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Tabla de Contenidos:
  • Cover ; Title page; Copyright page; Contents; Foreword; Preface; Acknowledgments; Chapter 1
  • Introduction to Alzheimer's Disease Biomarkers ; 1.1
  • Historical Background; 1.2
  • Important Events in Alzheimer's Disease (AD) Research; 1.3
  • Some Facts About Alzheimer's Disease; 1.4
  • Common Features of Alzheimer's Disease; 1.5
  • Classification of Alzheimer's Disease; 1.6
  • Risk Factors for Alzheimer's Disease; 1.7
  • Definition of a Biomarker; 1.7.1
  • A. Categorization of Biomarkers According to Their Role.
  • 1.7.2
  • B. Definition of Common Statistical Parameters to Quantify the Performance of Biomarkers1.8
  • Biomarkers of Alzheimer's Disease; 1.9
  • Future Focus: Detecting Preclinical Stages of Alzheimer's Disease; 1.10
  • Economic Impact of Alzheimer's Disease Biomarkers; 1.11
  • Conclusions; Bibliography; Chapter 2
  • Clinical Diagnosis of Alzheimer's Disease ; 2.1
  • Clinical Diagnosis of Alzheimer's Disease: Historical Perspective; 2.2
  • Neuropsychological Assessment Tests to Diagnose Alzheimer's Disease; 2.2.1
  • Mini-Mental State Examination; 2.2.2
  • Clock Drawing Test.
  • 2.2.3
  • Alzheimer's Disease Assessment Scale2.2.4
  • Neuropsychological Test Battery; 2.2.4.1
  • Other neuropsychological tests; 2.2.5
  • Clinical Dementia Rating; 2.2.6
  • Global Deterioration Scale; 2.2.7
  • Dementia Severity Rating Scale; 2.3
  • Neuropathology at Brain Autopsy to Diagnose Alzheimer's Disease; 2.4
  • Accuracy of Clinical Diagnosis of Alzheimer's Disease; 2.5
  • Alzheimer's Disease-Related Neurological Conditions; 2.5.1
  • Preclinical Alzheimer's Disease; 2.5.2
  • Mild Cognitive Impairment; 2.5.3
  • Non-Alzheimer's Dementias; 2.5.3.1
  • Vascular dementia; 2.5.3.2
  • Lewy body dementia.
  • 2.5.3.3
  • Frontotemporal dementia2.5.3.4
  • Creutzfeldt-Jacob disease; 2.5.3.5
  • Other non-AD dementias; 2.6
  • Challenges in Diagnosing Alzheimer's Disease; 2.6.1
  • Long Prodromal Stages; 2.6.2
  • Comorbidity With Non-Alzheimer's Disease Dementias; 2.6.3
  • Multiple Nongenetic and Genetic Factors; 2.6.4
  • Anomalous Alzheimer's Disease Neuropathology; 2.7
  • Comprehensive Alzheimer's Disease Diagnostic Framework; 2.8
  • Conclusions; Bibliography; Chapter 3
  • Neuroimaging Biomarkers in Alzheimer's Disease ; 3.1
  • Neuroimaging in Alzheimer's Disease; 3.1.1
  • Structural Neuroimaging.
  • 3.1.2
  • Functional Neuroimaging3.1.3
  • Molecular Neuroimaging; 3.2
  • Common Neuroimaging Alzheimer's Disease Biomarkers and Modalities; 3.3
  • Magnetic Resonance Imaging; 3.3.1
  • Structural MRI; 3.3.2
  • Functional MRI; 3.3.3
  • Magnetic Resonance Spectroscopy; 3.3.4
  • Advanced Magnetic Resonance Based Neuroimaging Modalities; 3.3.4.1
  • Diffusion tensor imaging; 3.3.4.2
  • Arterial spin labeling MRI; 3.3.4.3
  • Task free fMRI; 3.4
  • Positron Emission Tomography; 3.4.1
  • Amyloid Imaging by PET; 3.4.2
  • Glucose Metabolism Measurement by PET; 3.4.3
  • Brain Inflammation Imaging by PET.
  • 3.4.4
  • Tau Imaging by PET.