 Hypoxia-Inducible Factor-1; 3.2 AKT; 3.3 BAD; 3.4 NOXA; 3.5 Caspase-2; 3.6 Cytochrome c; 4 p53 and Glucose Metabolism; 4.1 GLUT1/GLUT4 and HK2; 4.2 TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator); 4.3 Apoptosis-Inducing Factor and Synthesis of Cytochrome c Oxidase 2; 4.4 Glucose-6-Phosphate Dehydrogenase; 5 Regulation of Apoptosis by Lipid Metabolism; 5.1 Introduction of Sphingolipid Pathway | |
| 505 | 8 | |a 5.2 Pro-apoptotic Functions of Ceramide5.3 Role of Pathways That Regulate Ceramide Production; 5.3.1 Sphingomyelinase (SMase) Pathway; 5.3.2 De Novo Synthesis; 5.3.3 Salvage Pathway; 5.4 Fatty Acids; 6 Concluding Remarks; Acknowledgments; References; Chapter Three -- A Mechanistic Approach to the Development of Gene Therapy for Chronic Pain ; Abstract; 1 Introduction; 2 Basics of Gene Therapy; 2.1 Gene Transfer Mechanisms; 2.2 Various Viral Vectors and Their Characteristics; 3 Physiological Mechanisms of Nociception/Pain | |
| 505 | 8 | |a 3.1 Detection and Transmission of Nociceptive Signals Through the Nervous System3.1.1 From the Periphery to the SC; 3.1.2 Transmission at the First Relay, the SC; 3.1.3 Ascending Pathways and the Supraspinal Processing of Pain; 3.2 The Modulatory Systems of Pain Transmission; 3.2.1 Spinal Control of Pain, or the Gate-Control Theory; 3.2.2 Supraspinal Control of Pain, or the Descending Inhibitory Pathway; 4 Chronic Neuropathic Pain; 4.1 Anatomical, Cellular, and Molecular Basis of Neuropathic Pain; 4.2 Gene Therapy for Neuropathic Pain; 4.3 Perspectives on Gene Therapy for Neuropathic Pain | |
| 650 | 0 | |a Cytology. | |
| 650 | 0 | |a Molecular biology. | |
| 650 | 2 | |a Cell Biology |0 (DNLM)D003585 | |
| 650 | 2 | |a Molecular Biology |0 (DNLM)D008967 | |
| 650 | 2 | |a Cytology |0 (DNLM)D000093222 | |
| 650 | 6 | |a Cytologie. |0 (CaQQLa)201-0040099 | |
| 650 | 6 | |a Biologie mol�eculaire. |0 (CaQQLa)201-0064024 | |
| 650 | 7 | |a molecular biology. |2 aat |0 (CStmoGRI)aat300054470 | |
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| 650 | 7 | |a Cytology |2 fast |0 (OCoLC)fst00886282 | |
| 650 | 7 | |a Molecular biology |2 fast |0 (OCoLC)fst01024734 | |
| 700 | 1 | |a Galluzzi, Lorenzo, |e editor. | |
| 700 | 1 | |a Jeon, Kwang W., |e editor. | |
| 776 | 0 | 8 | |i Print version : |z 9780128048054 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/19376448/326 |z Texto completo |