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Ion channels in health and disease /
Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Of...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, UK :
Academic Press is an imprint of Elsevier,
2016.
|
| Colección: | Perspectives on translational cell biology series.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Ion channels in health and disease / |c edited by Geoffrey S. Pitt. |
| 264 | 1 | |a London, UK : |b Academic Press is an imprint of Elsevier, |c 2016. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Perspectives in translational cell biology | |
| 520 | |a Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research. | ||
| 500 | |a Includes index. | ||
| 588 | 0 | |a Online resource; title from PDF title page (ScienceDirect, viewed July 20, 2016). | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Front Cover; ION CHANNELS IN HEALTH AND DISEASE; Series Editor ; Ion Channels in Health and Disease; Copyright; Contents; List of Contributors; Preface; 1 -- The KCNE Family of Ion Channel Regulatory Subunits; INTRODUCTION; THE MECHANISTIC BASIS FOR FUNCTION OF KCNE PROTEINS; KCNE Regulation of KCNQ1 Channel Gating, Conductance, Ion Selectivity, and Pharmacology; ROLES OF KCNE SUBUNITS IN CARDIAC ION CURRENTS AND ARRHYTHMOGENESIS; KCNE1 in Human and Mouse Heart; KCNE2-5 in Human Heart; Consequences of Kcne Gene Knockout in Mice; CONCLUSIONS AND FUTURE QUESTIONS; References. | |
| 505 | 8 | |a 2 -- Ion Channel Trafficking INTRODUCTION; CARDIOMYOCYTE ORGANIZATION; Intercalated Discs; T-Tubules; Membrane Microdomains; TRAFFICKING IN HEALTHY AND DISEASED HEARTS; Ion Channel Forward Trafficking; Forward Trafficking: Normal Physiology; Maturation and Exiting Endoplasmic Reticulum; Sorting in the Trans-Golgi Network; Vesicular Traffic on the Cytoskeleton Highway; Insertion of Ion Channels Into the Sarcolemma; Introduction to Targeted Delivery; Targeted Delivery of Cx43 and Cav1.2 Channels; Membrane Anchors in Targeted Delivery; Cytoskeleton in Targeted Delivery. | |
| 505 | 8 | |a Accessory Proteins in Targeted DeliveryForward Trafficking: Pathophysiology; Channels Regulation Once in Membrane Subdomains; Membrane Subdomains: Normal Physiology; Intercalated Discs; T-Tubules; Membrane Subdomains: Pathophysiology; Channel Internalization; Internalization: Normal Physiology; Internalization: Pathophysiology; CONCLUSIONS; References; 3 -- Ryanodine Receptor Channelopathies in Skeletal and Cardiac Muscle; INTRODUCTION TO RYANODINE RECEPTORS; RYR1 MYOPATHIES. | |
| 505 | 8 | |a Acute or Evoked RyR1 Channelopathies: Malignant Hyperthermia, Enhanced Sensitivity to Heat, and Exercise-Induced RhabdomyolysisCongenital RYR1 Myopathies; RYR2-LINKED MYOPATHIES; Catecholaminergic Polymorphic Ventricular Tachycardia; Arrhythmogenic Right Ventricular Cardiomyopathy; SUMMARY/CONCLUSION; References; 4 -- Dravet Syndrome: A Sodium Channel Interneuronopathy; INTRODUCTION; VOLTAGE-GATED SODIUM CHANNELS; NAV1.1 CHANNELS AND INHERITED EPILEPSY; DRAVET SYNDROME; EPILEPSY AND PREMATURE DEATH IN DRAVET SYNDROME; COMORBIDITIES IN A MOUSE MODEL OF DRAVET SYNDROME. | |
| 505 | 8 | |a GENETIC AND PHARMACOLOGICAL TREATMENT OF DRAVET SYNDROMEGENETIC BACKGROUND EFFECTS IN DRAVET SYNDROME; GENETIC DISSECTION OF PHENOTYPES IN DRAVET SYNDROME; DRAVET SYNDROME AS A SODIUM CHANNEL INTERNEURONOPATHY; CONTRASTING VIEWS FROM STUDIES OF HUMAN-INDUCED PLURIPOTENT STEM CELLS; References; 5 -- Diagnosis, Treatment, and Mechanisms of Long QT Syndrome ; INTRODUCTION; DIAGNOSIS OF LONG QT SYNDROME; CLINICAL COURSE; GENES RESPONSIBLE FOR LONG QT SYNDROME (SEE TABLE 5.1); KCNQ1 (KV7.1, KVLQT1) (LQT1); KCNH2 (KV11.1, hERG) (LQT2); SCN5A (NaV1.5) (LQT3); ANK2 (LQT4); KCNE1 (LQT5); KCNE2 (LQT6). | |
| 650 | 0 | |a Ion channels. | |
| 650 | 2 | |a Ion Channels |0 (DNLM)D007473 | |
| 650 | 6 | |a Canaux ioniques. |0 (CaQQLa)201-0145111 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Anatomy & Physiology. |2 bisacsh | |
| 650 | 7 | |a Ion channels |2 fast |0 (OCoLC)fst00978573 | |
| 700 | 1 | |a Pitt, Geoffrey S., |e editor. | |
| 776 | 0 | 8 | |i Print version : |z 9780128020029 |
| 830 | 0 | |a Perspectives on translational cell biology series. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128020029 |z Texto completo |