Conquering RAS : from biology to cancer therapy /

Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers....

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Azmi, Asfar S. (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London, UK : Academic Press is an imprint of Elsevier, [2017]
Temas:
Ras oncogenes.
Genes, ras
Oncog�enes ras.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Ras oncogenes
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; Conquering RAS: From Biology to Cancer Therapy; Conquering RAS: From Biology to Cancer Therapy; Copyright; Dedication; Contents; List of Contributors; Acknowledgments; Introduction; 01
  • RAS Cancer Biology ; 1
  • Ras and RASSF Effector Proteins ; INTRODUCTION; The RASSF Family of Proteins; RAS AND RASSF1; RAS AND RASSF5 (NORE1); RAS AND RASSF2; RAS AND RASSF3; RAS AND RASSF4 (AD037); RAS AND RASSF6; EFFECTS OF RASSF PROTEINS ON MITOGENIC RAS EFFECTORS; THERAPEUTIC RAMIFICATIONS; CONCLUSION; GLOSSARY; LIST OF ACRONYMS AND ABBREVIATIONS; REFERENCES
  • 2
  • Ras and the Hippo Pathway in Cancer INTRODUCTION; THE HIPPO TUMOR SUPPRESSOR PATHWAY; MST AND LATS AS THE CENTRAL MAMMALIAN KINASES UNDER THE INFLUENCE OF HIPPO SIGNALING; YAP SIGNALING AND ITS REGULATION BY HIPPO; CONCLUSIONS AND FUTURE DIRECTIONS; REFERENCES; 3
  • The Many Roles of Ral GTPases in Ras-Driven Cancer ; INTRODUCTION; RAL REGULATION; RalGEFs; RalGAPs; Localization; RAL EFFECTORS; RalBP1; Exocyst; Additional Effectors; RAL IN MODEL SYSTEMS; RAL IN TUMORIGENESIS; INHIBITION OF RAL; CONCLUSIONS AND FUTURE DIRECTIONS; REFERENCES
  • 4
  • The Biology, Prognostic Relevance, and Targeted Treatment of Ras Pathway-Positive Childhood Acute Lymphoblastic Leukemia INTRODUCTION; CHILDHOOD ALL; RAS PATHWAY ACTIVATION; ARE RAS PATHWAY MUTATIONS AN INITIATING OR SECONDARY EVENT?; DISEASE EVOLUTION; PROGNOSTIC SIGNIFICANCE; TARGETED THERAPIES; CONCLUSIONS; LIST OF ACRONYMS AND ABBREVIATIONS; REFERENCES; 5
  • Oncogenic KRAS and the Inflammatory Micro-Environment in Pancreatic Cancer ; ONCOGENIC KRAS DRIVES PANCREATIC CANCER DEVELOPMENT; THE IMPORTANCE OF INFLAMMATION IN PDAC DEVELOPMENT
  • INTER-RELATION BETWEEN ONCOGENIC KRAS AND INFLAMMATION IN PANCREATIC CANCEROncogenic Kras Induces Inflammatory Pathways in Pancreatic Cancer; Inflammation Reciprocally Promotes Kras Over-activation; OBESITY-RELATED INFLAMMATION PROMOTES PANCREATIC CANCER DEVELOPMENT; POTENTIAL TARGETS FOR INTERVENTIONS; CONCLUSION; LIST OF ACRONYMS AND ABBREVIATIONS; REFERENCES; 6
  • Activation of Ras by Post-Translational Modifications ; INTRODUCTION; POST-TRANSLATIONAL MODIFICATIONS OF RAS; Prenylation; The CAAX Processing; The Enzymes for Prenylation; Farnesyltransferase; Geranylgeranyltransferase Type I
  • Ras Converting Enzyme 1Isoprenylcysteine Carboxyl Methyltransferase; Targeting Ras Prenylation; Palmitoylation and De-palmitoylation Cycle; Phosphorylation; Ubiquitination; Acetylation; S-Nitrosylation; Bacterial Toxins and Exoenzymes; CONCLUSIONS; LIST OF ACRONYMS AND ABBREVIATIONS; ACKNOWLEDGMENT; REFERENCES; 7
  • Cross Talk Between Snail and Mutant K-Ras Contributes to Pancreatic Cancer Progression ; INTRODUCTION; K-RAS AND PANCREATIC CANCER PROGRESSION; EPITHELIAL-TO-MESENCHYMAL TRANSITION AND PANCREATIC CANCER PROGRESSION

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