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Genetics, genomics and fish phenomics /
Genetics, Genomics and Fish Phenomics provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics. The book continually publishes important reviews of the broadest interest to...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
[San Diego, California] :
Academic Press : Elsevier Inc.,
2016.
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| Colección: | Advances in genetics ;
v. 95. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Genetics, Genomics and Fish Phenomics; Serial Editors; Genetics, Genomics and Fish Phenomics; Copyright; Contents; CONTRIBUTORS; One
- Studying the Evolution of the Vertebrate Circadian Clock: The Power of Fish as Comparative Models ; 1. INTRODUCTION; 1.1 What Are Circadian Clocks and Why Should We Study Them?; 1.2 Why Use Fish Genetic Models to Study Clocks?; 2. HOW DO FISH CLOCKS DIRECTLY SENSE LIGHT?; 2.1 Light-Inducible Gene Expression; 2.2 Peripheral Photoreceptors; 3. HOW DO FISH (AND CLOCKS) ADAPT DURING EVOLUTION UNDER PERPETUAL DARKNESS?; 3.1 Different Cave Environments.
- 3.2 Blind Clocks in Phreatichthys andruzzii3.3 Differences Between Surface and Cave Clocks in Astyanax; 3.4 Has the Astyanax Light-Response Altered Within Cave Strains?; 3.5 Astyanax in the Field; 3.6 Cavefish Sleep, Activity, and Metabolism; 4. OUTLOOK; ACKNOWLEDGMENTS; REFERENCES; Two
- Genomic and Transcriptomic Approaches to Study Cancer in Small Aquarium Fish Models ; 1. INTRODUCTION; 2. CANCER MODELS IN FISH; 3. GENOMIC APPROACHES; 4. TRANSCRIPTOMIC APPROACHES; 4.1 Melanoma; 4.2 Rhabdomyosarcoma; 4.3 Hepatocellular Carcinoma; 5. OUTLOOK; ACKNOWLEDGMENTS; REFERENCES.
- Three
- Gal4 Driver Transgenic Zebrafish: Powerful Tools to Study Developmental Biology, Organogenesis, and Neurosc ... 1. INTRODUCTION; 2. TOL2-MEDIATED TRANSGENESIS IN ZEBRAFISH; 3. THE GAL4-UAS SYSTEM IN ZEBRAFISH; 3.1 The Emergence of the Gal4-UAS System in Zebrafish; 3.2 Tol2-Mediated Gal4 Gene Trapping and Enhancer Trapping; 3.3 Additional Improvements in the Gal4-UAS System; 4. APPLICATIONS OF GAL4 DRIVERS; 4.1 Inhibition of Neuronal Activities via Targeted Expression of a Neurotoxin Gene; 4.2 Visualization of Neuronal Activities by Calcium Imaging.
- 4.3 Genetic Dissection of the Motor System4.4 The Architecture of Cerebellar Neural Circuits; 4.5 Proliferation and Differentiation of the Lateral Line System; 4.6 Spatiotemporal Functions of Notch Signaling; 5. CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Four
- Whole-Organism Cellular Pathology: A Systems Approach to Phenomics ; 1. INTRODUCTION; 1.1 Phenotype; 1.2 Phenomics and Phenome Projects; 1.3 Phenotype Omission Error; 1.4 Stereomicroscopy; 1.5 Molecular Imaging Versus Pan-Cellular Phenotyping; 1.6 Why Histological Phenotyping?; 2. LESSONS FROM LIGHT MICROSCOPY.
- 2.1 Early Tissue Phenotyping2.2 Histological Phenotyping in Medicine; 2.3 Histological Phenotyping in Zebrafish; 2.3.1 Method and Tool Development for Zebrafish Histology; 2.3.2 Lessons From Creating a Web-Based Histology Atlas; 2.3.3 Lessons From Phenotyping Zebrafish Using Histology; 2.3.3.1 From a Histological Mutagenesis Screen; 2.3.3.2 The Potential Utility of Volumetric Data; 2.3.3.3 From a Histological Screen of Existing Mutants Found by Stereomicroscopy; 3. WHOLE-ORGANISM CELLULAR PATHOLOGY AS A SYSTEMS APPROACH TO PHENOMICS; 3.1 The Need for Whole-Organism Cellular Pathology.