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Intracellular consequences of amyloid in Alzheimer's disease /
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Academic Press,
2016.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Intracellular Consequences of Amyloid in Alzheimer's Disease; Copyright Page; Dedication; Contents; About the Cover; About the Author; Preface; Acknowledgments; Introduction; References; 1 Amyloid Basis of Alzheimer's Disease; Historical Background of Amyloid and Plaques; Amyloid Generation and Processing; A? States; Detecting Intraneuronal Amyloid; APP/A?-Related Antibodies; Fixation and Pretreatment Factors; Summary; References; 2 Origin(s) of Intraneuronal Amyloid; A? From Within the Neuron; A? From Outside the Neuron; A? From Within the Brain; A? From Outside the Brain.
- Plasma A?Platelets; Epithelial Cells; The Blood-Brain Barrier; Entry of Extracellular A? Into the Neurons;?7 Receptors; Integrins and NMDA Receptors; Receptor for Advanced Glycosylation End Products; Apolipoprotein E; Summary; References; 3 Natural Intracellular Consequences of Amyloid; A? Functions in Normal Neurons; Neuronal Development; Viability; Arborization; Synaptic Physiology; Learning and Memory; BACE1-/- Mice; A? Functions in Other Cell Types; Fat Metabolism; Mitogenic, Cell Growth, and Migration Activity; Antimicrobial Activity; Intracellular Cargo Receptor; Wound Healing; Summary.
- On Calcium SignalingOn Apoptosis; Morphological and Accumulating Levels Over Time; Summary; References; 5 Intraneuronal Amyloid and Plaque Formation; Models of Plaque Formation; Deposition-Based Models; Random Deposition Into the Parenchyma; Synaptic Deposition; Lytic Model; Intraneuronal A? Then Plaques; Characterizing Plaque Types: Does It Matter?; Relationship of Intraneuronal A?, Plaques, and Neurofibrillary Tangles; Summary; References; 6 Intraneuronal Amyloid and Cognitive Impairment; Intraneuronal A? to Cognition; Intracellular Levels.
- Correlation of A?-Induced Synaptic Changes With CognitionSummary; References; 7 Intraneuronal Amyloid and Inflammation; Efficacy of NSAIDs; Intraneuronal A?'s Role in Gliosis; Inflammatory Cells Exacerbate AD; Reactive Microglia; Activated Astrocytes; Summary; References; 8 Consequences of Intracellular Amyloid in Vascular System; AD as a Vascular Disease; Risk Factors; Cerebral Amyloid Angiopathy; Vascular Dementia; Type 2 Diabetes; Source of the Vascular-Ladened A?; Brain-Derived A?; Peripherally Derived A?; Locally Derived A?; Pathological Aspects of the BBB.