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Big on BK : current insights into the function of large conductance voltage- and Ca2+- activated K+ channels at the molecular, cellular and systemic levels /
Big on Bk: Current Insights into the Function of Large Conductance Voltage- and Ca2+- Activated K+ Channels at the Molecular, Cellular and Systemic Levels, a volume in the International Review of Neurobiology series, is a comprehensive overview of the state-of-the-art research into this area. It rev...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press is an imprint of Elsevier,
2016.
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| Colección: | International review of neurobiology ;
v. 128. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- 3. Structural Characteristics; 4. Modulation of the BK Channel's Biophysical Properties by [beta] Subunits; 5. Modulation of the BK Channel's Biophysical Properties by [gamma] Subunits; 6. Modulation of the BK Channel's Pharmacological Properties by [beta] and [gamma] Subunits; 7. Stoichiometry; 8. Physiological and Pathological Relevance or Roles; 9. Perspectives; Acknowledgment; References; Chapter Three: Posttranscriptional and Posttranslational Regulation of BK Channels; 1. Introduction; 1.1. Spatiotemporal Control of BK Channel Number and Activity; 2. Posttranscriptional Regulation.
- 2.1. Alternative Pre-mRNA Splicing2.1.1. Control of Alternative Splicing of the Pore-Forming [alpha]-Subunit; 2.1.2. Alternative Splicing Controls the Biophysical Properties of BK Channels and Their Regulation by PTMs, Accessory Su ... ; 2.1.3. Splicing and Control of BK Channel Trafficking; 2.1.4. Splicing and the Control of Regulatory [beta]-Subunits; 2.2. miRNA Control of Abundance and Diversity; 2.3. RNA Editing; 3. Posttranslational Modification; 3.1. Reversible Protein Phosphorylation; 3.1.1. Regulation by Reversible Serine-Threonine Protein Phosphorylation.
- 3.1.1.1. Control of Channel Activity via Regulation of Pore-Forming [alpha]-Subunits3.1.1.2. Control of Regulatory Subunits by Serine/Threonine Phosphorylation; 3.1.1.3. Control of Channel Trafficking; 3.1.1.4. Protein Serine/Threonine Dephosphorylation; 3.1.2. Reversible Tyrosine Phosphorylation; 3.2. Lipidation; 3.2.1. Reversible S-Acylation; 3.2.2. Atypical Internal Protein Myristoylation; 3.3. N-Linked Glycosylation; 3.4. Ubiquitination; 4. Conclusions and Perspectives; Acknowledgments; References; Chapter Four: Protein Network Interacting with BK Channels; 1. Introduction.
- Front Cover; Big on BK: Current Insights into the Function of Large Conductance Voltage- and Ca2+-Activated K+ Channels at the Molecular ... ; Copyright; Contents; Contributors; Preface; Chapter One: Biophysics of BK Channel Gating; 1. Introduction; 2. Voltage-Dependent Gating in BK Channels; 2.1. Our Current Understanding of Voltage-Dependent Channel Gating; 2.2. Operation of the Noncanonical BK Channel VSD; 2.3. Modulation of BK Voltage-Dependent Gating; 3. Ligand-Dependent Gating in BK Channels; 3.1. Ca2+-Dependent Gating; 3.2. Mg2+-Dependent Gating; 4. The BK Allosteric Gating Mechanism.
- 4.1. The HCA and HA Models of Allosteric BK Channel Activation4.2. Electromechanical Coupling; 4.3. Modulation of Electromechanical Coupling; 4.4. Coupling Between the Ca2+ Sensors and the Gate; 4.5. Modulation of BK Ca2+ Sensitivity; 4.6. Coupling Between Voltage and Ca2+ Sensors; 4.7. Coupling Between RCK1 and RCK2 Ca2+ Sensors; 5. The Extraordinary Conductance of BK Channels; 6. Concluding Remarks: The BK Channel as a Rebel and a Model; Acknowledgments; References; Chapter Two: Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits; 1. Introduction; 2. Discovery.