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160525s2016 enk ob 001 0 eng d |
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|a 616/.042
|2 23
|
| 245 |
0 |
0 |
|a Thresholds of genotoxic carcinogens :
|b from mechanisms to regulation /
|c edited by Takehiko Nohmi, Shoji Fukushima.
|
| 264 |
|
1 |
|a London, UK :
|b Academic Press is an imprint of Elsevier,
|c 2016.
|
| 300 |
|
|
|a 1 online resource
|
| 336 |
|
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|a text
|b txt
|2 rdacontent
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| 337 |
|
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|a computer
|b c
|2 rdamedia
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| 338 |
|
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|a online resource
|b cr
|2 rdacarrier
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| 500 |
|
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|a Includes index.
|
| 588 |
0 |
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|a Online resource; title from PDF title page (ScienceDirect, viewed June 6, 2016).
|
| 505 |
0 |
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|a Title page; Table of Contents; Copyright; List of Contributors; Preface; Chapter 1. Qualitative and Quantitative Assessments on Low-Dose Carcinogenicity of Genotoxic Hepatocarcinogens: Dose-Response for Key Events in Rat Hepatocarcinogenesis; Abstract; Introduction; Qualitative and Quantitative Analyses on Low-Dose Carcinogenicity of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the Rat Liver; Qualitative and Quantitative Analyses on Low-Dose Hepatocarcinogenicity of 2-Amino-3-methylimidazo[4,5-f]quinoline in the Rat Liver.
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| 505 |
8 |
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|a Qualitative and Quantitative Analysis on Low-Dose Hepatocarcinogenicity of N-nitrosodiethylamine in the Rat LiverDiscussion; References; Chapter 2. Thresholds for Hepatocarcinogenicity of DNA-Reactive Compounds; Abstract; Introduction; Dose-Effect Studies of Initiation of Liver Carcinogenesis; Conclusions; Relevance to Humans; References; Chapter 3. Interaction of Low-Dose Radiation and Chemicals in Cancer Risk; Abstract; Epidemiological Analysis of Cancer Risk; Interaction of Radiation and Other Carcinogens; Data From Animal Experiments; Conclusion; Acknowledgments; References.
|
| 505 |
8 |
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|a Chapter 4. Possible Mechanisms Underlying Genotoxic Thresholds: DNA Repair and Translesion DNA SynthesisAbstract; Introduction; Challenges in Identification of Genotoxicity of Chemicals; Possible Mechanisms Underlying Genotoxic Thresholds; Significance of DNA Repair Mechanisms in the Suppression of Mutagenesis and Tumorigenesis in Mammals; TLS as a Critical Factor for Mutagenesis; Future Perspectives; Acknowledgments; References; Chapter 5. DNA Repair and Its Influence on Points of Departure for Alkylating Agent Genotoxicity; Abstract; Introduction.
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| 505 |
8 |
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|a The Paradigm Shift in Response to Low Doses of Alkylating AgentsAlkylating Agent Mechanism of Action; DNA Repair of Alkyl Adducts: Potential Influences on PoDs; Mechanistic Evidence Supporting a PoD for EMS; Mechanistic Evidence Supporting a PoD for ENU; Mechanistic Evidence Supporting a PoD for MMS; Mechanistic Evidence Supporting a PoD for MNU; Concluding Remarks; References; Chapter 6. The Role of Endogenous Versus Exogenous DNA Damage in Risk Assessment; Abstract; Introduction; Aldehydes; Alkylating Agents; Oxidative Stress; Ionizing Radiation.
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| 505 |
8 |
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|a Quantifying Complex Dose-Response Relationships to Support Risk AssessmentsConclusion; References; Chapter 7. Thresholds of Toxicological Concern for Genotoxic Impurities in Pharmaceuticals; Abstract; Introduction; Genotoxic and Nongenotoxic Carcinogens; Thresholds of Chemical Genotoxicity; Risk Management for Genotoxic Carcinogens; Risk Assessment and Control of Genotoxic Impurities in Pharmaceuticals; Conclusion; References; Chapter 8. Practical Thresholds in the Derivation of Occupational Exposure Limits (OELs) for Carcinogens; Abstract; Introduction.
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| 504 |
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|a Includes bibliographical references at the end of each chapters and index.
|
| 650 |
|
0 |
|a Genetic toxicology.
|
| 650 |
|
0 |
|a Carcinogenesis.
|
| 650 |
|
0 |
|a DNA damage.
|
| 650 |
|
0 |
|a Drugs
|x Dose-response relationship.
|
| 650 |
|
0 |
|a Mutagenicity testing.
|
| 650 |
1 |
2 |
|a Carcinogenesis
|0 (DNLM)D063646
|
| 650 |
2 |
2 |
|a Carcinogens
|x toxicity
|0 (DNLM)D002273Q000633
|
| 650 |
2 |
2 |
|a DNA Damage
|0 (DNLM)D004249
|
| 650 |
2 |
2 |
|a Dose-Response Relationship, Drug
|0 (DNLM)D004305
|
| 650 |
2 |
2 |
|a Mutagenicity Tests
|0 (DNLM)D009152
|
| 650 |
|
6 |
|a Toxicologie g�en�etique.
|0 (CaQQLa)201-0004973
|
| 650 |
|
6 |
|a Canc�erogen�ese.
|0 (CaQQLa)201-0004972
|
| 650 |
|
6 |
|a ADN
|x L�esions.
|0 (CaQQLa)201-0195055
|
| 650 |
|
6 |
|a M�edicaments
|x Relations dose-effet.
|0 (CaQQLa)201-0023148
|
| 650 |
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6 |
|a Mutag�enicit�e.
|0 (CaQQLa)201-0244933
|
| 650 |
|
7 |
|a HEALTH & FITNESS
|x Diseases
|x General.
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL
|x Clinical Medicine.
|2 bisacsh
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| 650 |
|
7 |
|a MEDICAL
|x Diseases.
|2 bisacsh
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| 650 |
|
7 |
|a MEDICAL
|x Evidence-Based Medicine.
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL
|x Internal Medicine.
|2 bisacsh
|
| 650 |
|
7 |
|a Mutagenicity testing
|2 fast
|0 (OCoLC)fst01031140
|
| 650 |
|
7 |
|a Drugs
|x Dose-response relationship
|2 fast
|0 (OCoLC)fst00898805
|
| 650 |
|
7 |
|a DNA damage
|2 fast
|0 (OCoLC)fst00886581
|
| 650 |
|
7 |
|a Carcinogenesis
|2 fast
|0 (OCoLC)fst00846974
|
| 650 |
|
7 |
|a Genetic toxicology
|2 fast
|0 (OCoLC)fst00940097
|
| 700 |
1 |
|
|a Nohmi, Takehiko,
|e editor.
|
| 700 |
1 |
|
|a Fukushima, Shoji,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|a Nohmi, Takehiko.
|t Thresholds of Genotoxic Carcinogens : From Mechanisms to Regulation.
|d : Elsevier Science, �2016
|z 9780128016633
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128016633
|z Texto completo
|
