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Developing therapeutics for Alzheimer's disease : progress and challenges /
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press is an imprint of Elsevier,
2016.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- 1. The Complex Pathways to Mechanism-Based Therapeutics in Alzheimer's Disease; 2. The Genetic Basis of Alzheimer's Disease; 3. B-Secretase Inhibition; 4. Y-Secretase Inhibitors: from Chemical Probes to Drug Development; 5. Therapeutic Targeting of AB42; 6. Modulators of Amyloid B-Protein (AB) Self-Assembly; 7. Anti-Amyloid-B Immunotherapy for Alzheimer's Disease; 8. Targeting AB Receptors to Modify Alzheimer's Disease Progression; 9. Blood-Brain Barrier Transport of Alzheimer's Amyloid B-Peptide; 10. Alzheimer's Disease Therapeutics Targeting Apolipoprotein E; 11. Microtubule Stabilization; 12. Tau Phosphorylation as a Therapeutic Target in Alzheimer's Disease; 13. Stimulation of Tau Degradation; 14. Passive Immunotherapy for Tau Pathology; 15. Inhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer's Disease; 16. Neuroprotective Strategies for Alzheimer's Disease Prevention and Therapy; 17. Symptomatic Cognitive Enhancing Agents; 18. Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria; 19. Preclinical and Clinical Issues in Alzheimer Drug Development; 20. Molecular Imaging in Alzheimer Clinical Trials; 21. Fluid Biomarkers and Diagnostics; 22. Non-Pharmacologic Activity Interventions to Prevent Alzheimer's Disease; 23. Prospects and Challenges for Alzheimer Therapeutics