Cargando…
Klotho /
Klotho is the latest edition of a series first published in 1943 on Vitamins and Hormones and the longest-running serial published by Academic Press. It provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic, with volumes focusing on a sing...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press is an imprint of Elsevier,
2016.
|
| Edición: | First edition. |
| Colección: | Vitamins and hormones ;
v. 101. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- 1. Introduction2. The Components of the Signaling Complex; 2.1. Klotho-Beta; 2.1.1. The Klotho Family of Receptors; 2.1.2. KLB Structure; 2.1.3. KLB Tissue Expression; 2.2. Fibroblast Growth Factor Receptors; 2.2.1. The Fibroblast Growth Factor Receptor Family; 2.2.2. Fibroblast Growth Factor Receptor Structure; 2.2.3. FGFR1c Tissue Expression; 2.3. Endocrine FGF21; 2.3.1. The Fibroblast Growth Factor Family; 2.3.2. FGF Structure; 2.3.3. Endocrine FGF21 Structure; 2.3.4. Endocrine FGF21 Tissue Expression; 3. Specific Interactions Driving Complex Formation; 3.1. Interaction of FGF21 and KLB.
- 3.2. Interaction of FGF21 and FGFR13.3. Interaction of KLB and FGFR1; 3.4. KLB Domains Relevant for Binding; 4. Stoichiometry of the Signaling Complex; 4.1. Preformed KLB Heterodimers with FGFR1c/4; 5. Other Regulators of the Signaling Complex Formation; 5.1. KLB Inactivation by the Galectin Lattice; 5.2. ECM Regulation of FGFRs; 5.3. Fibroblast Growth Factor Receptor 5; 6. Summary; References; Chapter Three: Klotho-Dependent Cellular Transport Regulation; 1. Introduction; 1.1. Gene Structure and Klotho Protein Types; 1.2. Ectodomain Shedding and Some Functions Mediated by Klotho.
- 1.3. Transport Proteins in the Different Types of Plasma Membrane Transport Systems2. Klotho in the Regulation of Cellular Transport; 2.1. Klotho in the Regulation of Ion Channels; 2.2. Klotho in the Regulation of Carriers; 2.3. Klotho in the Regulation of Na+/K+-ATPase; 3. Conclusion and Future Directions; Acknowledgment; References; Chapter Four: Klotho and the Growth Hormone/Insulin-Like Growth Factor 1 Axis: Novel Insights into Complex Interactions; 1. The Pituitary Gland and the GH/IGF-1 Axis; 1.1. Regulation of GH Transcription and Secretion.
- 1.1.1. Hypothalamic Regulation of GH Secretion1.1.2. Peripheral Regulation of GH Secretion; 1.1.3. Autocrine and Paracrine Regulation of GH Secretion; 1.2. The Activities of GH and IGF-1; 2. Klotho: History, Structure, Functions; 3. Klotho as a Circulating Hormone; 3.1. Available Tests; 3.2. Factor Affecting Circulating Klotho Levels; 3.3. Regulation of Klotho Shedding; 4. Klotho and the Pituitary: Lessons from Mice and Humans; 5. Klotho Regulates GH Secretion; 5.1. Mechanisms of Klotho Activity on GH Secretion; 6. Klotho and the GH/IGF-1 Axis in Humans: Health and Disease States.