Autophagy : cancer, other pathologies, inflammation, immunity, infection, and aging. Volume 9 /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Hayat, M. A., 1940- (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press is an imprint of Elsevier, [2016]
Temas:
Autophagic vacuoles.
Cell death.
Cellules > Mort.
SCIENCE > Life Sciences > Anatomy & Physiology.
Autophagic vacuoles
Cell death
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Autophagy
  • Copyright Page
  • Dedication
  • Mitophagy and Biogenesis
  • Autophagy and Cancer
  • Some Thoughts on Autophagy and Immunity
  • Autophagy: Friend or Foe?
  • Autophagy: If and When
  • What Happened When Autophagy Didn't
  • Sugar Isn't Always Sweet
  • Mitochondrial Mysteries
  • A Photo Is Static, An Instant in Time
  • Autophagy Subversion
  • Contents
  • Foreword by Roberta A. Gottlieb
  • Foreword by Eeva-Liisa Eskelinen
  • Preface
  • Contributors
  • Autophagy: Volume 1
  • Contributions
  • Autophagy: Volume 2
  • Contributions
  • Autophagy: Volume 3
  • Contributions
  • Autophagy: Volume 4
  • Contributions
  • Autophagy: Volume 5
  • Contributions
  • Autophagy: Volume 6
  • Contributions
  • Autophagy: Volume 7
  • Contributions
  • Autophagy: Volume 8
  • Contributions
  • I. MOLECULAR MECHANISMS
  • 1 Overview of Autophagy
  • Specific Functions of Autophagy (A Summary)
  • Autophagy in Normal Mammalian Cells
  • Endoplasmic Reticulum
  • Endoplasmic Reticulum Stress
  • Major Types of Autophagies
  • Macroautophagy (Autophagy)
  • Microautophagy
  • Chaperone-Mediated Autophagy
  • Autophagosome Formation
  • Autophagic Lysosome Reformation
  • Protein Synthesis
  • Methods
  • Abnormal Proteins
  • Molecular Chaperones
  • The Endoplasmic Reticulum
  • Endoplasmic Reticulum and Apoptosis
  • Autophagic Proteins
  • Protein Degradation Systems
  • Beclin-1
  • Nonautophagic Functions of Autophagy-Related Proteins
  • Microtubule-Associated Protein Light Chain 3
  • Aggrephagy
  • Aggresome, Ubiquitin Proteasome, and Autophagic Systems
  • Monitoring Autophagy
  • Reactive Oxygen Species (ROS)
  • Mammalian Target of Rapamycin (mTOR)
  • Role of Autophagy in Tumorigenesis and Cancer
  • Role of Autophagy in Immunity
  • Autophagy and Senescence
  • Role of Autophagy in Viral Defense and Replication
  • Role of Autophagy in Intracellular Bacterial Infection.
  • Role of Autophagy in Heart Disease
  • Role of Autophagy in Neurodegenerative Diseases
  • Cross-Talk Between Autophagy and Apoptosis
  • Autophagy and Ubiquitination
  • Autophagy and Necroptosis
  • Mitochondrial Fusion and Fission
  • Selective Autophagy
  • Allophagy
  • Axonophagy (Neuronal Autophagy)
  • Chromatophagy
  • Ciliophagy
  • Crinophagy
  • Exophagy
  • Glycophagy
  • Lipophagy
  • Lysophagy
  • Mitophagy
  • Nucleophagy
  • Pexophagy
  • Role of Pexophagy in Yeast
  • Reticulophagy
  • Ribophagy
  • Xenophagy
  • Zymophagy
  • References
  • 2 Autophagic Structures in Yeast
  • Introduction
  • Autophagic Bodies
  • Autophagosomes
  • Cvt Vesicles and Cvt Bodies
  • Pre-Autophagosomal Structure and Isolation Membranes
  • Pre-Autophagosomal Structure
  • PAS for Selective and Nonselective Autophagy
  • Isolation Membranes
  • Membrane Structures Involved in Pexophagy in P. pastoris
  • Atg9 Vesicles
  • Atg9 is an Integral Membrane Protein that Traffics through the Secretory Pathway
  • Atg9 Trafficking in Mutants of the Transport Protein Particle III Complex
  • Atg9 Trafficking in Mutants Defective in Golgi Functions
  • Atg9 Trafficking in Mutants Defective in Exocytic Secretion
  • PtdIns Phosphates in Atg9 Trafficking
  • Membrane Contact Sites Involved in Autophagy
  • Concluding Remarks
  • Acknowledgments
  • References
  • 3 Mitophagy: Sensors, Regulators, and Effectors
  • Introduction
  • PINK1-Parkin Mitophagy Pathway: A Partnership between Sensor and Regulator Proteins
  • Mitophagy Effectors
  • FUNDC1
  • NIX/BNIP3L
  • BNIP3
  • SMURF1
  • Conclusions
  • Acknowledgments
  • References
  • 4 Regulation of Autophagy by Actin-Associated Signaling Pathways
  • Introduction
  • Roles for Actin in Autophagy: Evidence From Yeast
  • ROCK Regulation of Autophagosome Formation
  • ROCK Regulation of Beclin 1 for Autophagy Induction
  • Activation of Beclin 1 at the Actin Cytoskeleton.
