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Mammalian Preimplantation Development /
This volume covers mammalian preimplantation development, and includes contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as cell proliferation, cell differentiation, and biological significance.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press is an imprint of Elsevier,
2016.
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| Colección: | Current topics in developmental biology ;
v. 120. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Mammalian Preimplantation Development; Copyright; Contents; Contributors; Preface; 1. The Foundation of Mammalian Development; 2. The Unique Goals of Preimplantation Development; 3. The Events in Preimplantation and Peri-Implantation Development; 4. Recent Advances; 5. The Future of Preimplantation Development; 5.1. Genetic Diagnosis; 5.2. Genetic Intervention; 6. Cancer Stem Cells; References; Chapter One: Regulation of the Embryonic Cell Cycle During Mammalian Preimplantation Development; 1. Introduction; 1.1. The Somatic Cell Cycle; 2. The Preimplantation Cell Cycle.
- 2.1. Preparation for the First Cell Cycle2.2. Initial Embryonic Cell Cycles; 2.3. Maternal-Zygotic Transition, Genome Activation, and Epigenetic Reprogramming; 2.4. Blastocyst Formation and Compaction; 2.5. Late Preimplantation; 3. Regulation of the Preimplantation Cell Cycle; 3.1. Cdks and Cyclins; 3.2. Cellular Regulation of Cdk/Cyclin Complexes; 4. Mouse Models of Cell Cycle Regulators as Developmental Tools; 4.1. Cell Cycle-Related Cdk/Cyclin Complexes; 4.1.1. Cdk4/Cdk6; 4.1.2. D-Type Cyclins; 4.1.3. Cdk2; 4.1.4. The E-Type Cyclins; 4.1.5. The A-Type Cyclins; 4.1.6. Cdk1.
- 4.1.7. B-Type Cyclins4.1.8. Summary of Cell Cycle-Driving Cdks/Cyclins; 4.1.9. Cdk-Activating Kinase; 4.2. The Retinoblastoma and Related Pocket Proteins; 4.3. The E2F Family as a Downstream Target of Cdk/Cyclin Complexes; 4.4. Cdk3/Cyclin C; 4.5. Cdks and Transcription; 4.5.1. Cdk7/Cyclin H and Cdk9/Cyclin T; 4.5.2. Cdk8/Cyclin C; 5. DNA Damage and Checkpoint Signaling in the Preimplantation Embryo; 5.1. G1/S Checkpoint; 5.1.1. Embryonic Dependence on Cell Cycle Checkpoint Proteins; 5.1.2. ATR; 5.1.3. ATM; 5.1.4. Chk1/2; 5.2. Effectors of the G2/M Checkpoint; 5.2.1. The Cdc25 Phosphatases.
- 5.2.2. Wee1/Myt1 Kinases5.2.3. Polo-Like Kinase 1; 5.3. The Spindle Assembly Checkpoint; 5.3.1. Emi1; 6. Concluding Remarks; References; Chapter Two: Genome Duplication at the Beginning of Mammalian Development; 1. Basic Concepts; 1.1. Genome Duplication Is a Problem of Astronomical Proportions; 1.2. All Living Organisms Use the Replication Fork Paradigm; 1.3. Nuclear DNA Replication Begins in the Zygote; 1.4. The Same Replication Machinery Is Used from Zygote to Adult; 1.5. Not All Replication Origins Are Replicators; 2. Replication Origins Are Established in Two Steps.
- 2.1. Prereplication Complex Assembly (Origin Licensing)2.2. Preinitiation Complex Assembly (Origin Activation); 3. The First Mitotic Cell Division Is Universal; 4. The Second Cell Division Distinguishes Mammals from Nonmammals; 4.1. Cell Cleavage Gives Way to Cell Growth; 4.2. Cell Cycle Checkpoints Are Acquired at Different Stages in Development; 4.3. DNA Methylation Patterns Inherited from Gametes Are Erased; 4.4. Activation of ZGE Does Not Depend on DNA Replication; 5. Replication Origins Are Developmentally Regulated; 5.1. The "Jesuit Model" for Origin Selection.