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DNA repair in cancer therapy : molecular targets and clinical applications /
DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatm...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom :
Academic Press is an imprint of Elsevier,
2016.
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| Edición: | Second edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- 1. Overview of Current Targets and Clinical Trials: Bench to Clinic 2. MGMT a Critical DNA Repair Gene Target for Chemotherapy Resistance 3. Blockade of Base Excision Repair: Inhibition of Small Lesions Results in Big Consequences to Cancer Cells 4. PARP Inhibitors
- Scientific Rationale and Clinical Development for Cancer 5. Inhibiting Selective DNA Polymerases for Therapeutic Intervention 6. Targeting the Nucleotide Excision Repair Pathway for Therapeutic Applications 7. Homologous Recombination and ATM/ATR Targets 8. DNA Double Strand Break Repair by Nonhomologous End Joining and its Clinical Relevance 9. Mismatch repair 10. DNA Repair Signaling Targets 11. Personalized Cancer Medicine: DNA Repair Alterations is a Promising Predictive Marker in Cancer 12. The Role of DNA Damage and Repair in Neurotoxicity Caused by Cancer Therapies 13. Radiation DNA damage and use in cancer/therapeutics/dna repair 14. Fanconi Anemia- cross-link repair 15. Translesion DNA polymerases 16. BRCA1-BRCA2 pathway for HR and synthetic lethality 17. Synthetic lethality 18. Mechanisms of Resistance to Clinical PARP Inhibitors