  • A Role for Myosin II During Early Stages of Autophagy
  • Role for Myosin VI During Late Stages of Autophagy Maturation
  • Role for Myosin VI During Early Autophagosome Formation
  • WASH Regulation of Endosome Trafficking
  • WASH Regulation of Ubiquitination
  • Convergence of WASH and Ambra1 Pathways
  • Conclusions
  • References
  • 5 G2019S Mutation of LRRK2 Increases Autophagy via MEK/ERK Pathway
  • Introduction
  • Role of Autophagy in Parkinson's Disease
  • Genetic and Environmental Factors in PD
  • Leucine-Rich Repeat Kinase 2 (LRRK2)
  • Protein Structure and Function of LRRK2
  • Pathogenic LRRK2 Mutations
  • LRRK2 G2019S
  • Role of LRRK2 in Autophagy
  • Autophagy Dysregulation in G2019S LRRK2
  • Susceptibility of G2019S LRRK2 Fibroblasts to MPP+
  • Acknowledgments
  • References
  • 6 Cargo Proteins Facilitate the Formation of Transport Vesicles, but not Autophagosomes
  • Introduction
  • Cargo Proteins of the Cvt Pathway
  • Receptors for the Cvt Pathway
  • Mechanism of APE1 Targeting to the PAS
  • Cargo-Dependent Organization of the PAS and Formation of Transport Vesicles
  • Regulation of the Cvt Vesicle Formation
  • Conclusions
  • Acknowledgments
  • References
  • 7 Absence of Bax and Bak: Implications for Autophagy and Alternative Mitochondrial Functions
  • Introduction
  • Mitochondria and Mitochondrial Pore Opening in Apoptosis
  • Function of Bax and Bak Proteins
  • Bax and Bak in Skeletal Muscle
  • Novel Mitochondrial Roles for Bax and Bak
  • Acknowledgments
  • References
  • 8 The Antiapoptotic Protein BCL-2 Has Also an Antiautophagy Role Through Beclin 1 Inhibition
  • Discovery of the Beclin 1-BCL-2 Interaction
  • Role and Regulation of the Beclin-1-BCL-2 Interaction in Autophagosome Formation
  • Regulation of the Beclin 1-BCL-2 Interaction by Extracellular Cues and Subsequent Posttranslational Modifications.
  • Role of BCL-2 Intracellular Localization
  • The Beclin 1-BCL-2 Interaction Is Affected by Their Many Partners
  • Role of the Beclin-1-BCL-2 Interaction in Physiopathology
  • Cell Death
  • Exercise
  • Immunity/Virology
  • Neurodegeneration
  • Cancer
  • Conclusion
  • Acknowledgments
  • References
  • 9 Organic Pollutant Perfluorooctane Sulfonate-Induced Lysosomal Membrane Permeabilization Blocks Autophagy Flux in Human He ...
