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Gene-environment interactions in psychiatry : nature, nurture, neuroscience /
Gene-Environment Interactions in Psychiatry: Nature, Nurture, Neuroscience begins with the basic aspects of gene-environment studies, such as basic genetics, principles of animals modeling, and the basic processes of how environmental factors affect brain and behavior, with part two describing the m...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press,
�2016.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover ; Title Page; Copyright Page; Dedication; Contents; Preface; Section I
- General Introduction; Chapter 1
- Introduction; Introduction; Gregor Johann Mendel; Mendel's first law of inheritance: the law of segregation; Mendel's second law of inheritance: the law of�independent assortment; The legacy of Mendel's work; Criticism of Mendel's work; The search for the Mendelian elements; The sex chromosomes; Beyond Mendel: the historical development of�molecular genetics; A brief history of behavioral genetics; References; Chapter 2
- The Genetic Basis of Behavior; Introduction.
- The molecular structure of DNADNA synthesis and replication; The structure of the genome; DNA transcription; The structure of genes; mRNA processing; mRNA translation; Genetic alterations; Single Nucleotide Variations; Tandem repeat sequences; Triplet repeats; Variable Number Tandem Repeats (VNTRs); Short insertions and deletions (indels); Copy number variations (CNVs); Chromosomal variations; References; Chapter 3
- Animal Modelling in Psychiatry; Introduction; Animal models; Screening Models; Pharmacological Bioassays; Neuroscience Bioassays; Simulation Models; Validating animal models.
- Genetic modulation in animalsForward Genetic Approaches; Reverse Genetic Approaches; Random Techniques; Targeted Techniques; References; Chapter 4
- The Environmental Basis of Behavior; Introduction; Environmental factors; Timing; The prenatal period; The perinatal period; The postnatal period; The adolescent period; Evaluating the role of environmental factors in animals; Developmental differences between rodents and humans; References; Chapter 5
- Environment Challenges and the Brain; Introduction; Early environmental challenges and structural brain changes.
- Early environmental challenges and the immune systemEarly environmental challenges and the hypothalamic pituitary adrenal (HPA) axis; Early environmental challenges and�neurotransmitter changes; Early environmental challenges and epigenetic changes; The molecular structure of chromosomes; The histone family of proteins; Epigenetic mechanisms
- introduction; Modification at the level of the nucleotides; DNA Methylation; RNA Interference; Chemical modification at the level of the histones; Histone Acetylation; Histone Phosphorylation; Histone Methylation; Additional Histone Modifications.
- The Complexity of Histone ModificationsStructural changes at the level of the nucleosome; Early environmental challenges and epigenetic changes; The Environment and Chromatin Modification; The Environment and Histone Modification; The Environment and Chromatin Remodeling; References; Section II
- Gene-Environment Interactions in Psychiatric Disorders; Chapter 6
- Drug Addiction; Introduction; Diagnosis and symptoms; The Epidemiology of drug addiction; The neurobiology of drug addiction; The pharmacological treatment of drug addiction; Replacement Therapies; Other Therapies.