  • Introduction
  • PFOS Blocked Autophagosome Degradation in HepG2 Cells
  • PFOS Caused Autophagosome Accumulation in HepG2 Cells
  • PFOS Increased the Expression of LC3-II and P62 in HepG2 Cells
  • Chloroquine Did Not Further Increased the Expression of LC3-II in LC3 Turnover Assay
  • PFOS Induced LMP in HepG2 Cells
  • PFOS Caused Autophagic Cell Death in HepG2 Cells
  • Discussion
  • Acknowledgments
  • References
  • II. AUTOPHAGY AND CANCER
  • 10 Mutant p53 Located in the Cytoplasm Inhibits Autophagy
  • Introduction
  • Overview of the Autophagic Pathway
  • Mechanisms of Autophagy Regulation
  • Autophagy and Cancer Development
  • The Tumor Suppressor p53
  • p53 and Autophagy
  • Nuclear p53 and Autophagy Regulation
  • Cytoplasmic p53 and Autophagy Regulation
  • Conclusion
  • Acknowledgments
  • References
  • 11 Role of Autophagy in Regulation Survival or Death of Cancer Cells
  • Introduction
  • Common Oncogenic Signals of Autophagy
  • TP53
  • Death-Associated Protein Kinase Family
  • ARF Isoforms
  • PI3K/Akt/mTOR Pathway
  • Stress Mediators: ROS, Ca2+, Mitochondrial, and ER Stress
  • Autophagy Regulates Survival of Cancer Cells
  • Activation of Autophagy in the Regulation of Cancer Cell Survival
  • Inhibition of Autophagy in Regulation of Cancer Cell Survival
  • Autophagic Cell Death in Cancer Cells
  • Autophagy Regulates Cancer Development
  • Anticancer Therapeutic Application of Autophagy
  • Discussion
  • References.
  • 12 Regulation of Autophagy in Chronic Lymphocytic Leukemia: The Role of Histone Deacetylase Inhibitors
  • Introduction
  • Chronic Lymphocytic Leukemia: An Overview
  • Autophagy at a Glance
  • Basal Autophagy in CLL
  • The Role of PI3K/AKT/mTOR Pathway
  • The Role of CXCL12/CXCR4 Signaling
  • The Role of the Antiapoptotic BCL-2 Family Proteins
  • The Role of p53
  • The Role of microRNAs
  • Evidence for Basal Autophagy as an Active Pro-Survival Process
  • Pharmacological Modulation of Autophagy in CLL
  • Activation of Autophagy as a Pro-Survival Mechanism in Primary CLL Cells
  • Activation of Autophagy as a Pro-Death Mechanism in Primary CLL Cells
  • Overview of HDAC Inhibitors and Their Anticancer Effects
  • Histone Acetylation and Deacetylation in Cancer
  • Classification of HDACs
  • Classification of HDAC Inhibitors
  • HDAC Inhibitors in Clinic and Clinical Trials for Anticancer Therapy
  • Anticancer Activity of HDAC Inhibitors
  • HDAC Inhibitors and Autophagy
  • Mechanisms of HDAC Inhibitor-Mediated Autophagy
  • The Pro-Death and Pro-Survival Effects of HDAC Inhibitor-Elicited Autophagy
  • HDAC Inhibitors as Autophagy Suppressors
  • Conclusions and Perspectives
  • References
  • 13 Improving the Survival of Mesenchymal Stromal Cells Against Oxidative Stress in Transplantation: Role of Autophag ...
  • Introduction
  • Autophagy
  • Mesenchymal Stromal Cells
  • Stem Cell and Autophagy
  • Role of Autophagy Induction in MSCs Under Oxidative Stress
  • Dynamic Autophagic Flux in BMSCs Under Oxidative Stress
  • Prolonged Oxidative Exposure Enhances Apoptosis in BMSCs
  • Autophagy Manipulation Regulates the Cell Survival of BMSCs
  • Discussion
  • Conclusions
  • Acknowledgments
  • References
  • III. AUTOPHAGY AND INFECTION
  • 14 Low-Density Lipoprotein Receptor-Related Protein-1 Mediates Vacuolating Cytotoxin-Induced Autophagy and Apoptosi ...
  • Introduction.

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